Improving the N-glycosylation occupancy of plant-produced IgG1 by engineering the amino acid environment at Asn297

Improving the N-glycosylation occupancy of plant-produced IgG1 by engineering the amino acid environment at Asn297

Monoclonal antibodies are crucial recombinant biopharmaceuticals, with N-glycosylation at Asn297 essential for their functionality. Plants are increasingly used for antibody production, achieving high expression levels and enabling glycoengineering to produce homogenous human-like N-glycan structure...

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Bibliographic Details
Main Authors: Kathrin Göritzer, Valentina Ruocco, Ulrike Vavra, Shiva Izadi, Omayra C. Bolaños-Martínez, Thareeya Phetphoung, Nuttapat Pisuttinusart, Waranyoo Phoolcharoen, Richard Strasser
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Plant Science
Subjects:
monoclonal antibodies
Nicotiana benthamiana
IgG1
N-glycosylation
glycosylation efficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fpls.2024.1531710/full
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