Effects of Intrauterine Human Chorionic Gonadotropin on Endometrial Receptivity in Intracytoplasmic Sperm Injection Cycle
Background: Human chorionic gonadotropin (hCG) is one of the chief embryonic signals in primates. It modifies the uterine environment, encourages uterine receptivity, and plays a key role in embryo implantation.Objectives: To determine the impact of intrauterine infusion of hCG at day of ovum pickup...
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University of Anbar
2025-01-01
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| Series: | Al-Anbar Medical Journal |
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| Online Access: | https://amj.uoanbar.edu.iq/article_185673_cee5096d7314d1931232c4e16aa9f902.pdf |
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| author | Omaima Al Dosary Huda Hussaini Manal Al-Obaidi |
| author_facet | Omaima Al Dosary Huda Hussaini Manal Al-Obaidi |
| author_sort | Omaima Al Dosary |
| collection | DOAJ |
| description | Background: Human chorionic gonadotropin (hCG) is one of the chief embryonic signals in primates. It modifies the uterine environment, encourages uterine receptivity, and plays a key role in embryo implantation.Objectives: To determine the impact of intrauterine infusion of hCG at day of ovum pickup on the endometrial receptivity using ultrasound measurement of endometrial thickness and sub-endometrial blood flow indices like resistance index (RI), pulsatility index (PI), and systole/diastole (S/D) ratio, and on improvement of intra-cytoplasmic sperm injection (ICSI) outcome.Material and methods: This comparative study included 90 infertile females from the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Baghdad, Iraq. The patients were randomly classified into three groups: Group A (30 women received intrauterine insemination of 700 IU hCG); Group B (30 women received 500 IU hCG); and Group C (30 women received no intervention). Ultrasound examination and assessment of plasma hormone level on cycle days 2-3 were done for all patients like follicle stimulating hormone, luteinizing hormone, estradiol E2, prolactin, and thyroid stimulating hormone. Embryo transfer, luteal support, and serum beta-hCG on day 14 after embryo transfer were performed, and the pregnancy rate was registered.Result: Group A had significantly lower means for the RI, PI, and S/D ratio than groups B and C (P-value = 0.001, 0.002, and 0.027, respectively). Group A had a significantly higher pregnancy rate (P-value = 0.035) than group C. However, there was no significant difference between groups A and B (P-value > 0.05). Conclusion: Infusion of 700 IU hCG can improve sub-endometrial blood flow by reducing the RI and PI. These effects will improve the pregnancy rate in patients undergoing the ICSI cycle. |
| format | Article |
| id | doaj-art-286de27eac7b4c8788db4865a658aa96 |
| institution | Kabale University |
| issn | 2706-6207 2664-3154 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | University of Anbar |
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| series | Al-Anbar Medical Journal |
| spelling | doaj-art-286de27eac7b4c8788db4865a658aa962025-01-21T21:57:33ZengUniversity of AnbarAl-Anbar Medical Journal2706-62072664-31542025-01-01211677310.33091/amj.2024.153927.1946185673Effects of Intrauterine Human Chorionic Gonadotropin on Endometrial Receptivity in Intracytoplasmic Sperm Injection CycleOmaima Al Dosary0Huda Hussaini1Manal Al-Obaidi2Department of Physiology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq.Department of Radiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq.Department of Physiology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq.Background: Human chorionic gonadotropin (hCG) is one of the chief embryonic signals in primates. It modifies the uterine environment, encourages uterine receptivity, and plays a key role in embryo implantation.Objectives: To determine the impact of intrauterine infusion of hCG at day of ovum pickup on the endometrial receptivity using ultrasound measurement of endometrial thickness and sub-endometrial blood flow indices like resistance index (RI), pulsatility index (PI), and systole/diastole (S/D) ratio, and on improvement of intra-cytoplasmic sperm injection (ICSI) outcome.Material and methods: This comparative study included 90 infertile females from the High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Baghdad, Iraq. The patients were randomly classified into three groups: Group A (30 women received intrauterine insemination of 700 IU hCG); Group B (30 women received 500 IU hCG); and Group C (30 women received no intervention). Ultrasound examination and assessment of plasma hormone level on cycle days 2-3 were done for all patients like follicle stimulating hormone, luteinizing hormone, estradiol E2, prolactin, and thyroid stimulating hormone. Embryo transfer, luteal support, and serum beta-hCG on day 14 after embryo transfer were performed, and the pregnancy rate was registered.Result: Group A had significantly lower means for the RI, PI, and S/D ratio than groups B and C (P-value = 0.001, 0.002, and 0.027, respectively). Group A had a significantly higher pregnancy rate (P-value = 0.035) than group C. However, there was no significant difference between groups A and B (P-value > 0.05). Conclusion: Infusion of 700 IU hCG can improve sub-endometrial blood flow by reducing the RI and PI. These effects will improve the pregnancy rate in patients undergoing the ICSI cycle.https://amj.uoanbar.edu.iq/article_185673_cee5096d7314d1931232c4e16aa9f902.pdfimplantationendometrial receptivityhuman chorionic gonadotropinintracytoplasmic sperm injection cycle |
| spellingShingle | Omaima Al Dosary Huda Hussaini Manal Al-Obaidi Effects of Intrauterine Human Chorionic Gonadotropin on Endometrial Receptivity in Intracytoplasmic Sperm Injection Cycle Al-Anbar Medical Journal implantation endometrial receptivity human chorionic gonadotropin intracytoplasmic sperm injection cycle |
| title | Effects of Intrauterine Human Chorionic Gonadotropin on Endometrial Receptivity in Intracytoplasmic Sperm Injection Cycle |
| title_full | Effects of Intrauterine Human Chorionic Gonadotropin on Endometrial Receptivity in Intracytoplasmic Sperm Injection Cycle |
| title_fullStr | Effects of Intrauterine Human Chorionic Gonadotropin on Endometrial Receptivity in Intracytoplasmic Sperm Injection Cycle |
| title_full_unstemmed | Effects of Intrauterine Human Chorionic Gonadotropin on Endometrial Receptivity in Intracytoplasmic Sperm Injection Cycle |
| title_short | Effects of Intrauterine Human Chorionic Gonadotropin on Endometrial Receptivity in Intracytoplasmic Sperm Injection Cycle |
| title_sort | effects of intrauterine human chorionic gonadotropin on endometrial receptivity in intracytoplasmic sperm injection cycle |
| topic | implantation endometrial receptivity human chorionic gonadotropin intracytoplasmic sperm injection cycle |
| url | https://amj.uoanbar.edu.iq/article_185673_cee5096d7314d1931232c4e16aa9f902.pdf |
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