Neoadjuvant chemoradiotherapy up-regulates PD-L1 in radioresistant colorectal cancer

Neoadjuvant chemoradiotherapy up-regulates PD-L1 in radioresistant colorectal cancer

Background: Combining radiotherapy (RT) with immune checkpoint inhibitors (ICIs) is a promising strategy that can enhance the therapeutic efficacy of ICIs. However, little is known about RT-induced changes in the expression of immune checkpoints, such as PD-L1, and their clinical implications in col...

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Bibliographic Details
Main Authors: Sung Uk Bae, Hye Won Lee, Jee Young Park, Incheol Seo, Jae-Min Cho, Jin Young Kim, Ju Yup Lee, Yoo Jin Lee, Seong Kyu Baek, Nam Kyu Kim, Sang Jun Byun, Shin Kim
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Locally advanced rectal cancer
PD-L1
Chemoradiotherapy
Immune checkpoint inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630824001836
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