Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation
Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recip...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/378281 |
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| author | T. M. Haverman J. E. Raber-Durlacher W. M. H. Rademacher S. Vokurka J. B. Epstein C. Huisman M. D. Hazenberg J. J. de Soet J. de Lange F. R. Rozema |
| author_facet | T. M. Haverman J. E. Raber-Durlacher W. M. H. Rademacher S. Vokurka J. B. Epstein C. Huisman M. D. Hazenberg J. J. de Soet J. de Lange F. R. Rozema |
| author_sort | T. M. Haverman |
| collection | DOAJ |
| description | Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and in some cases with increased mortality and may significantly affect quality of life, even many years after HSCT. Inflammatory processes are key in the pathobiology of most oral complications in HSCT recipients. This review article will discuss frequently encountered oral complications associated with HSCT focusing on the inflammatory pathways and inflammatory mediators involved in their pathogenesis. |
| format | Article |
| id | doaj-art-287b216381a2492486f939709ebaa876 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-287b216381a2492486f939709ebaa8762025-02-03T01:01:11ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/378281378281Oral Complications in Hematopoietic Stem Cell Recipients: The Role of InflammationT. M. Haverman0J. E. Raber-Durlacher1W. M. H. Rademacher2S. Vokurka3J. B. Epstein4C. Huisman5M. D. Hazenberg6J. J. de Soet7J. de Lange8F. R. Rozema9Department of Dental Medical Interaction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The NetherlandsDepartment of Oral- and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Dental Medical Interaction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The NetherlandsDepartment of Haemato-Oncology, University Hospital and Charles University Faculty of Medicine Plzen, Alej Svobody 80, 304 60 Pilsen, Czech RepublicSamuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USADepartment of Hematology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Hematology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The NetherlandsDepartment of Oral- and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Dental Medical Interaction, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The NetherlandsHematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and in some cases with increased mortality and may significantly affect quality of life, even many years after HSCT. Inflammatory processes are key in the pathobiology of most oral complications in HSCT recipients. This review article will discuss frequently encountered oral complications associated with HSCT focusing on the inflammatory pathways and inflammatory mediators involved in their pathogenesis.http://dx.doi.org/10.1155/2014/378281 |
| spellingShingle | T. M. Haverman J. E. Raber-Durlacher W. M. H. Rademacher S. Vokurka J. B. Epstein C. Huisman M. D. Hazenberg J. J. de Soet J. de Lange F. R. Rozema Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation Mediators of Inflammation |
| title | Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation |
| title_full | Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation |
| title_fullStr | Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation |
| title_full_unstemmed | Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation |
| title_short | Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation |
| title_sort | oral complications in hematopoietic stem cell recipients the role of inflammation |
| url | http://dx.doi.org/10.1155/2014/378281 |
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