Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders
Inflammasomes are multiprotein complexes that trigger the activation of caspases-1 and subsequently the maturation of proinflammatory cytokines interleukin-1β and interleukin-18. These cytokines play a critical role in mediating inflammation and innate immunity response. Among various inflammasome c...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/9238290 |
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| _version_ | 1832556871496499200 |
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| author | Keren Zhou Ligen Shi Yan Wang Sheng Chen Jianmin Zhang |
| author_facet | Keren Zhou Ligen Shi Yan Wang Sheng Chen Jianmin Zhang |
| author_sort | Keren Zhou |
| collection | DOAJ |
| description | Inflammasomes are multiprotein complexes that trigger the activation of caspases-1 and subsequently the maturation of proinflammatory cytokines interleukin-1β and interleukin-18. These cytokines play a critical role in mediating inflammation and innate immunity response. Among various inflammasome complexes, the NLRP3 inflammasome is the best characterized, which has been demonstrated as a crucial role in various diseases. Here, we review recently described mechanisms that are involved in the activation and regulation of NLRP3 inflammasome. In addition, we summarize the recent researches on the role of NLRP3 inflammasome in central nervous system (CNS) diseases, including traumatic brain injury, ischemic stroke and hemorrhagic stroke, brain tumor, neurodegenerative diseases, and other CNS diseases. In conclusion, the NLRP3 inflammasome may be a promising therapeutic target for these CNS diseases. |
| format | Article |
| id | doaj-art-28951161aa044ea98a6685ae5d67b14d |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-28951161aa044ea98a6685ae5d67b14d2025-02-03T05:44:13ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/92382909238290Recent Advances of the NLRP3 Inflammasome in Central Nervous System DisordersKeren Zhou0Ligen Shi1Yan Wang2Sheng Chen3Jianmin Zhang4Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaInflammasomes are multiprotein complexes that trigger the activation of caspases-1 and subsequently the maturation of proinflammatory cytokines interleukin-1β and interleukin-18. These cytokines play a critical role in mediating inflammation and innate immunity response. Among various inflammasome complexes, the NLRP3 inflammasome is the best characterized, which has been demonstrated as a crucial role in various diseases. Here, we review recently described mechanisms that are involved in the activation and regulation of NLRP3 inflammasome. In addition, we summarize the recent researches on the role of NLRP3 inflammasome in central nervous system (CNS) diseases, including traumatic brain injury, ischemic stroke and hemorrhagic stroke, brain tumor, neurodegenerative diseases, and other CNS diseases. In conclusion, the NLRP3 inflammasome may be a promising therapeutic target for these CNS diseases.http://dx.doi.org/10.1155/2016/9238290 |
| spellingShingle | Keren Zhou Ligen Shi Yan Wang Sheng Chen Jianmin Zhang Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders Journal of Immunology Research |
| title | Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders |
| title_full | Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders |
| title_fullStr | Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders |
| title_full_unstemmed | Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders |
| title_short | Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders |
| title_sort | recent advances of the nlrp3 inflammasome in central nervous system disorders |
| url | http://dx.doi.org/10.1155/2016/9238290 |
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