Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation?
We investigated gender differences in the histopathologic presentation of bladder cancer cases in Egypt, where both urothelial cell carcinoma (UC) and squamous cell carcinoma (SCC) types are highly prevalent. We used logistic regression to estimate the unadjusted (OR) and adjusted odds ratio (AOR) a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2018/3453808 |
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| author | Fiorina Kyritsi Christopher A. Loffredo Yun-Ling Zheng George Philips Sania Amr |
| author_facet | Fiorina Kyritsi Christopher A. Loffredo Yun-Ling Zheng George Philips Sania Amr |
| author_sort | Fiorina Kyritsi |
| collection | DOAJ |
| description | We investigated gender differences in the histopathologic presentation of bladder cancer cases in Egypt, where both urothelial cell carcinoma (UC) and squamous cell carcinoma (SCC) types are highly prevalent. We used logistic regression to estimate the unadjusted (OR) and adjusted odds ratio (AOR) and 95% confidence interval (CI) of the associations between gender and different histopathologic and sociodemographic parameters of 2,186 confirmed cases of primary bladder cancer (1,775 males and 411 females; 784 SCC and 1,402 UC). There were no statistically significant gender differences in tumor grade, stage, mucosal ulcer, or inflammatory cystitis, regardless of the cancer type, but men were less likely than women to have undergone cystectomy with pelvic lymphadenectomy. Having Schistosoma haematobium (SH) ova in the bladder tissue was significantly associated with male gender in the fully adjusted model of either SCC (AOR (95% CI) = 2.12 (1.15–3.89)) or UC cases (3.78 (1.89–7.55)). Compared to females, male cases were significantly older at time of diagnosis and smokers. In Egypt, regardless of the type of bladder cancer (SCC or UC), male more than female cases had evidence of SH infection, but not other histopathologic differences, in bladder tissue specimens. |
| format | Article |
| id | doaj-art-280c144bbb02485fbdb11b427c49275a |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-280c144bbb02485fbdb11b427c49275a2025-02-03T01:31:56ZengWileyAdvances in Urology1687-63691687-63772018-01-01201810.1155/2018/34538083453808Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation?Fiorina Kyritsi0Christopher A. Loffredo1Yun-Ling Zheng2George Philips3Sania Amr4Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USALombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USALombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USALombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USAUniversity of Maryland School of Medicine, Baltimore, MD, USAWe investigated gender differences in the histopathologic presentation of bladder cancer cases in Egypt, where both urothelial cell carcinoma (UC) and squamous cell carcinoma (SCC) types are highly prevalent. We used logistic regression to estimate the unadjusted (OR) and adjusted odds ratio (AOR) and 95% confidence interval (CI) of the associations between gender and different histopathologic and sociodemographic parameters of 2,186 confirmed cases of primary bladder cancer (1,775 males and 411 females; 784 SCC and 1,402 UC). There were no statistically significant gender differences in tumor grade, stage, mucosal ulcer, or inflammatory cystitis, regardless of the cancer type, but men were less likely than women to have undergone cystectomy with pelvic lymphadenectomy. Having Schistosoma haematobium (SH) ova in the bladder tissue was significantly associated with male gender in the fully adjusted model of either SCC (AOR (95% CI) = 2.12 (1.15–3.89)) or UC cases (3.78 (1.89–7.55)). Compared to females, male cases were significantly older at time of diagnosis and smokers. In Egypt, regardless of the type of bladder cancer (SCC or UC), male more than female cases had evidence of SH infection, but not other histopathologic differences, in bladder tissue specimens.http://dx.doi.org/10.1155/2018/3453808 |
| spellingShingle | Fiorina Kyritsi Christopher A. Loffredo Yun-Ling Zheng George Philips Sania Amr Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation? Advances in Urology |
| title | Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation? |
| title_full | Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation? |
| title_fullStr | Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation? |
| title_full_unstemmed | Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation? |
| title_short | Urinary Bladder Cancer in Egypt: Are There Gender Differences in Its Histopathological Presentation? |
| title_sort | urinary bladder cancer in egypt are there gender differences in its histopathological presentation |
| url | http://dx.doi.org/10.1155/2018/3453808 |
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