In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer’s disease, and epilepsy p...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/9847696 |
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| author | Harry Pantazopoulos Sabina Berretta |
| author_facet | Harry Pantazopoulos Sabina Berretta |
| author_sort | Harry Pantazopoulos |
| collection | DOAJ |
| description | Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer’s disease, and epilepsy point to the involvement of ECM molecules such as chondroitin sulfate proteoglycans, Reelin, and matrix metalloproteases, as well as their cell surface receptors. In many of these disorders, PNN abnormalities have also been reported. In the context of the “quadripartite” synapse concept, that is, the functional unit composed of the pre- and postsynaptic terminals, glial processes, and ECM, and of the role that PNNs and ECM molecules play in regulating synaptic functions and plasticity, these findings resonate with one of the most well-replicated aspects of the pathology of psychiatric disorders, that is, synaptic abnormalities. Here we review the evidence for PNN/ECM-related pathology in these disorders, with particular emphasis on schizophrenia, and discuss the hypothesis that such pathology may significantly contribute to synaptic dysfunction. |
| format | Article |
| id | doaj-art-28433f10d72a4436910c3b24ad7f8242 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-28433f10d72a4436910c3b24ad7f82422025-02-03T01:29:00ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/98476969847696In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric DisordersHarry Pantazopoulos0Sabina Berretta1Translational Neuroscience Laboratory, Mclean Hospital, Belmont, MA 02478, USATranslational Neuroscience Laboratory, Mclean Hospital, Belmont, MA 02478, USARapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix (ECM) molecules that compose or interact with PNNs, in the pathophysiology of several psychiatric disorders. Studies on schizophrenia, autism spectrum disorders, mood disorders, Alzheimer’s disease, and epilepsy point to the involvement of ECM molecules such as chondroitin sulfate proteoglycans, Reelin, and matrix metalloproteases, as well as their cell surface receptors. In many of these disorders, PNN abnormalities have also been reported. In the context of the “quadripartite” synapse concept, that is, the functional unit composed of the pre- and postsynaptic terminals, glial processes, and ECM, and of the role that PNNs and ECM molecules play in regulating synaptic functions and plasticity, these findings resonate with one of the most well-replicated aspects of the pathology of psychiatric disorders, that is, synaptic abnormalities. Here we review the evidence for PNN/ECM-related pathology in these disorders, with particular emphasis on schizophrenia, and discuss the hypothesis that such pathology may significantly contribute to synaptic dysfunction.http://dx.doi.org/10.1155/2016/9847696 |
| spellingShingle | Harry Pantazopoulos Sabina Berretta In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders Neural Plasticity |
| title | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
| title_full | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
| title_fullStr | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
| title_full_unstemmed | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
| title_short | In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders |
| title_sort | in sickness and in health perineuronal nets and synaptic plasticity in psychiatric disorders |
| url | http://dx.doi.org/10.1155/2016/9847696 |
| work_keys_str_mv | AT harrypantazopoulos insicknessandinhealthperineuronalnetsandsynapticplasticityinpsychiatricdisorders AT sabinaberretta insicknessandinhealthperineuronalnetsandsynapticplasticityinpsychiatricdisorders |