Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice
We examined the effect of the acetylcholinesterase (ACHE) inhibitor, donepezil hydrocloride (DONP), on group II metabotropic glutamate (mGlu) receptor agonist- or antagonist-induced amnesia in the step-through passive avoidance task in male mice. DCG-IV, a group II mGlu receptor agonist, at dose of...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2003.319 |
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| _version_ | 1832567499532533760 |
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| author | Tomoaki Sato Koh-ichi Tanaka Yoshiko Ohnishi Masahiro Irifune Takashige Nishikawa |
| author_facet | Tomoaki Sato Koh-ichi Tanaka Yoshiko Ohnishi Masahiro Irifune Takashige Nishikawa |
| author_sort | Tomoaki Sato |
| collection | DOAJ |
| description | We examined the effect of the acetylcholinesterase
(ACHE) inhibitor, donepezil
hydrocloride (DONP), on group II metabotropic
glutamate (mGlu) receptor agonist- or
antagonist-induced amnesia in the step-through
passive avoidance task in male mice. DCG-IV, a
group II mGlu receptor agonist, at dose of 50
ng and LY341495, a group II mGlu receptor
antagonist, at dose of 300 ng, significantly
attenuated the latency on the step-through task.
The subcutaneous injection of DONP at dose of
1 mg/kg 1 hour before passive avoidance
performance ameliorated the amnesia induced
by DCG-IV and LY341495, whereas donepezil
alone did not affect task latency. The results
suggest that activation of group II mGlu
receptors and disinhibition of the cAMP/PKA
signaling pathway (caused by group II mGlu
receptor antagonist) have a negative action on
step-through passive avoidance memory
performance, and that group II mGlu receptors
and ACh interact to modulate learning and
memory function. |
| format | Article |
| id | doaj-art-27f4a9ecbe9b4871b959c338c43c85ed |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-27f4a9ecbe9b4871b959c338c43c85ed2025-02-03T01:01:12ZengWileyNeural Plasticity2090-59041687-54432003-01-0110431932510.1155/NP.2003.319Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in MiceTomoaki Sato0Koh-ichi Tanaka1Yoshiko Ohnishi2Masahiro Irifune3Takashige Nishikawa4Department of Applied Pharmacology, Kagoshima University Graduate School of Medical & Dental Sciences, Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical & Dental Sciences, Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical & Dental Sciences, Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Anesthesiology, Hiroshima University Dental Hospital, Kasumi, Minami-ku, Hiroshima 734-8533, JapanDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical & Dental Sciences, Sakuragaoka, Kagoshima 890-8544, JapanWe examined the effect of the acetylcholinesterase (ACHE) inhibitor, donepezil hydrocloride (DONP), on group II metabotropic glutamate (mGlu) receptor agonist- or antagonist-induced amnesia in the step-through passive avoidance task in male mice. DCG-IV, a group II mGlu receptor agonist, at dose of 50 ng and LY341495, a group II mGlu receptor antagonist, at dose of 300 ng, significantly attenuated the latency on the step-through task. The subcutaneous injection of DONP at dose of 1 mg/kg 1 hour before passive avoidance performance ameliorated the amnesia induced by DCG-IV and LY341495, whereas donepezil alone did not affect task latency. The results suggest that activation of group II mGlu receptors and disinhibition of the cAMP/PKA signaling pathway (caused by group II mGlu receptor antagonist) have a negative action on step-through passive avoidance memory performance, and that group II mGlu receptors and ACh interact to modulate learning and memory function.http://dx.doi.org/10.1155/NP.2003.319 |
| spellingShingle | Tomoaki Sato Koh-ichi Tanaka Yoshiko Ohnishi Masahiro Irifune Takashige Nishikawa Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice Neural Plasticity |
| title | Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice |
| title_full | Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice |
| title_fullStr | Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice |
| title_full_unstemmed | Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice |
| title_short | Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice |
| title_sort | effect of donepezil on group ii mglu receptor agonist or antagonist induced amnesia on passive avoidance in mice |
| url | http://dx.doi.org/10.1155/NP.2003.319 |
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