Nuclear mRNA export
In eukaryotic cells, gene expression begins with transcription in the nucleus, followed by the maturation of messenger RNAs (mRNAs). These mRNA molecules are then exported to the cytoplasm through the nuclear pore complex (NPC), a process t...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-09-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024145 |
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| author | Chen Suli Jiang Qingyi Fan Jing Cheng Hong |
| author_facet | Chen Suli Jiang Qingyi Fan Jing Cheng Hong |
| author_sort | Chen Suli |
| collection | DOAJ |
| description | In eukaryotic cells, gene expression begins with transcription in the nucleus, followed by the maturation of messenger RNAs (mRNAs). These mRNA molecules are then exported to the cytoplasm through the nuclear pore complex (NPC), a process that serves as a critical regulatory phase of gene expression. The export of mRNA is intricately linked to precursor mRNA (pre-mRNA) processing, ensuring that only properly processed mRNA reaches the cytoplasm. This coordination is essential, as recent studies have revealed that mRNA export factors not only assist in transport but also influence upstream processing steps, adding a layer of complexity to gene regulation. Furthermore, the export process competes with RNA processing and degradation pathways, maintaining a delicate balance vital for accurate gene expression. While these mechanisms are generally conserved across eukaryotes, significant differences exist between yeast and higher eukaryotic cells, particularly due to the more genome complexity of the latter. This review delves into the current research on mRNA export in higher eukaryotic cells, focusing on its role in the broader context of gene expression regulation and highlighting how it interacts with other gene expression processes to ensure precise and efficient gene functionality in complex organisms. |
| format | Article |
| id | doaj-art-27e8fc7ea5874bdc9f7b31b86efe05c8 |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-27e8fc7ea5874bdc9f7b31b86efe05c82025-01-24T00:56:43ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-09-01578410010.3724/abbs.202414520d259ccNuclear mRNA exportChen Suli0Jiang Qingyi1Fan Jing2Cheng Hong3["Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China"]["Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"]["Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China","The Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China"]["Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China","Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"]In eukaryotic cells, gene expression begins with transcription in the nucleus, followed by the maturation of messenger RNAs (mRNAs). These mRNA molecules are then exported to the cytoplasm through the nuclear pore complex (NPC), a process that serves as a critical regulatory phase of gene expression. The export of mRNA is intricately linked to precursor mRNA (pre-mRNA) processing, ensuring that only properly processed mRNA reaches the cytoplasm. This coordination is essential, as recent studies have revealed that mRNA export factors not only assist in transport but also influence upstream processing steps, adding a layer of complexity to gene regulation. Furthermore, the export process competes with RNA processing and degradation pathways, maintaining a delicate balance vital for accurate gene expression. While these mechanisms are generally conserved across eukaryotes, significant differences exist between yeast and higher eukaryotic cells, particularly due to the more genome complexity of the latter. This review delves into the current research on mRNA export in higher eukaryotic cells, focusing on its role in the broader context of gene expression regulation and highlighting how it interacts with other gene expression processes to ensure precise and efficient gene functionality in complex organisms.https://www.sciengine.com/doi/10.3724/abbs.2024145mRNA exportmRNA processingorchestrate regulationgene expression |
| spellingShingle | Chen Suli Jiang Qingyi Fan Jing Cheng Hong Nuclear mRNA export Acta Biochimica et Biophysica Sinica mRNA export mRNA processing orchestrate regulation gene expression |
| title | Nuclear mRNA export |
| title_full | Nuclear mRNA export |
| title_fullStr | Nuclear mRNA export |
| title_full_unstemmed | Nuclear mRNA export |
| title_short | Nuclear mRNA export |
| title_sort | nuclear mrna export |
| topic | mRNA export mRNA processing orchestrate regulation gene expression |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024145 |
| work_keys_str_mv | AT chensuli nuclearmrnaexport AT jiangqingyi nuclearmrnaexport AT fanjing nuclearmrnaexport AT chenghong nuclearmrnaexport |