Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review
Ulcerative colitis (UC) is a chronic systematic inflammation disorder with increasing incidence, unknown pathogenesis, limited drug treatment, and abundant medical expenses. Dietary intake, as a daily indispensable environment factor, is closely related to UC pathogenesis and prevention. The underly...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2021-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000252 |
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| author | Wen Zeng Dong He Yifan Xing Junyu Liu Nan Su Chong Zhang Yi Wang Xinhui Xing |
| author_facet | Wen Zeng Dong He Yifan Xing Junyu Liu Nan Su Chong Zhang Yi Wang Xinhui Xing |
| author_sort | Wen Zeng |
| collection | DOAJ |
| description | Ulcerative colitis (UC) is a chronic systematic inflammation disorder with increasing incidence, unknown pathogenesis, limited drug treatment, and abundant medical expenses. Dietary intake, as a daily indispensable environment factor, is closely related to UC pathogenesis and prevention. The underlying interactions between dietary intake and UC progression are implicated with the modulation of gut microbiome as well as microbial metabolites, suggesting the complex and systematic characteristics of UC. However, the triangular relationships with dietary intake, gut microbiota homeostasis, and UC have not been well summarized so far. Here we review the recent studies of dietary intake on the regulation of gut microbiome homeostasis as well as modulation of UC progression. These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites, which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation, inflammation restriction as well as epithelial barrier maintenance, thus finally determine the fate of UC progression and give implications for functional food development for prevention and treatment of UC patients. |
| format | Article |
| id | doaj-art-27af7ab986684ef387b1989922edd668 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-27af7ab986684ef387b1989922edd6682025-02-03T02:33:49ZengTsinghua University PressFood Science and Human Wellness2213-45302021-03-01102119130Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a reviewWen Zeng0Dong He1Yifan Xing2Junyu Liu3Nan Su4Chong Zhang5Yi Wang6Xinhui Xing7MOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; Centre for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, ChinaMOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; Corresponding author. Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, China.MOE Key Laboratory for Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; Centre for Synthetic and Systems Biology, Tsinghua University, Beijing 100084, China; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China; Corresponding author. Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, China.Ulcerative colitis (UC) is a chronic systematic inflammation disorder with increasing incidence, unknown pathogenesis, limited drug treatment, and abundant medical expenses. Dietary intake, as a daily indispensable environment factor, is closely related to UC pathogenesis and prevention. The underlying interactions between dietary intake and UC progression are implicated with the modulation of gut microbiome as well as microbial metabolites, suggesting the complex and systematic characteristics of UC. However, the triangular relationships with dietary intake, gut microbiota homeostasis, and UC have not been well summarized so far. Here we review the recent studies of dietary intake on the regulation of gut microbiome homeostasis as well as modulation of UC progression. These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites, which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation, inflammation restriction as well as epithelial barrier maintenance, thus finally determine the fate of UC progression and give implications for functional food development for prevention and treatment of UC patients.http://www.sciencedirect.com/science/article/pii/S2213453021000252Ulcerative colitisDietary intakeGut microbiomeMetaboliteHomeostasis |
| spellingShingle | Wen Zeng Dong He Yifan Xing Junyu Liu Nan Su Chong Zhang Yi Wang Xinhui Xing Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review Food Science and Human Wellness Ulcerative colitis Dietary intake Gut microbiome Metabolite Homeostasis |
| title | Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review |
| title_full | Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review |
| title_fullStr | Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review |
| title_full_unstemmed | Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review |
| title_short | Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review |
| title_sort | internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis a review |
| topic | Ulcerative colitis Dietary intake Gut microbiome Metabolite Homeostasis |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000252 |
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