Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study
Background Acute kidney injury (AKI) is recognized as a common complication following cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Characterized by prolonged renal function impairment, acute kidney disease (AKD) is associated with a higher risk of chroni...
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| Format: | Article |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338482 |
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| author | Yunwei Lu Ziyan Xiao Xiujuan Zhao Yingjiang Ye Shu Li Fuzheng Guo Haiyan Xue Fengxue Zhu |
| author_facet | Yunwei Lu Ziyan Xiao Xiujuan Zhao Yingjiang Ye Shu Li Fuzheng Guo Haiyan Xue Fengxue Zhu |
| author_sort | Yunwei Lu |
| collection | DOAJ |
| description | Background Acute kidney injury (AKI) is recognized as a common complication following cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Characterized by prolonged renal function impairment, acute kidney disease (AKD) is associated with a higher risk of chronic kidney disease (CKD) and mortality.Methods From January 2018 to December 2021, 158 patients undergoing CRS-HIPEC were retrospectively reviewed. Patients were separated into non-AKI, AKI, and AKD cohorts. Laboratory parameters and perioperative features were gathered to evaluate risk factors for both HIPEC-induced AKI and AKD, with the 90-day prognosis of AKD patients.Results AKI developed in 21.5% of patients undergoing CRS-HIPEC, while 13.3% progressed to AKD. The multivariate analysis identified that ascites, GRAN%, estimated glomerular filtration rate (eGFR), and intraoperative (IO) hypotension duration were associated with the development of HIPEC-induced AKI. Higher uric acid, lessened eGFR, and prolonged IO hypotension duration were more predominant in patients proceeding with AKD. The AKD cohort presented a higher risk of 30 days of in-hospital mortality (14.3%) and CKD progression (42.8%).Conclusions Our study reveals a high incidence of AKI and AKI-to-AKD transition. Early identification of risk factors for HIPEC-induced AKD would assist clinicians in taking measures to mitigate the incidence. |
| format | Article |
| id | doaj-art-277ea9b3e2f143f9b5161faaff09c6e0 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-277ea9b3e2f143f9b5161faaff09c6e02025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2338482Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective studyYunwei Lu0Ziyan Xiao1Xiujuan Zhao2Yingjiang Ye3Shu Li4Fuzheng Guo5Haiyan Xue6Fengxue Zhu7Department of Intensive Care Medicine, Trauma Center, Peking University People’s Hospital, Beijing, ChinaDepartment of Intensive Care Medicine, Trauma Center, Peking University People’s Hospital, Beijing, ChinaDepartment of Intensive Care Medicine, Trauma Center, Peking University People’s Hospital, Beijing, ChinaDepartment of Gastrointestinal Surgery, Peking University People’s Hospital, Beijing, ChinaDepartment of Intensive Care Medicine, Trauma Center, Peking University People’s Hospital, Beijing, ChinaDepartment of Intensive Care Medicine, Trauma Center, Peking University People’s Hospital, Beijing, ChinaDepartment of Intensive Care Medicine, Trauma Center, Peking University People’s Hospital, Beijing, ChinaDepartment of Intensive Care Medicine, Trauma Center, Peking University People’s Hospital, Beijing, ChinaBackground Acute kidney injury (AKI) is recognized as a common complication following cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Characterized by prolonged renal function impairment, acute kidney disease (AKD) is associated with a higher risk of chronic kidney disease (CKD) and mortality.Methods From January 2018 to December 2021, 158 patients undergoing CRS-HIPEC were retrospectively reviewed. Patients were separated into non-AKI, AKI, and AKD cohorts. Laboratory parameters and perioperative features were gathered to evaluate risk factors for both HIPEC-induced AKI and AKD, with the 90-day prognosis of AKD patients.Results AKI developed in 21.5% of patients undergoing CRS-HIPEC, while 13.3% progressed to AKD. The multivariate analysis identified that ascites, GRAN%, estimated glomerular filtration rate (eGFR), and intraoperative (IO) hypotension duration were associated with the development of HIPEC-induced AKI. Higher uric acid, lessened eGFR, and prolonged IO hypotension duration were more predominant in patients proceeding with AKD. The AKD cohort presented a higher risk of 30 days of in-hospital mortality (14.3%) and CKD progression (42.8%).Conclusions Our study reveals a high incidence of AKI and AKI-to-AKD transition. Early identification of risk factors for HIPEC-induced AKD would assist clinicians in taking measures to mitigate the incidence.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338482HIPECAKIAKDCKDrenal function |
| spellingShingle | Yunwei Lu Ziyan Xiao Xiujuan Zhao Yingjiang Ye Shu Li Fuzheng Guo Haiyan Xue Fengxue Zhu Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study Renal Failure HIPEC AKI AKD CKD renal function |
| title | Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study |
| title_full | Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study |
| title_fullStr | Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study |
| title_full_unstemmed | Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study |
| title_short | Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: a retrospective study |
| title_sort | incidence risk factors and outcomes of the transition of hipec induced acute kidney injury to acute kidney disease a retrospective study |
| topic | HIPEC AKI AKD CKD renal function |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338482 |
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