Temporomandibular joint disorder related to cancer metastasis: A review on reported cases in the literature
Abstract Introduction Metastasis to the temporomandibular joint is an uncommon clinical entity that often mimics benign temporomandibular disorders, leading to diagnostic challenges. This systematic review aimed to consolidate the existing literature on temporomandibular joint metastasis to delineat...
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| Format: | Article |
| Language: | English |
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Springer
2025-08-01
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| Series: | Saudi Dental Journal |
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| Online Access: | https://doi.org/10.1007/s44445-025-00043-w |
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| author | Hamed Mortazavi Anita Taheri Sara Alehossein Mehdi Hashemi |
| author_facet | Hamed Mortazavi Anita Taheri Sara Alehossein Mehdi Hashemi |
| author_sort | Hamed Mortazavi |
| collection | DOAJ |
| description | Abstract Introduction Metastasis to the temporomandibular joint is an uncommon clinical entity that often mimics benign temporomandibular disorders, leading to diagnostic challenges. This systematic review aimed to consolidate the existing literature on temporomandibular joint metastasis to delineate its clinical and demographic characteristics, diagnostic pitfalls, and treatment approaches. Methods A comprehensive search was conducted across PubMed/MEDLINE, Scopus, and Embase electronic databases. Two independent reviewers screened the titles, abstracts, and full texts of 3,659 articles, ultimately selecting 47 articles encompassing 55 reported cases. Results The analysis revealed a mean patient age of 61.8 ± 13.99 years, with a slight female predominance. Lung and breast cancers were the most common primary sites, with adenocarcinoma being the predominant histopathological type. Clinically, pain, swelling, and restricted mouth opening were the most frequently observed symptoms, although a subset of patients presented with atypical features. Notably, in 49% of cases, TMJ metastasis was detected prior to the diagnosis of the primary malignancy. Multimodal treatment, incorporating combinations of chemotherapy, radiotherapy, and surgery, was the most common therapeutic approach. |
| format | Article |
| id | doaj-art-27aa7ebd1825483e9b4cc1f65adf7a95 |
| institution | Kabale University |
| issn | 1013-9052 2524-1702 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-27aa7ebd1825483e9b4cc1f65adf7a952025-08-20T03:46:20ZengSpringerSaudi Dental Journal1013-90522524-17022025-08-01377-911610.1007/s44445-025-00043-wTemporomandibular joint disorder related to cancer metastasis: A review on reported cases in the literatureHamed Mortazavi0Anita Taheri1Sara Alehossein2Mehdi Hashemi3Department of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical SciencesSina Trauma and Surgery Research Center, Tehran University of Medical SciencesSchool of Dentistry, Shahid Beheshti University of Medical SciencesDental Research Center, Mazandaran University of Medical SciencesAbstract Introduction Metastasis to the temporomandibular joint is an uncommon clinical entity that often mimics benign temporomandibular disorders, leading to diagnostic challenges. This systematic review aimed to consolidate the existing literature on temporomandibular joint metastasis to delineate its clinical and demographic characteristics, diagnostic pitfalls, and treatment approaches. Methods A comprehensive search was conducted across PubMed/MEDLINE, Scopus, and Embase electronic databases. Two independent reviewers screened the titles, abstracts, and full texts of 3,659 articles, ultimately selecting 47 articles encompassing 55 reported cases. Results The analysis revealed a mean patient age of 61.8 ± 13.99 years, with a slight female predominance. Lung and breast cancers were the most common primary sites, with adenocarcinoma being the predominant histopathological type. Clinically, pain, swelling, and restricted mouth opening were the most frequently observed symptoms, although a subset of patients presented with atypical features. Notably, in 49% of cases, TMJ metastasis was detected prior to the diagnosis of the primary malignancy. Multimodal treatment, incorporating combinations of chemotherapy, radiotherapy, and surgery, was the most common therapeutic approach.https://doi.org/10.1007/s44445-025-00043-wCancerMetastasisTemporomandibular JointAdenocarcinoma |
| spellingShingle | Hamed Mortazavi Anita Taheri Sara Alehossein Mehdi Hashemi Temporomandibular joint disorder related to cancer metastasis: A review on reported cases in the literature Saudi Dental Journal Cancer Metastasis Temporomandibular Joint Adenocarcinoma |
| title | Temporomandibular joint disorder related to cancer metastasis: A review on reported cases in the literature |
| title_full | Temporomandibular joint disorder related to cancer metastasis: A review on reported cases in the literature |
| title_fullStr | Temporomandibular joint disorder related to cancer metastasis: A review on reported cases in the literature |
| title_full_unstemmed | Temporomandibular joint disorder related to cancer metastasis: A review on reported cases in the literature |
| title_short | Temporomandibular joint disorder related to cancer metastasis: A review on reported cases in the literature |
| title_sort | temporomandibular joint disorder related to cancer metastasis a review on reported cases in the literature |
| topic | Cancer Metastasis Temporomandibular Joint Adenocarcinoma |
| url | https://doi.org/10.1007/s44445-025-00043-w |
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