ETosis: A Microbicidal Mechanism beyond Cell Death
Netosis is a recently described type of neutrophil death occurring with the release to the extracellular milieu of a lattice composed of DNA associated with histones and granular and cytoplasmic proteins. These webs, initially named neutrophil extracellular traps (NETs), ensnare and kill microorgani...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2012/929743 |
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| author | Anderson B. Guimarães-Costa Michelle T. C. Nascimento Amanda B. Wardini Lucia H. Pinto-da-Silva Elvira M. Saraiva |
| author_facet | Anderson B. Guimarães-Costa Michelle T. C. Nascimento Amanda B. Wardini Lucia H. Pinto-da-Silva Elvira M. Saraiva |
| author_sort | Anderson B. Guimarães-Costa |
| collection | DOAJ |
| description | Netosis is a recently described type of neutrophil death occurring with the release to the extracellular milieu of a lattice composed of DNA associated with histones and granular and cytoplasmic proteins. These webs, initially named neutrophil extracellular traps (NETs), ensnare and kill microorganisms. Similarly, other cell types, such as eosinophils, mast cells, and macrophages, can also dye by this mechanism; thus, it was renamed as ETosis, meaning death with release of extracellular traps (ETs). Here, we review the mechanism of NETosis/etosis, emphasizing its role in diseases caused by protozoan parasites, fungi, and viruses. |
| format | Article |
| id | doaj-art-283e3520702c49f49428bde78e3402da |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-283e3520702c49f49428bde78e3402da2025-02-03T01:21:07ZengWileyJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/929743929743ETosis: A Microbicidal Mechanism beyond Cell DeathAnderson B. Guimarães-Costa0Michelle T. C. Nascimento1Amanda B. Wardini2Lucia H. Pinto-da-Silva3Elvira M. Saraiva4Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), 21941-901 Rio de Janeiro, RJ, BrazilInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), 21941-901 Rio de Janeiro, RJ, BrazilInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), 21941-901 Rio de Janeiro, RJ, BrazilInstituto de Veterinária, Universidade Federal Rural do Rio de Janeiro (UFRRJ), 23890-000 Seropedica, RJ, BrazilInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), 21941-901 Rio de Janeiro, RJ, BrazilNetosis is a recently described type of neutrophil death occurring with the release to the extracellular milieu of a lattice composed of DNA associated with histones and granular and cytoplasmic proteins. These webs, initially named neutrophil extracellular traps (NETs), ensnare and kill microorganisms. Similarly, other cell types, such as eosinophils, mast cells, and macrophages, can also dye by this mechanism; thus, it was renamed as ETosis, meaning death with release of extracellular traps (ETs). Here, we review the mechanism of NETosis/etosis, emphasizing its role in diseases caused by protozoan parasites, fungi, and viruses.http://dx.doi.org/10.1155/2012/929743 |
| spellingShingle | Anderson B. Guimarães-Costa Michelle T. C. Nascimento Amanda B. Wardini Lucia H. Pinto-da-Silva Elvira M. Saraiva ETosis: A Microbicidal Mechanism beyond Cell Death Journal of Parasitology Research |
| title | ETosis: A Microbicidal Mechanism beyond Cell Death |
| title_full | ETosis: A Microbicidal Mechanism beyond Cell Death |
| title_fullStr | ETosis: A Microbicidal Mechanism beyond Cell Death |
| title_full_unstemmed | ETosis: A Microbicidal Mechanism beyond Cell Death |
| title_short | ETosis: A Microbicidal Mechanism beyond Cell Death |
| title_sort | etosis a microbicidal mechanism beyond cell death |
| url | http://dx.doi.org/10.1155/2012/929743 |
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