Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2
Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has a range of toxic effects that have seriously affected animal husbandry. Rutin, a natural flavonoid with antioxidant activities, has been studied for its potential involvement in mitigating ZEA-induced apoptosis in porcine endom...
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MDPI AG
2024-12-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/17/1/7 |
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| author | Chuangjiang Chen Chenlong Wang Hui Jiang Mengya Wang Sajid Ur Rahman Changjiang Chen Hongyan Ding Chang Zhao Wanyue Huang Xichun Wang |
| author_facet | Chuangjiang Chen Chenlong Wang Hui Jiang Mengya Wang Sajid Ur Rahman Changjiang Chen Hongyan Ding Chang Zhao Wanyue Huang Xichun Wang |
| author_sort | Chuangjiang Chen |
| collection | DOAJ |
| description | Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has a range of toxic effects that have seriously affected animal husbandry. Rutin, a natural flavonoid with antioxidant activities, has been studied for its potential involvement in mitigating ZEA-induced apoptosis in porcine endometrial stromal cells (ESCs) and its potential molecular mechanism, particularly concerning the expression of Nrf2. This study investigates the molecular pathways by which rutin alleviates ZEA-induced ESC apoptosis, focusing on the role of Nrf2. Experimental data reveal that ZEA suppresses Nrf2 nuclear translocation and reduces mitochondrial membrane potential (MMP), leading to oxidative stress, endoplasmic reticulum stress (ERS), and mitochondrial pathway-driven apoptosis. Notably, rutin mitigates ZEA-induced apoptosis through Nrf2 activation. These findings highlight Nrf2 as a critical factor in rutin’s protective effects against ZEA-induced apoptosis, offering valuable insights for the clinical prevention and treatment of ZEA toxicity. |
| format | Article |
| id | doaj-art-287881974e87482b8de40de09400d37a |
| institution | Kabale University |
| issn | 2072-6651 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj-art-287881974e87482b8de40de09400d37a2025-01-24T13:51:10ZengMDPI AGToxins2072-66512024-12-01171710.3390/toxins17010007Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2Chuangjiang Chen0Chenlong Wang1Hui Jiang2Mengya Wang3Sajid Ur Rahman4Changjiang Chen5Hongyan Ding6Chang Zhao7Wanyue Huang8Xichun Wang9College of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, ChinaCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, ChinaCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, ChinaCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, ChinaSchool of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaHuangyuan County Animal Husbandry and Veterinary Station, Huangyuan County Agriculture and Rural affairs Bureau, Xining 812100, ChinaAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Science and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei 230001, ChinaCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, ChinaCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, ChinaCollege of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, ChinaZearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has a range of toxic effects that have seriously affected animal husbandry. Rutin, a natural flavonoid with antioxidant activities, has been studied for its potential involvement in mitigating ZEA-induced apoptosis in porcine endometrial stromal cells (ESCs) and its potential molecular mechanism, particularly concerning the expression of Nrf2. This study investigates the molecular pathways by which rutin alleviates ZEA-induced ESC apoptosis, focusing on the role of Nrf2. Experimental data reveal that ZEA suppresses Nrf2 nuclear translocation and reduces mitochondrial membrane potential (MMP), leading to oxidative stress, endoplasmic reticulum stress (ERS), and mitochondrial pathway-driven apoptosis. Notably, rutin mitigates ZEA-induced apoptosis through Nrf2 activation. These findings highlight Nrf2 as a critical factor in rutin’s protective effects against ZEA-induced apoptosis, offering valuable insights for the clinical prevention and treatment of ZEA toxicity.https://www.mdpi.com/2072-6651/17/1/7zearalenonerutinNrf2endoplasmic reticulum stressapoptosi |
| spellingShingle | Chuangjiang Chen Chenlong Wang Hui Jiang Mengya Wang Sajid Ur Rahman Changjiang Chen Hongyan Ding Chang Zhao Wanyue Huang Xichun Wang Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 Toxins zearalenone rutin Nrf2 endoplasmic reticulum stress apoptosi |
| title | Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 |
| title_full | Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 |
| title_fullStr | Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 |
| title_full_unstemmed | Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 |
| title_short | Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 |
| title_sort | rutin alleviates zearalenone induced endoplasmic reticulum stress and mitochondrial pathway apoptosis in porcine endometrial stromal cells by promoting the expression of nrf2 |
| topic | zearalenone rutin Nrf2 endoplasmic reticulum stress apoptosi |
| url | https://www.mdpi.com/2072-6651/17/1/7 |
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