Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system
In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0020 |
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| author | Paul Pijush Kumar Treetong Alongkot Suedee Roongnapa |
| author_facet | Paul Pijush Kumar Treetong Alongkot Suedee Roongnapa |
| author_sort | Paul Pijush Kumar |
| collection | DOAJ |
| description | In this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery. |
| format | Article |
| id | doaj-art-2847ef0c04c442518648110f62611dac |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-2847ef0c04c442518648110f62611dac2025-02-02T11:50:20ZengSciendoActa Pharmaceutica1846-95582017-06-0167214916810.1515/acph-2017-0020acph-2017-0020Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery systemPaul Pijush Kumar0Treetong Alongkot1Suedee Roongnapa2Molecular Recognition Materials Research Unit, Nanotec-PSU Center of Excellence on Drug Delivery System Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hatyai, Songkhla, 90112, ThailandNational Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park Phahonyothin Road Pathum Thani 12120, Pathum Thani, ThailandMolecular Recognition Materials Research Unit, Nanotec-PSU Center of Excellence on Drug Delivery System Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University Hatyai, Songkhla, 90112, ThailandIn this study, we investigate molecularly imprinted polymers (MIPs), which form a three-dimensional image of the region at and around the active binding sites of pharmaceutically active insulin or are analogous to b cells bound to insulin. This approach was employed to create a welldefined structure within the nanospace cavities that make up functional monomers by cross-linking. The obtained MIPs exhibited a high adsorption capacity for the target insulin, which showed a significantly higher release of insulin in solution at pH 7.4 than at pH 1.2. In vivo studies on diabetic Wistar rats showed that the fast onset within 2 h is similar to subcutaneous injection with a maximum at 4 h, giving an engaged function responsible for the duration of glucose reduction for up to 24 h. These MIPs, prepared as nanosized material, may open a new horizon for oral insulin delivery.https://doi.org/10.1515/acph-2017-0020molecularly imprinted polymersinsulinnanoparticlesislet cellsoral drug delivery |
| spellingShingle | Paul Pijush Kumar Treetong Alongkot Suedee Roongnapa Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system Acta Pharmaceutica molecularly imprinted polymers insulin nanoparticles islet cells oral drug delivery |
| title | Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system |
| title_full | Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system |
| title_fullStr | Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system |
| title_full_unstemmed | Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system |
| title_short | Biomimetic insulin-imprinted polymer nanoparticles as a potential oral drug delivery system |
| title_sort | biomimetic insulin imprinted polymer nanoparticles as a potential oral drug delivery system |
| topic | molecularly imprinted polymers insulin nanoparticles islet cells oral drug delivery |
| url | https://doi.org/10.1515/acph-2017-0020 |
| work_keys_str_mv | AT paulpijushkumar biomimeticinsulinimprintedpolymernanoparticlesasapotentialoraldrugdeliverysystem AT treetongalongkot biomimeticinsulinimprintedpolymernanoparticlesasapotentialoraldrugdeliverysystem AT suedeeroongnapa biomimeticinsulinimprintedpolymernanoparticlesasapotentialoraldrugdeliverysystem |