NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to Caloric Deprivation
Background. Brain natriuretic peptide and its inactive fragment N-terminal pro-BNP (N-BNP) are reliable markers of ventricular dysfunction in adults and children. We analyzed the impact of nutritional state on N-BNP levels in infants with failure to thrive (FTT) and in infants with severe heart fail...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2010/983468 |
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| author | L. B. Mänhardt K. Norozi C. Müller C. Willaschek B. Kostuch R. Buchhorn |
| author_facet | L. B. Mänhardt K. Norozi C. Müller C. Willaschek B. Kostuch R. Buchhorn |
| author_sort | L. B. Mänhardt |
| collection | DOAJ |
| description | Background. Brain natriuretic peptide and its inactive fragment N-terminal pro-BNP (N-BNP) are reliable markers of ventricular dysfunction in adults and children. We analyzed the impact of nutritional state on N-BNP levels in infants with failure to thrive (FTT) and in infants with severe heart failure (HF). The purpose of this study was to compare N-BNP levels in infants with FTT with infants with severe HF and healthy controls.
Methods. In a retrospective cohort study, we compared N-BNP levels from all consecutive infants with FTT and bodyweight below the tenth percentile (caloric deprivation (CD) group) to infants with severe HF. Reference values from infants between 2 and 12 month were taken from the literature and healthy infants. Results. Our results show that infants with FTT (n=15) had significantly (P<.001) elevated N-BNP values compared with the healthy infants (n=23), 530 (119–3150) pg/mL versus 115 (15–1121) pg/mL. N-BNP values in this CD group are comparable to the median value of infants with severe HF (n=12) 673 (408–11310) pg/mL. There is no statistical significant difference in age. Conclusion. Nutritional state has an important impact on N-BNP levels in infants with FTT. We could show comparable levels of N-BNP in infants with FTT and infants with severe HF. |
| format | Article |
| id | doaj-art-281c732957844cb18104f214c8aa9003 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-281c732957844cb18104f214c8aa90032025-02-03T05:43:44ZengWileyInternational Journal of Pediatrics1687-97401687-97592010-01-01201010.1155/2010/983468983468NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to Caloric DeprivationL. B. Mänhardt0K. Norozi1C. Müller2C. Willaschek3B. Kostuch4R. Buchhorn5Department of Paediatrics, Caritas Krankenhaus, Uhlandstraße. 7, 97980 Bad Mergentheim, GermanyDepartment of Paediatrics, London Health Sciences Centre, London, ON, N6A 5Wg, CanadaDepartment of Paediatrics, Caritas Krankenhaus, Uhlandstraße. 7, 97980 Bad Mergentheim, GermanyDepartment of Paediatrics, Caritas Krankenhaus, Uhlandstraße. 7, 97980 Bad Mergentheim, GermanyDepartment of Laboratory Medicine, Caritas Krankenhaus, Uhlandstraße. 7, 97980 Bad Mergentheim, GermanyDepartment of Paediatrics, Caritas Krankenhaus, Uhlandstraße. 7, 97980 Bad Mergentheim, GermanyBackground. Brain natriuretic peptide and its inactive fragment N-terminal pro-BNP (N-BNP) are reliable markers of ventricular dysfunction in adults and children. We analyzed the impact of nutritional state on N-BNP levels in infants with failure to thrive (FTT) and in infants with severe heart failure (HF). The purpose of this study was to compare N-BNP levels in infants with FTT with infants with severe HF and healthy controls. Methods. In a retrospective cohort study, we compared N-BNP levels from all consecutive infants with FTT and bodyweight below the tenth percentile (caloric deprivation (CD) group) to infants with severe HF. Reference values from infants between 2 and 12 month were taken from the literature and healthy infants. Results. Our results show that infants with FTT (n=15) had significantly (P<.001) elevated N-BNP values compared with the healthy infants (n=23), 530 (119–3150) pg/mL versus 115 (15–1121) pg/mL. N-BNP values in this CD group are comparable to the median value of infants with severe HF (n=12) 673 (408–11310) pg/mL. There is no statistical significant difference in age. Conclusion. Nutritional state has an important impact on N-BNP levels in infants with FTT. We could show comparable levels of N-BNP in infants with FTT and infants with severe HF.http://dx.doi.org/10.1155/2010/983468 |
| spellingShingle | L. B. Mänhardt K. Norozi C. Müller C. Willaschek B. Kostuch R. Buchhorn NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to Caloric Deprivation International Journal of Pediatrics |
| title | NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to Caloric Deprivation |
| title_full | NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to Caloric Deprivation |
| title_fullStr | NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to Caloric Deprivation |
| title_full_unstemmed | NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to Caloric Deprivation |
| title_short | NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to Caloric Deprivation |
| title_sort | nt pro b type natriuretic peptide levels in infants with failure to thrive due to caloric deprivation |
| url | http://dx.doi.org/10.1155/2010/983468 |
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