STRUCTURAL ABERRATIONS OF 1p36 IN HEMATOLOGIC MALIGNANCIES
Objective: Structural aberrations of 1p36 are very common in most hematologic malignancies. 1p36 consists of genes that are important in oncogenesis. The aim of this study was to define 1p36 abnormalities and their distributions within different hematologic malignancies.Materials and Methods: To ach...
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Istanbul University Press
2023-10-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/CA1AFA39D77946539DF72ADD4C09992A |
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| _version_ | 1849313416334802944 |
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| author | Rahiye Dilhan Kuru Ayşe Çırakoğlu Şükriye Yılmaz Şeniz Öngören Muhlis Cem Ar Teoman Soysal Ayhan Deviren Yelda Tarkan Argüden |
| author_facet | Rahiye Dilhan Kuru Ayşe Çırakoğlu Şükriye Yılmaz Şeniz Öngören Muhlis Cem Ar Teoman Soysal Ayhan Deviren Yelda Tarkan Argüden |
| author_sort | Rahiye Dilhan Kuru |
| collection | DOAJ |
| description | Objective: Structural aberrations of 1p36 are very common in most hematologic malignancies. 1p36 consists of genes that are important in oncogenesis. The aim of this study was to define 1p36 abnormalities and their distributions within different hematologic malignancies.Materials and Methods: To achieve this goal, we retrospectively evaluated the cytogenetic results of our hematological cancer cases.Result: We found deletions or rearrangements of breakpoint 1p36 in 18 patients with various hematologic malignancies, including myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), multiple myeloma (MM), chronic myeloid leukemia (CML), lymphoma, B cell acute lymphoblastic leukemia (B-ALL), idiopathic thrombocytopenic purpura (ITP) and aplastic anemia (AA). We observed t(1;3)(p36;p21) in one AML-M2 patient and t(1;3)(p36;q21) in two CML patients. Eight patients (1 MDS, 2 MM, 3 CML, 1 AML, and 1 AA) had translocations and rearrangements. One ITP patient had der(1)t(1;1)(p36;q21) and another CML patient had der(1)t(1;1)(p36;q12). We demonstrated several terminal deletions with different breakpoints between 1p11 and 1p36 in five patients, (2 MDS, 2 lymphomas, and 1 B cell acute lymphocytic leukemia).Conclusion: The 1p36 breakpoint is a hot spot for cancer-related chromosome rearrangements and is associated with poor prognosis. In order to emphasize the importance of 1p36 in hematologic malignancies it essential to build a large data pool on the subject. The distribution of breakpoints in 1p abnormalities in our series was remarkable, as 12 out of 18 1p breakpoints were 1p36. However, while 1p breakpoints aggregated on 1p36 in all translocations, there was only one 1p36 breakpoint in five deletions. With this paper, we contribute to the relevant literature by reporting our results. |
| format | Article |
| id | doaj-art-279102b7f4654e46a7bdb1454c87d9df |
| institution | Kabale University |
| issn | 1305-6441 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-279102b7f4654e46a7bdb1454c87d9df2025-08-20T03:52:47ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412023-10-0186433634410.26650/IUITFD.1317330123456STRUCTURAL ABERRATIONS OF 1p36 IN HEMATOLOGIC MALIGNANCIESRahiye Dilhan Kuru0https://orcid.org/0000-0001-8088-5336Ayşe Çırakoğlu1https://orcid.org/0000-0003-0330-2277Şükriye Yılmaz2https://orcid.org/0000-0001-8076-3080Şeniz Öngören3https://orcid.org/0000-0002-2809-5510Muhlis Cem Ar4https://orcid.org/0000-0002-0332-9253Teoman Soysal5https://orcid.org/0000-0002-7417-2118Ayhan Deviren6https://orcid.org/0000-0003-2117-8230Yelda Tarkan Argüden7https://orcid.org/0000-0002-5405-3365İstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, Turkiyeİstanbul Üniversitesi-Cerrahpaşa, Istanbul, TurkiyeObjective: Structural aberrations of 1p36 are very common in most hematologic malignancies. 1p36 consists of genes that are important in oncogenesis. The aim of this study was to define 1p36 abnormalities and their distributions within different hematologic malignancies.Materials and Methods: To achieve this goal, we retrospectively evaluated the cytogenetic results of our hematological cancer cases.Result: We found deletions or rearrangements of breakpoint 1p36 in 18 patients with various hematologic malignancies, including myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), multiple myeloma (MM), chronic myeloid leukemia (CML), lymphoma, B cell acute lymphoblastic leukemia (B-ALL), idiopathic thrombocytopenic purpura (ITP) and aplastic anemia (AA). We observed t(1;3)(p36;p21) in one AML-M2 patient and t(1;3)(p36;q21) in two CML patients. Eight patients (1 MDS, 2 MM, 3 CML, 1 AML, and 1 AA) had translocations and rearrangements. One ITP patient had der(1)t(1;1)(p36;q21) and another CML patient had der(1)t(1;1)(p36;q12). We demonstrated several terminal deletions with different breakpoints between 1p11 and 1p36 in five patients, (2 MDS, 2 lymphomas, and 1 B cell acute lymphocytic leukemia).Conclusion: The 1p36 breakpoint is a hot spot for cancer-related chromosome rearrangements and is associated with poor prognosis. In order to emphasize the importance of 1p36 in hematologic malignancies it essential to build a large data pool on the subject. The distribution of breakpoints in 1p abnormalities in our series was remarkable, as 12 out of 18 1p breakpoints were 1p36. However, while 1p breakpoints aggregated on 1p36 in all translocations, there was only one 1p36 breakpoint in five deletions. With this paper, we contribute to the relevant literature by reporting our results.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/CA1AFA39D77946539DF72ADD4C09992A1p36leukemialymphoid malignanciesmyeloid malignanciescytogeneticsbone marrow |
| spellingShingle | Rahiye Dilhan Kuru Ayşe Çırakoğlu Şükriye Yılmaz Şeniz Öngören Muhlis Cem Ar Teoman Soysal Ayhan Deviren Yelda Tarkan Argüden STRUCTURAL ABERRATIONS OF 1p36 IN HEMATOLOGIC MALIGNANCIES İstanbul Tıp Fakültesi Dergisi 1p36 leukemia lymphoid malignancies myeloid malignancies cytogenetics bone marrow |
| title | STRUCTURAL ABERRATIONS OF 1p36 IN HEMATOLOGIC MALIGNANCIES |
| title_full | STRUCTURAL ABERRATIONS OF 1p36 IN HEMATOLOGIC MALIGNANCIES |
| title_fullStr | STRUCTURAL ABERRATIONS OF 1p36 IN HEMATOLOGIC MALIGNANCIES |
| title_full_unstemmed | STRUCTURAL ABERRATIONS OF 1p36 IN HEMATOLOGIC MALIGNANCIES |
| title_short | STRUCTURAL ABERRATIONS OF 1p36 IN HEMATOLOGIC MALIGNANCIES |
| title_sort | structural aberrations of 1p36 in hematologic malignancies |
| topic | 1p36 leukemia lymphoid malignancies myeloid malignancies cytogenetics bone marrow |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/CA1AFA39D77946539DF72ADD4C09992A |
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