Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers
Long non-coding RNAs (lncRNAs) are known to play vital roles in human cancers. LncRNA TRPM2-AS has been found to be upregulated in various types of cancers. The elevated levels of TRPM2-AS are associated with important clinicopathological parameters such as tumor size, tumor stage, and lymph node me...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338251315625 |
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| author | Shichen Huang MS Bowen Li MS Huanyu Chen MD Cheng Rong Zheng Yang MD Xianqin Zhang PhD |
| author_facet | Shichen Huang MS Bowen Li MS Huanyu Chen MD Cheng Rong Zheng Yang MD Xianqin Zhang PhD |
| author_sort | Shichen Huang MS |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are known to play vital roles in human cancers. LncRNA TRPM2-AS has been found to be upregulated in various types of cancers. The elevated levels of TRPM2-AS are associated with important clinicopathological parameters such as tumor size, tumor stage, and lymph node metastasis, revealing that TRPM2-AS could be a potential target for cancer diagnosis, prognosis and treatment. Moreover, TRPM2-AS is involved in regulating the cell proliferation, migration, invasion, apoptosis, drug or radio resistance by serving as a competing endogenous RNA, directly bounding to proteins and regulating multiple signaling pathways. In this review, we comprehensively summarize the latest knowledge on the aberrant expression of TRPM2-AS, the relationship between TRPM2-AS and clinical features, and the detailed mechanisms of potential functions of TRPM2-AS in various cancer types. The current study highlights the potential of TRPM2-AS as a prognostic and therapeutic target in cancers. |
| format | Article |
| id | doaj-art-280678df8f4646648c6ea93d9cb7ba22 |
| institution | Kabale University |
| issn | 1533-0338 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj-art-280678df8f4646648c6ea93d9cb7ba222025-01-27T13:03:45ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382025-01-012410.1177/15330338251315625Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in CancersShichen Huang MS0Bowen Li MS1Huanyu Chen MD2Cheng Rong3Zheng Yang MD4Xianqin Zhang PhD5 School of Clinical Medicine, , 783 Xindu Avenue, Chengdu, 610500, Sichuan, China School of Clinical Medicine, , 783 Xindu Avenue, Chengdu, 610500, Sichuan, China School of Basic Medical Sciences, , 783 Xindu Avenue, Chengdu, 610500, Sichuan, China School of Basic Medical Sciences, , 783 Xindu Avenue, Chengdu, 610500, Sichuan, China School of Basic Medical Sciences, , 783 Xindu Avenue, Chengdu, 610500, Sichuan, China School of Basic Medical Sciences, , 783 Xindu Avenue, Chengdu, 610500, Sichuan, ChinaLong non-coding RNAs (lncRNAs) are known to play vital roles in human cancers. LncRNA TRPM2-AS has been found to be upregulated in various types of cancers. The elevated levels of TRPM2-AS are associated with important clinicopathological parameters such as tumor size, tumor stage, and lymph node metastasis, revealing that TRPM2-AS could be a potential target for cancer diagnosis, prognosis and treatment. Moreover, TRPM2-AS is involved in regulating the cell proliferation, migration, invasion, apoptosis, drug or radio resistance by serving as a competing endogenous RNA, directly bounding to proteins and regulating multiple signaling pathways. In this review, we comprehensively summarize the latest knowledge on the aberrant expression of TRPM2-AS, the relationship between TRPM2-AS and clinical features, and the detailed mechanisms of potential functions of TRPM2-AS in various cancer types. The current study highlights the potential of TRPM2-AS as a prognostic and therapeutic target in cancers.https://doi.org/10.1177/15330338251315625 |
| spellingShingle | Shichen Huang MS Bowen Li MS Huanyu Chen MD Cheng Rong Zheng Yang MD Xianqin Zhang PhD Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers Technology in Cancer Research & Treatment |
| title | Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers |
| title_full | Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers |
| title_fullStr | Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers |
| title_full_unstemmed | Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers |
| title_short | Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers |
| title_sort | clinical significance and pathogenic mechanisms of long non coding rna trpm2 as in cancers |
| url | https://doi.org/10.1177/15330338251315625 |
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