Bioinspired hydrogel patch with controllable adhesion for soft tissue repair
Biomedical patches have demonstrated value in promoting soft tissue repair or anti-adhesion. Research tendency in this area focuses on developing more controllable patches to meet the complex clinical scenarios. Herein, inspired by the controllable adhesion of suction cups and the antifouling proper...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | Materials Futures |
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| Online Access: | https://doi.org/10.1088/2752-5724/adec0a |
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| author | Wenle Chen Wenzhao Li Puxiang Lai Jian Cai Lingyu Sun Yu Wang |
| author_facet | Wenle Chen Wenzhao Li Puxiang Lai Jian Cai Lingyu Sun Yu Wang |
| author_sort | Wenle Chen |
| collection | DOAJ |
| description | Biomedical patches have demonstrated value in promoting soft tissue repair or anti-adhesion. Research tendency in this area focuses on developing more controllable patches to meet the complex clinical scenarios. Herein, inspired by the controllable adhesion of suction cups and the antifouling properties of eyeball surfaces, we propose an anisotropic patch with ‘revocable’ adhesion mechanisms. For the adhesive-side, the initial adhesion forces mainly rely on suction cup’s physical interactions to allow adequate position adjustment, followed by the reaction of N-hydroxysuccinimide ester group with the tissue for firm covalent bonding. This multi-adhesive mechanism enables the spatiotemporal control of adhesive behavior. In contrast, on the barrier-side, the highly hydrated surface derived from polyethylene glycol and polyvinyl alcohol hydrogels displays no affinity for tissue proteins, thus effectively preventing tissue adhesion. Moreover, the intrinsic pores and charges enable the adsorption of positively charged inflammatory factors, while the loaded drugs can release sustainably. In vivo experiments demonstrate the patch’s strong yet controllable adhesion, effective in reducing inflammation and promoting healing. This innovative design introduces a new paradigm of ‘revocable’ adhesion, offering significant clinical potential for soft tissue repair and adhesion prevention. |
| format | Article |
| id | doaj-art-27dc31b4d7794de99b8c826b6be90b49 |
| institution | Kabale University |
| issn | 2752-5724 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Futures |
| spelling | doaj-art-27dc31b4d7794de99b8c826b6be90b492025-08-20T03:51:24ZengIOP PublishingMaterials Futures2752-57242025-01-014303500210.1088/2752-5724/adec0aBioinspired hydrogel patch with controllable adhesion for soft tissue repairWenle Chen0https://orcid.org/0000-0002-1016-7205Wenzhao Li1Puxiang Lai2Jian Cai3Lingyu Sun4https://orcid.org/0000-0003-3407-553XYu Wang5Department of Colorectal Surgery, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University , Medical Innovation Technology Transformation Center of Shenzhen Second People’s Hospital, Shenzhen University, Shenzhen, People’s Republic of China; Wenzhou Institute, University of Chinese Academy of Sciences , Wenzhou, Zhejiang 325001, People’s Republic of ChinaWenzhou Institute, University of Chinese Academy of Sciences , Wenzhou, Zhejiang 325001, People’s Republic of China; Department of Biomedical Engineering, The Hong Kong Polytechnic University , Hong Kong Special Administrative Region of China, People’s Republic of ChinaDepartment of Biomedical Engineering, The Hong Kong Polytechnic University , Hong Kong Special Administrative Region of China, People’s Republic of ChinaDepartment of Colorectal Surgery, Shenzhen Second People’s Hospital, First Affiliated Hospital of Shenzhen University , Medical Innovation Technology Transformation Center of Shenzhen Second People’s Hospital, Shenzhen University, Shenzhen, People’s Republic of ChinaDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Medical School, Nanjing University , Nanjing 210096, People’s Republic of ChinaWenzhou Institute, University of Chinese Academy of Sciences , Wenzhou, Zhejiang 325001, People’s Republic of ChinaBiomedical patches have demonstrated value in promoting soft tissue repair or anti-adhesion. Research tendency in this area focuses on developing more controllable patches to meet the complex clinical scenarios. Herein, inspired by the controllable adhesion of suction cups and the antifouling properties of eyeball surfaces, we propose an anisotropic patch with ‘revocable’ adhesion mechanisms. For the adhesive-side, the initial adhesion forces mainly rely on suction cup’s physical interactions to allow adequate position adjustment, followed by the reaction of N-hydroxysuccinimide ester group with the tissue for firm covalent bonding. This multi-adhesive mechanism enables the spatiotemporal control of adhesive behavior. In contrast, on the barrier-side, the highly hydrated surface derived from polyethylene glycol and polyvinyl alcohol hydrogels displays no affinity for tissue proteins, thus effectively preventing tissue adhesion. Moreover, the intrinsic pores and charges enable the adsorption of positively charged inflammatory factors, while the loaded drugs can release sustainably. In vivo experiments demonstrate the patch’s strong yet controllable adhesion, effective in reducing inflammation and promoting healing. This innovative design introduces a new paradigm of ‘revocable’ adhesion, offering significant clinical potential for soft tissue repair and adhesion prevention.https://doi.org/10.1088/2752-5724/adec0abio-inspiredhydrogelcontrollable adhesiontissue repairanisotropic patch |
| spellingShingle | Wenle Chen Wenzhao Li Puxiang Lai Jian Cai Lingyu Sun Yu Wang Bioinspired hydrogel patch with controllable adhesion for soft tissue repair Materials Futures bio-inspired hydrogel controllable adhesion tissue repair anisotropic patch |
| title | Bioinspired hydrogel patch with controllable adhesion for soft tissue repair |
| title_full | Bioinspired hydrogel patch with controllable adhesion for soft tissue repair |
| title_fullStr | Bioinspired hydrogel patch with controllable adhesion for soft tissue repair |
| title_full_unstemmed | Bioinspired hydrogel patch with controllable adhesion for soft tissue repair |
| title_short | Bioinspired hydrogel patch with controllable adhesion for soft tissue repair |
| title_sort | bioinspired hydrogel patch with controllable adhesion for soft tissue repair |
| topic | bio-inspired hydrogel controllable adhesion tissue repair anisotropic patch |
| url | https://doi.org/10.1088/2752-5724/adec0a |
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