Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function
Caveolin-2 is one of the major protein components of cholesterol- and glycosphingolipid-rich flask-shaped invaginations of plasma membrane caveolae. A new body of evidence suggests that caveolin-2 plays an important, and often more direct, role than caveolin-1 in regulating signaling and function in...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2011/809259 |
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| _version_ | 1832550341260869632 |
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| author | Grzegorz Sowa |
| author_facet | Grzegorz Sowa |
| author_sort | Grzegorz Sowa |
| collection | DOAJ |
| description | Caveolin-2 is one of the major protein components of cholesterol- and glycosphingolipid-rich flask-shaped invaginations of plasma membrane caveolae. A new body of evidence suggests that caveolin-2 plays an important, and often more direct, role than caveolin-1 in regulating signaling and function in a cell- and tissue type-specific manner. The purpose of this paper is to primarily focus on discussing how these recent discoveries may help better understand the specific contribution of caveolin-2 to lipid raft- and caveolae-regulated cell/tissue-specific signaling and functions. |
| format | Article |
| id | doaj-art-287db4ba917e482899ae76b4958de689 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-287db4ba917e482899ae76b4958de6892025-02-03T06:07:01ZengWileyBiochemistry Research International2090-22472090-22552011-01-01201110.1155/2011/809259809259Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and FunctionGrzegorz Sowa0Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USACaveolin-2 is one of the major protein components of cholesterol- and glycosphingolipid-rich flask-shaped invaginations of plasma membrane caveolae. A new body of evidence suggests that caveolin-2 plays an important, and often more direct, role than caveolin-1 in regulating signaling and function in a cell- and tissue type-specific manner. The purpose of this paper is to primarily focus on discussing how these recent discoveries may help better understand the specific contribution of caveolin-2 to lipid raft- and caveolae-regulated cell/tissue-specific signaling and functions.http://dx.doi.org/10.1155/2011/809259 |
| spellingShingle | Grzegorz Sowa Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function Biochemistry Research International |
| title | Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function |
| title_full | Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function |
| title_fullStr | Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function |
| title_full_unstemmed | Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function |
| title_short | Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function |
| title_sort | novel insights into the role of caveolin 2 in cell and tissue specific signaling and function |
| url | http://dx.doi.org/10.1155/2011/809259 |
| work_keys_str_mv | AT grzegorzsowa novelinsightsintotheroleofcaveolin2incellandtissuespecificsignalingandfunction |