Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and Catalysis
Till date, market is augmented with a huge number of improved drug delivery systems. The success in this area is basically due to biodegradable polymers. Although conventional systems of drug delivery utilizing the natural and semisynthetic polymers so long but synthetic polymer gains success in th...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2010/652719 |
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| author | Vineet Singh Meena Tiwari |
| author_facet | Vineet Singh Meena Tiwari |
| author_sort | Vineet Singh |
| collection | DOAJ |
| description | Till date, market is augmented with a huge number of improved drug delivery systems. The success in this area is basically due to biodegradable polymers. Although conventional systems of drug delivery utilizing the natural and semisynthetic polymers so long but synthetic polymer gains success in the controlled drug delivery area due to better degradation profile and controlled network and functionality. The polyesters are the most studied class group due the susceptible ester linkage in their backbone. The Poly(glycolic Acid) (PGA), Poly(lactic acid) (PLA), and Polylactide-co-glycolide (PLGA) are the best profiled polyesters and are most widely used in marketed products. These polymers, however, still are having drawbacks which failed them to be used in platform technologies like matrix systems, microspheres, and nanospheres in some cases. The common problems arose with these polymers are entrapment inefficiency, inability to degrade and release drugs with required profile, and drug instability in the microenvironment of the polymers. These problems are forcing us to develop new polymers with improved physicochemical properties. The present review gave us an insight in the various structural elements of Poly(glycolic acid), polyester, with in depth study. The first part of the review focuses on the result of studies related to synthetic methodologies and catalysts being utilized to synthesize the polyesters. However the author will also focus on the effect of processing methodologies but due some constraints those are not included in the preview of this part of review. |
| format | Article |
| id | doaj-art-27d96d6c1e6b4064b686095b56806cbe |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-27d96d6c1e6b4064b686095b56806cbe2025-02-03T01:13:11ZengWileyInternational Journal of Polymer Science1687-94221687-94302010-01-01201010.1155/2010/652719652719Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and CatalysisVineet Singh0Meena Tiwari1Polymer Laboratory, Department of Pharmacy, Shri. Govind Ram Seksaria Institute of Technology & Science, 23-Park Road, Indore 452003, IndiaPolymer Laboratory, Department of Pharmacy, Shri. Govind Ram Seksaria Institute of Technology & Science, 23-Park Road, Indore 452003, IndiaTill date, market is augmented with a huge number of improved drug delivery systems. The success in this area is basically due to biodegradable polymers. Although conventional systems of drug delivery utilizing the natural and semisynthetic polymers so long but synthetic polymer gains success in the controlled drug delivery area due to better degradation profile and controlled network and functionality. The polyesters are the most studied class group due the susceptible ester linkage in their backbone. The Poly(glycolic Acid) (PGA), Poly(lactic acid) (PLA), and Polylactide-co-glycolide (PLGA) are the best profiled polyesters and are most widely used in marketed products. These polymers, however, still are having drawbacks which failed them to be used in platform technologies like matrix systems, microspheres, and nanospheres in some cases. The common problems arose with these polymers are entrapment inefficiency, inability to degrade and release drugs with required profile, and drug instability in the microenvironment of the polymers. These problems are forcing us to develop new polymers with improved physicochemical properties. The present review gave us an insight in the various structural elements of Poly(glycolic acid), polyester, with in depth study. The first part of the review focuses on the result of studies related to synthetic methodologies and catalysts being utilized to synthesize the polyesters. However the author will also focus on the effect of processing methodologies but due some constraints those are not included in the preview of this part of review.http://dx.doi.org/10.1155/2010/652719 |
| spellingShingle | Vineet Singh Meena Tiwari Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and Catalysis International Journal of Polymer Science |
| title | Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and Catalysis |
| title_full | Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and Catalysis |
| title_fullStr | Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and Catalysis |
| title_full_unstemmed | Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and Catalysis |
| title_short | Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and Catalysis |
| title_sort | structure processing property relationship of poly glycolic acid for drug delivery systems 1 synthesis and catalysis |
| url | http://dx.doi.org/10.1155/2010/652719 |
| work_keys_str_mv | AT vineetsingh structureprocessingpropertyrelationshipofpolyglycolicacidfordrugdeliverysystems1synthesisandcatalysis AT meenatiwari structureprocessingpropertyrelationshipofpolyglycolicacidfordrugdeliverysystems1synthesisandcatalysis |