Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases
The cloning of leptin in 1994 by Zhang et al. introduced a novel concept about white adipose tissue (WAT) as a very dynamic organ that releases a plethora of immune and inflammatory mediators, such as adipokines and cytokines, which are involved in multiple diseases. Actually, adipokines exert poten...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2011/290142 |
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| _version_ | 1832552068217307136 |
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| author | Morena Scotece Javier Conde Rodolfo Gómez Veronica López Francisca Lago Juan Jesus Gómez-Reino Oreste Gualillo |
| author_facet | Morena Scotece Javier Conde Rodolfo Gómez Veronica López Francisca Lago Juan Jesus Gómez-Reino Oreste Gualillo |
| author_sort | Morena Scotece |
| collection | DOAJ |
| description | The cloning of leptin in 1994 by Zhang et al. introduced a novel concept about white adipose tissue (WAT) as a very dynamic organ that releases a plethora of immune and inflammatory mediators, such as adipokines and cytokines, which are involved in multiple diseases. Actually, adipokines exert potent modulatory actions on target tissues involved in rheumatic diseases including cartilage, synovial, bone and immune cells. The goal of this paper is to elucidate the recent findings concerning the involvement of adipokines in rheumatic diseases, such as rheumatoid arthritis (RA), osteoarthritis (OA), and systemic lupus erythematosus (SLE). |
| format | Article |
| id | doaj-art-2848173878d64dbda1e4ad6b2ed90f97 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-2848173878d64dbda1e4ad6b2ed90f972025-02-03T05:59:37ZengWileyThe Scientific World Journal1537-744X2011-01-01111932194710.1100/2011/290142290142Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic DiseasesMorena Scotece0Javier Conde1Rodolfo Gómez2Veronica López3Francisca Lago4Juan Jesus Gómez-Reino5Oreste Gualillo6Laboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases (NEIRID LAB), Research Laboratory 9, SERGAS, Institute of Medical Research (IDIS), Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainLaboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases (NEIRID LAB), Research Laboratory 9, SERGAS, Institute of Medical Research (IDIS), Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainDivisión de Reumatología, Fundación Jimenez Díaz, 28040 Madrid, SpainLaboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases (NEIRID LAB), Research Laboratory 9, SERGAS, Institute of Medical Research (IDIS), Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainMolecular and Cellular Cardiology Laboratory, Research Laboratory 7, SERGAS, Institute of Medical Research (IDIS), Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainLaboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases (NEIRID LAB), Research Laboratory 9, SERGAS, Institute of Medical Research (IDIS), Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainLaboratory of Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases (NEIRID LAB), Research Laboratory 9, SERGAS, Institute of Medical Research (IDIS), Santiago University Clinical Hospital, 15706 Santiago de Compostela, SpainThe cloning of leptin in 1994 by Zhang et al. introduced a novel concept about white adipose tissue (WAT) as a very dynamic organ that releases a plethora of immune and inflammatory mediators, such as adipokines and cytokines, which are involved in multiple diseases. Actually, adipokines exert potent modulatory actions on target tissues involved in rheumatic diseases including cartilage, synovial, bone and immune cells. The goal of this paper is to elucidate the recent findings concerning the involvement of adipokines in rheumatic diseases, such as rheumatoid arthritis (RA), osteoarthritis (OA), and systemic lupus erythematosus (SLE).http://dx.doi.org/10.1100/2011/290142 |
| spellingShingle | Morena Scotece Javier Conde Rodolfo Gómez Veronica López Francisca Lago Juan Jesus Gómez-Reino Oreste Gualillo Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases The Scientific World Journal |
| title | Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases |
| title_full | Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases |
| title_fullStr | Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases |
| title_full_unstemmed | Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases |
| title_short | Beyond Fat Mass: Exploring the Role of Adipokines in Rheumatic Diseases |
| title_sort | beyond fat mass exploring the role of adipokines in rheumatic diseases |
| url | http://dx.doi.org/10.1100/2011/290142 |
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