Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection
Zinc is an essential micronutrient known to play a vital role in host defense against pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery from and worse outcomes following infection. Sustained insufficient zinc intake leads to dysregulation of the innate immune...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/4315140 |
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| author | Muna Sapkota Daren L. Knoell |
| author_facet | Muna Sapkota Daren L. Knoell |
| author_sort | Muna Sapkota |
| collection | DOAJ |
| description | Zinc is an essential micronutrient known to play a vital role in host defense against pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery from and worse outcomes following infection. Sustained insufficient zinc intake leads to dysregulation of the innate immune response and increases susceptibility to infection whereas zinc supplementation in at-risk populations has been shown to restore host defense and reduce pathogen-related morbidity and mortality. Upon infection, zinc deficiency leads to increased pathology due to imbalance in key signaling networks that result in excessive inflammation and collateral tissue damage. In particular, zinc impacts macrophage function, a critical front-line cell in host defense, in addition to other immune cells. Deficits in zinc adversely impact macrophage function resulting in dysregulation of phagocytosis, intracellular killing, and cytokine production. An additional work in this field has revealed a vital role for several zinc transporter proteins that are required for proper bioredistribution of zinc within mononuclear cells to achieve an optimal immune response against invading microorganisms. In this review, we will discuss the most recent developments regarding zinc’s role in innate immunity and protection against pathogen invasion. |
| format | Article |
| id | doaj-art-28513c3a90e74e46a3567c6d33ef1c70 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-28513c3a90e74e46a3567c6d33ef1c702025-02-03T01:07:20ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/43151404315140Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against InfectionMuna Sapkota0Daren L. Knoell1Department of Pharmacy Practice, College of Pharmacy, 86120 Nebraska Medical Center Omaha, NE 68198-6120, USADepartment of Pharmacy Practice, College of Pharmacy, 86120 Nebraska Medical Center Omaha, NE 68198-6120, USAZinc is an essential micronutrient known to play a vital role in host defense against pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery from and worse outcomes following infection. Sustained insufficient zinc intake leads to dysregulation of the innate immune response and increases susceptibility to infection whereas zinc supplementation in at-risk populations has been shown to restore host defense and reduce pathogen-related morbidity and mortality. Upon infection, zinc deficiency leads to increased pathology due to imbalance in key signaling networks that result in excessive inflammation and collateral tissue damage. In particular, zinc impacts macrophage function, a critical front-line cell in host defense, in addition to other immune cells. Deficits in zinc adversely impact macrophage function resulting in dysregulation of phagocytosis, intracellular killing, and cytokine production. An additional work in this field has revealed a vital role for several zinc transporter proteins that are required for proper bioredistribution of zinc within mononuclear cells to achieve an optimal immune response against invading microorganisms. In this review, we will discuss the most recent developments regarding zinc’s role in innate immunity and protection against pathogen invasion.http://dx.doi.org/10.1155/2018/4315140 |
| spellingShingle | Muna Sapkota Daren L. Knoell Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection Journal of Immunology Research |
| title | Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection |
| title_full | Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection |
| title_fullStr | Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection |
| title_full_unstemmed | Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection |
| title_short | Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection |
| title_sort | essential role of zinc and zinc transporters in myeloid cell function and host defense against infection |
| url | http://dx.doi.org/10.1155/2018/4315140 |
| work_keys_str_mv | AT munasapkota essentialroleofzincandzinctransportersinmyeloidcellfunctionandhostdefenseagainstinfection AT darenlknoell essentialroleofzincandzinctransportersinmyeloidcellfunctionandhostdefenseagainstinfection |