Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia
Purpose. To investigate the correlation between aqueous and serum levels of pigment epithelium-derived factor (PEDF) and macular choroidal thickness in high myopia patients, both with and without choroidal neovascularization (CNV). Methods. Serum and aqueous levels of PEDF were measured by enzyme-li...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/731461 |
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| author | Wei Chen Yubo Guan Guanghui He Zhiwei Li Hui Song Shiyong Xie Quanhong Han |
| author_facet | Wei Chen Yubo Guan Guanghui He Zhiwei Li Hui Song Shiyong Xie Quanhong Han |
| author_sort | Wei Chen |
| collection | DOAJ |
| description | Purpose. To investigate the correlation between aqueous and serum levels of pigment epithelium-derived factor (PEDF) and macular choroidal thickness in high myopia patients, both with and without choroidal neovascularization (CNV). Methods. Serum and aqueous levels of PEDF were measured by enzyme-linked immunosorbent assay in 36 high myopia patients (36 eyes) with no CNV (non-CNV group), 14 high myopia patients (14 eyes) with CNV (CNV group), and 42 nonmyopia patients (42 eyes) (control group). Macular choroidal thickness was measured by enhanced-depth imaging optical coherence tomography. Results. Aqueous levels of PEDF were significantly higher in CNV group compared with non-CNV (P<0.001) and control (P<0.001) groups. Macular choroidal thicknesses were significantly decreased in the non-CNV and CNV groups compared with the control (P<0.001) group. A statistically significant difference (P=0.012) was found between the CNV and non-CNV groups. There was a positive correlation between aqueous PEDF and macular choroidal thickness in the non-CNV group (P=0.005), but no correlation with the CNV group. No correlation between serum PEDF and macular choroidal thickness was detected in the three groups. Conclusion. Variations in aqueous PEDF levels coincide with changes in macular choroidal thickness in high myopia patients with no CNV, while no such relationship exists in high myopia patients with CNV. |
| format | Article |
| id | doaj-art-2897be4fc3ef4b12bffa04c64bb584cc |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Journal of Ophthalmology |
| spelling | doaj-art-2897be4fc3ef4b12bffa04c64bb584cc2025-02-03T01:23:54ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/731461731461Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High MyopiaWei Chen0Yubo Guan1Guanghui He2Zhiwei Li3Hui Song4Shiyong Xie5Quanhong Han6Clinical College of Ophthalmology, Tianjin Medical University, No. 4, Gansu Road, Tianjin 300020, ChinaClinical College of Ophthalmology, Tianjin Medical University, No. 4, Gansu Road, Tianjin 300020, ChinaClinical College of Ophthalmology, Tianjin Medical University, No. 4, Gansu Road, Tianjin 300020, ChinaDepartment of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, ChinaClinical College of Ophthalmology, Tianjin Medical University, No. 4, Gansu Road, Tianjin 300020, ChinaClinical College of Ophthalmology, Tianjin Medical University, No. 4, Gansu Road, Tianjin 300020, ChinaClinical College of Ophthalmology, Tianjin Medical University, No. 4, Gansu Road, Tianjin 300020, ChinaPurpose. To investigate the correlation between aqueous and serum levels of pigment epithelium-derived factor (PEDF) and macular choroidal thickness in high myopia patients, both with and without choroidal neovascularization (CNV). Methods. Serum and aqueous levels of PEDF were measured by enzyme-linked immunosorbent assay in 36 high myopia patients (36 eyes) with no CNV (non-CNV group), 14 high myopia patients (14 eyes) with CNV (CNV group), and 42 nonmyopia patients (42 eyes) (control group). Macular choroidal thickness was measured by enhanced-depth imaging optical coherence tomography. Results. Aqueous levels of PEDF were significantly higher in CNV group compared with non-CNV (P<0.001) and control (P<0.001) groups. Macular choroidal thicknesses were significantly decreased in the non-CNV and CNV groups compared with the control (P<0.001) group. A statistically significant difference (P=0.012) was found between the CNV and non-CNV groups. There was a positive correlation between aqueous PEDF and macular choroidal thickness in the non-CNV group (P=0.005), but no correlation with the CNV group. No correlation between serum PEDF and macular choroidal thickness was detected in the three groups. Conclusion. Variations in aqueous PEDF levels coincide with changes in macular choroidal thickness in high myopia patients with no CNV, while no such relationship exists in high myopia patients with CNV.http://dx.doi.org/10.1155/2015/731461 |
| spellingShingle | Wei Chen Yubo Guan Guanghui He Zhiwei Li Hui Song Shiyong Xie Quanhong Han Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia Journal of Ophthalmology |
| title | Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia |
| title_full | Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia |
| title_fullStr | Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia |
| title_full_unstemmed | Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia |
| title_short | Aqueous Levels of Pigment Epithelium-Derived Factor and Macular Choroidal Thickness in High Myopia |
| title_sort | aqueous levels of pigment epithelium derived factor and macular choroidal thickness in high myopia |
| url | http://dx.doi.org/10.1155/2015/731461 |
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