Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy
The cellular uptake and tissue dispersion efficiency of nanomedicines are crucial for realizing their biological functionality. As a cutting-edge category of nanomedicine, covalent organic frameworks (COFs)-based photosensitizers, have been extensively employed in cancer phototherapy in recent years...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-05-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25000180 |
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| author | Qi-Chao Yang Yuan-Yuan Wang Shuo Wang An Song Wen-Da Wang Liang Zhang Zhi-Jun Sun |
| author_facet | Qi-Chao Yang Yuan-Yuan Wang Shuo Wang An Song Wen-Da Wang Liang Zhang Zhi-Jun Sun |
| author_sort | Qi-Chao Yang |
| collection | DOAJ |
| description | The cellular uptake and tissue dispersion efficiency of nanomedicines are crucial for realizing their biological functionality. As a cutting-edge category of nanomedicine, covalent organic frameworks (COFs)-based photosensitizers, have been extensively employed in cancer phototherapy in recent years. However, the inherent aggregation tendency of COFs hinders their uptake by tumor cells and dispersion within tumor tissues, thereby limiting their therapeutic efficacy. In this study, we employed Fusobacterium nucleatum (F.n.), a prevalent intratumoral bacterium, to construct a bacterium membrane-wrapped COF, COF-306@FM, which is readily taken up by cancer cells and uniformly dispersed within tumor tissues. Meanwhile, the F.n. membrane can also serve as an immune adjuvant to warm up the “cold” tumor immune microenvironment by enhancing the CD8+ T and B cells infiltration, and inducing the formation of tumor-located tertiary lymphoid structures. Consequently, the response rate of αPD-L1 immunotherapy was drastically promoted to efficiently prevent tumor metastasis and recurrence, causing 84.6 % distant tumor inhibition and complete suppression of tumor metastasis. In summary, this innovative approach not only enhances the therapeutic potential of COFs but also opens up new avenues for integrating microbial and nanotechnological strategies in cancer treatment. |
| format | Article |
| id | doaj-art-2885adf7445942cab7cd1b31b8dbb03d |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-2885adf7445942cab7cd1b31b8dbb03d2025-01-26T05:04:27ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-05-0147283294Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapyQi-Chao Yang0Yuan-Yuan Wang1Shuo Wang2An Song3Wen-Da Wang4Liang Zhang5Zhi-Jun Sun6The State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, ChinaThe State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, ChinaThe State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, ChinaThe State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, ChinaThe State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, ChinaCorresponding author.; The State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, ChinaCorresponding author.; The State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, ChinaThe cellular uptake and tissue dispersion efficiency of nanomedicines are crucial for realizing their biological functionality. As a cutting-edge category of nanomedicine, covalent organic frameworks (COFs)-based photosensitizers, have been extensively employed in cancer phototherapy in recent years. However, the inherent aggregation tendency of COFs hinders their uptake by tumor cells and dispersion within tumor tissues, thereby limiting their therapeutic efficacy. In this study, we employed Fusobacterium nucleatum (F.n.), a prevalent intratumoral bacterium, to construct a bacterium membrane-wrapped COF, COF-306@FM, which is readily taken up by cancer cells and uniformly dispersed within tumor tissues. Meanwhile, the F.n. membrane can also serve as an immune adjuvant to warm up the “cold” tumor immune microenvironment by enhancing the CD8+ T and B cells infiltration, and inducing the formation of tumor-located tertiary lymphoid structures. Consequently, the response rate of αPD-L1 immunotherapy was drastically promoted to efficiently prevent tumor metastasis and recurrence, causing 84.6 % distant tumor inhibition and complete suppression of tumor metastasis. In summary, this innovative approach not only enhances the therapeutic potential of COFs but also opens up new avenues for integrating microbial and nanotechnological strategies in cancer treatment.http://www.sciencedirect.com/science/article/pii/S2452199X25000180Covalent organic frameworkImmune adjuvantBacterial membraneCancer immunotherapyTissue dispersion |
| spellingShingle | Qi-Chao Yang Yuan-Yuan Wang Shuo Wang An Song Wen-Da Wang Liang Zhang Zhi-Jun Sun Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy Bioactive Materials Covalent organic framework Immune adjuvant Bacterial membrane Cancer immunotherapy Tissue dispersion |
| title | Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy |
| title_full | Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy |
| title_fullStr | Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy |
| title_full_unstemmed | Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy |
| title_short | Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy |
| title_sort | engineered bacterial membrane biomimetic covalent organic framework as nano immunopotentiator for cancer immunotherapy |
| topic | Covalent organic framework Immune adjuvant Bacterial membrane Cancer immunotherapy Tissue dispersion |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25000180 |
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