Isolation of a tumor neoantigen specific CD8+ TCR from a skin biopsy of a vaccination site

Isolation of a tumor neoantigen specific CD8+ TCR from a skin biopsy of a vaccination site

T cells that recognize tumor-specific mutations are crucial for cancer immunosurveillance and in adoptive transfer of TILs or transgenic-TCR T cell products. However, their challenging identification and isolation limits their use in clinical practice. Therefore, novel approaches to isolate tumor-sp...

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Bibliographic Details
Main Authors: Maria Paula Roberti, Pornpimol Charoentong, Yanhong Lyu, Marten Meyer, Stefan B. Eichmüller, Patrick Schmidt, Frank Momburg, Miray Cetin, Felix Hartmann, Nektarios A. Valous, Albrecht Stenzinger, Laura Michel, Peter Lichter, Andreas Schneeweiss, Verena Thewes, Carlo Fremd, Inka Zörnig, Dirk Jäger
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Breast cancer
adoptive T cell therapy
neoantigen
T cell receptor engineered T cells
peptide vaccine
vaccination site infiltrating lymphocytes
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2457793
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