Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study
Abstract Background Immune cells play a crucial role in the progression of thyroid cancer. However, previous research on the link between immune cells and thyroid cancer has produced conflicting results. Methods Based on the public available genome-wide association studies summary statistics, we per...
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| Format: | Article |
| Language: | English |
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Springer
2025-04-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02249-0 |
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| author | Shurong Wang Zhouyu Fang Wenjin Xiao Ying Xie Yueyue Zhang Zhihua Liu |
| author_facet | Shurong Wang Zhouyu Fang Wenjin Xiao Ying Xie Yueyue Zhang Zhihua Liu |
| author_sort | Shurong Wang |
| collection | DOAJ |
| description | Abstract Background Immune cells play a crucial role in the progression of thyroid cancer. However, previous research on the link between immune cells and thyroid cancer has produced conflicting results. Methods Based on the public available genome-wide association studies summary statistics, we performed a two-sample Mendelian randomization (MR) to evaluate the causal association between 731 immune phenotypes (including median fluorescence intensities, absolute cell counts, relative cell counts, and morphological parameters) and thyroid cancer. The inverse variance weighting method was employed to investigate the causal relationship between exposure and outcome. Moreover, multiple sensitivity analyses, such as MR-Egger, weighted median, and MR-PRESSO, were simultaneously applied to reinforce the final results. Results After false discovery rate correction, four immunophenotypes were found to be significantly associated with a decreased risk of thyroid cancer. And six immunophenotypes were significantly associated with an increased risk of thyroid cancer. Conclusions Our study has demonstrated the close connection between immune cells and thyroid cancer by genetic means, thus providing guidance for future clinical research. |
| format | Article |
| id | doaj-art-2890e2ca1f2f4053a31f04c1f9ac8a74 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-2890e2ca1f2f4053a31f04c1f9ac8a742025-08-20T02:11:47ZengSpringerDiscover Oncology2730-60112025-04-011611910.1007/s12672-025-02249-0Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization studyShurong Wang0Zhouyu Fang1Wenjin Xiao2Ying Xie3Yueyue Zhang4Zhihua Liu5Department of Endocrinology, The Second Affiliated Hospital of Soochow UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Soochow UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Soochow UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Soochow UniversityDepartment of Medical Imaging, The Second Affiliated Hospital of Soochow UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Soochow UniversityAbstract Background Immune cells play a crucial role in the progression of thyroid cancer. However, previous research on the link between immune cells and thyroid cancer has produced conflicting results. Methods Based on the public available genome-wide association studies summary statistics, we performed a two-sample Mendelian randomization (MR) to evaluate the causal association between 731 immune phenotypes (including median fluorescence intensities, absolute cell counts, relative cell counts, and morphological parameters) and thyroid cancer. The inverse variance weighting method was employed to investigate the causal relationship between exposure and outcome. Moreover, multiple sensitivity analyses, such as MR-Egger, weighted median, and MR-PRESSO, were simultaneously applied to reinforce the final results. Results After false discovery rate correction, four immunophenotypes were found to be significantly associated with a decreased risk of thyroid cancer. And six immunophenotypes were significantly associated with an increased risk of thyroid cancer. Conclusions Our study has demonstrated the close connection between immune cells and thyroid cancer by genetic means, thus providing guidance for future clinical research.https://doi.org/10.1007/s12672-025-02249-0Thyroid cancerImmune cellsCausal associationGWASMendelian randomization |
| spellingShingle | Shurong Wang Zhouyu Fang Wenjin Xiao Ying Xie Yueyue Zhang Zhihua Liu Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study Discover Oncology Thyroid cancer Immune cells Causal association GWAS Mendelian randomization |
| title | Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study |
| title_full | Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study |
| title_fullStr | Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study |
| title_full_unstemmed | Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study |
| title_short | Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study |
| title_sort | causal role of immune cells in thyroid cancer a two sample mendelian randomization study |
| topic | Thyroid cancer Immune cells Causal association GWAS Mendelian randomization |
| url | https://doi.org/10.1007/s12672-025-02249-0 |
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