A Rare Cause of Acute Kidney Injury: Primary Renal Lymphoma in a Patient with Human Immunodeficiency Virus
We reported a case of primary renal lymphoma (PRL) presented with non-oliguric acute kidney injury and bilateral kidney infiltrates in an individual with human immunodeficiency virus (HIV) disease. Acute kidney injury secondary to lymphoma infiltrates is very rare (less than 1% of hematological mali...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/8425985 |
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| author | Ruslinda Mustafar Lydia Kamaruzaman Beh Hui Chien Azyani Yahaya Noor’Ain Mohd Nasir Rozita Mohd Rizna Cader Kong Wei Yen |
| author_facet | Ruslinda Mustafar Lydia Kamaruzaman Beh Hui Chien Azyani Yahaya Noor’Ain Mohd Nasir Rozita Mohd Rizna Cader Kong Wei Yen |
| author_sort | Ruslinda Mustafar |
| collection | DOAJ |
| description | We reported a case of primary renal lymphoma (PRL) presented with non-oliguric acute kidney injury and bilateral kidney infiltrates in an individual with human immunodeficiency virus (HIV) disease. Acute kidney injury secondary to lymphoma infiltrates is very rare (less than 1% of hematological malignancy). A 37-year-old gentleman with underlying human immunodeficiency virus (HIV) disease was on combined antiretroviral therapy since diagnosis. He presented to our center with uremic symptoms and gross hematuria. Clinically, bilateral kidneys massively enlarged and were ballotable. Blood investigations showed hemoglobin of 3.7 g/L, urea of 65.6 mmol/L, and serum creatinine of 1630 µmol/L with hyperkalemia and metabolic acidosis. An urgent hemodialysis was initiated, and he was dependent on regular hemodialysis subsequently. Computed tomography renal scan showed diffuse nonenhancing hypodense lesion in both renal parenchyma. Diagnosis of diffuse large B cell lymphoma with germinal center type, CD20 positive, and proliferative index 95% was confirmed via renal biopsy, and there was no bone marrow infiltrates. Unfortunately, the patient succumbs prior to initiation of chemotherapy. |
| format | Article |
| id | doaj-art-285ca93a09ad4b5cb2c5b00ca3ec492b |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-285ca93a09ad4b5cb2c5b00ca3ec492b2025-02-03T01:22:32ZengWileyCase Reports in Medicine1687-96271687-96352018-01-01201810.1155/2018/84259858425985A Rare Cause of Acute Kidney Injury: Primary Renal Lymphoma in a Patient with Human Immunodeficiency VirusRuslinda Mustafar0Lydia Kamaruzaman1Beh Hui Chien2Azyani Yahaya3Noor’Ain Mohd Nasir4Rozita Mohd5Rizna Cader6Kong Wei Yen7Department of Medicine, Nephrology Unit, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, MalaysiaDepartment of Medicine, Nephrology Unit, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, MalaysiaDepartment of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, MalaysiaDepartment of Pathology, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, MalaysiaDepartment of Pathology, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, MalaysiaDepartment of Medicine, Nephrology Unit, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, MalaysiaDepartment of Medicine, Nephrology Unit, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, MalaysiaDepartment of Medicine, Nephrology Unit, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, MalaysiaWe reported a case of primary renal lymphoma (PRL) presented with non-oliguric acute kidney injury and bilateral kidney infiltrates in an individual with human immunodeficiency virus (HIV) disease. Acute kidney injury secondary to lymphoma infiltrates is very rare (less than 1% of hematological malignancy). A 37-year-old gentleman with underlying human immunodeficiency virus (HIV) disease was on combined antiretroviral therapy since diagnosis. He presented to our center with uremic symptoms and gross hematuria. Clinically, bilateral kidneys massively enlarged and were ballotable. Blood investigations showed hemoglobin of 3.7 g/L, urea of 65.6 mmol/L, and serum creatinine of 1630 µmol/L with hyperkalemia and metabolic acidosis. An urgent hemodialysis was initiated, and he was dependent on regular hemodialysis subsequently. Computed tomography renal scan showed diffuse nonenhancing hypodense lesion in both renal parenchyma. Diagnosis of diffuse large B cell lymphoma with germinal center type, CD20 positive, and proliferative index 95% was confirmed via renal biopsy, and there was no bone marrow infiltrates. Unfortunately, the patient succumbs prior to initiation of chemotherapy.http://dx.doi.org/10.1155/2018/8425985 |
| spellingShingle | Ruslinda Mustafar Lydia Kamaruzaman Beh Hui Chien Azyani Yahaya Noor’Ain Mohd Nasir Rozita Mohd Rizna Cader Kong Wei Yen A Rare Cause of Acute Kidney Injury: Primary Renal Lymphoma in a Patient with Human Immunodeficiency Virus Case Reports in Medicine |
| title | A Rare Cause of Acute Kidney Injury: Primary Renal Lymphoma in a Patient with Human Immunodeficiency Virus |
| title_full | A Rare Cause of Acute Kidney Injury: Primary Renal Lymphoma in a Patient with Human Immunodeficiency Virus |
| title_fullStr | A Rare Cause of Acute Kidney Injury: Primary Renal Lymphoma in a Patient with Human Immunodeficiency Virus |
| title_full_unstemmed | A Rare Cause of Acute Kidney Injury: Primary Renal Lymphoma in a Patient with Human Immunodeficiency Virus |
| title_short | A Rare Cause of Acute Kidney Injury: Primary Renal Lymphoma in a Patient with Human Immunodeficiency Virus |
| title_sort | rare cause of acute kidney injury primary renal lymphoma in a patient with human immunodeficiency virus |
| url | http://dx.doi.org/10.1155/2018/8425985 |
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