The Effect of Inflammation on the Formation of Thyroid Nodules
Background. Some studies have demonstrated that inflammation is highly associated with the prevalence of thyroid nodules (TNs). However, more confounders, such as metabolic diseases, should be adjusted. Methods. A clinical study collecting 2722 subjects was conducted to confirm the association betwe...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/9827349 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546859570167808 |
|---|---|
| author | Zexin Li Yiteng Huang Xiang Chen Chiju Wei Peixuan Yang Wencan Xu |
| author_facet | Zexin Li Yiteng Huang Xiang Chen Chiju Wei Peixuan Yang Wencan Xu |
| author_sort | Zexin Li |
| collection | DOAJ |
| description | Background. Some studies have demonstrated that inflammation is highly associated with the prevalence of thyroid nodules (TNs). However, more confounders, such as metabolic diseases, should be adjusted. Methods. A clinical study collecting 2722 subjects was conducted to confirm the association between inflammation and TNs. The underlying mechanism was investigated in combination with bioinformatics analysis. Results. In the clinical study, propensity score matching was used to match metabolic parameters and other confounders, and it is observed that subjects with high inflammation had a higher prevalence of TNs and thyroid-stimulating hormone (TSH) than those with low inflammation. After further matching TNs, it is found that inflammation was positively associated with TSH, which was also demonstrated in a population without TNs. In bioinformatics study, inflammation did not promote TNs formation directly. Instead, it inhibited the synthesis of thyroid hormone, which might be the cause of the elevated TSH coexisting with inflammation. Conclusion. Inflammation promotes the development of TNs disease, probably due to its indirect effect through inhibiting the synthesis of thyroid hormone, which results in the elevation of TSH. |
| format | Article |
| id | doaj-art-280b81f84d464e7da2f92cc6e99df6b0 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-280b81f84d464e7da2f92cc6e99df6b02025-02-03T06:46:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/98273499827349The Effect of Inflammation on the Formation of Thyroid NodulesZexin Li0Yiteng Huang1Xiang Chen2Chiju Wei3Peixuan Yang4Wencan Xu5Health Care Center, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, ChinaHealth Care Center, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, ChinaHealth Care Center, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, ChinaMultidisciplinary Research Center, Shantou University, Shantou 515041, ChinaHealth Care Center, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, ChinaBackground. Some studies have demonstrated that inflammation is highly associated with the prevalence of thyroid nodules (TNs). However, more confounders, such as metabolic diseases, should be adjusted. Methods. A clinical study collecting 2722 subjects was conducted to confirm the association between inflammation and TNs. The underlying mechanism was investigated in combination with bioinformatics analysis. Results. In the clinical study, propensity score matching was used to match metabolic parameters and other confounders, and it is observed that subjects with high inflammation had a higher prevalence of TNs and thyroid-stimulating hormone (TSH) than those with low inflammation. After further matching TNs, it is found that inflammation was positively associated with TSH, which was also demonstrated in a population without TNs. In bioinformatics study, inflammation did not promote TNs formation directly. Instead, it inhibited the synthesis of thyroid hormone, which might be the cause of the elevated TSH coexisting with inflammation. Conclusion. Inflammation promotes the development of TNs disease, probably due to its indirect effect through inhibiting the synthesis of thyroid hormone, which results in the elevation of TSH.http://dx.doi.org/10.1155/2020/9827349 |
| spellingShingle | Zexin Li Yiteng Huang Xiang Chen Chiju Wei Peixuan Yang Wencan Xu The Effect of Inflammation on the Formation of Thyroid Nodules International Journal of Endocrinology |
| title | The Effect of Inflammation on the Formation of Thyroid Nodules |
| title_full | The Effect of Inflammation on the Formation of Thyroid Nodules |
| title_fullStr | The Effect of Inflammation on the Formation of Thyroid Nodules |
| title_full_unstemmed | The Effect of Inflammation on the Formation of Thyroid Nodules |
| title_short | The Effect of Inflammation on the Formation of Thyroid Nodules |
| title_sort | effect of inflammation on the formation of thyroid nodules |
| url | http://dx.doi.org/10.1155/2020/9827349 |
| work_keys_str_mv | AT zexinli theeffectofinflammationontheformationofthyroidnodules AT yitenghuang theeffectofinflammationontheformationofthyroidnodules AT xiangchen theeffectofinflammationontheformationofthyroidnodules AT chijuwei theeffectofinflammationontheformationofthyroidnodules AT peixuanyang theeffectofinflammationontheformationofthyroidnodules AT wencanxu theeffectofinflammationontheformationofthyroidnodules AT zexinli effectofinflammationontheformationofthyroidnodules AT yitenghuang effectofinflammationontheformationofthyroidnodules AT xiangchen effectofinflammationontheformationofthyroidnodules AT chijuwei effectofinflammationontheformationofthyroidnodules AT peixuanyang effectofinflammationontheformationofthyroidnodules AT wencanxu effectofinflammationontheformationofthyroidnodules |