The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways
Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking. Rab proteins alternate between an activated (GTP-bound) state and an inactivated (GDP-bound) state. Early endosome marker Rab5 G...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2020/4186308 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561134847131648 |
|---|---|
| author | Wanqiong Yuan Chunli Song |
| author_facet | Wanqiong Yuan Chunli Song |
| author_sort | Wanqiong Yuan |
| collection | DOAJ |
| description | Ras analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking. Rab proteins alternate between an activated (GTP-bound) state and an inactivated (GDP-bound) state. Early endosome marker Rab5 GTPase, a key member of the Rab family, plays a crucial role in endocytosis and membrane transport. The activated-state Rab5 recruits its effectors and regulates the internalization and trafficking of membrane receptors by regulating vesicle fusion and receptor sorting in the early endosomes. In this review, we summarize the role of small Rab GTPases Rab5 in membrane receptor trafficking and the activation of signaling pathways, such as Ras/MAPK and PI3K/Akt, which ultimately affect cell growth, apoptosis, tumorigenesis, and tumor development. This review may provide some insights for our future research and novel therapeutic targets for diseases. |
| format | Article |
| id | doaj-art-27e383d235df47cbb5267b5522a5e9e1 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-27e383d235df47cbb5267b5522a5e9e12025-02-03T01:25:49ZengWileyBiochemistry Research International2090-22472090-22552020-01-01202010.1155/2020/41863084186308The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling PathwaysWanqiong Yuan0Chunli Song1Department of Orthopedics, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 100191, ChinaDepartment of Orthopedics, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 100191, ChinaRas analog in brain (Rab) proteins are small guanosine triphosphatases (GTPases) that belong to the Ras-like GTPase superfamily, and they can regulate vesicle trafficking. Rab proteins alternate between an activated (GTP-bound) state and an inactivated (GDP-bound) state. Early endosome marker Rab5 GTPase, a key member of the Rab family, plays a crucial role in endocytosis and membrane transport. The activated-state Rab5 recruits its effectors and regulates the internalization and trafficking of membrane receptors by regulating vesicle fusion and receptor sorting in the early endosomes. In this review, we summarize the role of small Rab GTPases Rab5 in membrane receptor trafficking and the activation of signaling pathways, such as Ras/MAPK and PI3K/Akt, which ultimately affect cell growth, apoptosis, tumorigenesis, and tumor development. This review may provide some insights for our future research and novel therapeutic targets for diseases.http://dx.doi.org/10.1155/2020/4186308 |
| spellingShingle | Wanqiong Yuan Chunli Song The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways Biochemistry Research International |
| title | The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways |
| title_full | The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways |
| title_fullStr | The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways |
| title_full_unstemmed | The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways |
| title_short | The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways |
| title_sort | emerging role of rab5 in membrane receptor trafficking and signaling pathways |
| url | http://dx.doi.org/10.1155/2020/4186308 |
| work_keys_str_mv | AT wanqiongyuan theemergingroleofrab5inmembranereceptortraffickingandsignalingpathways AT chunlisong theemergingroleofrab5inmembranereceptortraffickingandsignalingpathways AT wanqiongyuan emergingroleofrab5inmembranereceptortraffickingandsignalingpathways AT chunlisong emergingroleofrab5inmembranereceptortraffickingandsignalingpathways |