Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion
Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration of plasma cells into the endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women’...
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2025-01-01
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| author | Francesco Di Gennaro Giacomo Guido Luisa Frallonardo Laura Pennazzi Miriana Bevilacqua Pietro Locantore Amerigo Vitagliano Annalisa Saracino Ettore Cicinelli |
| author_facet | Francesco Di Gennaro Giacomo Guido Luisa Frallonardo Laura Pennazzi Miriana Bevilacqua Pietro Locantore Amerigo Vitagliano Annalisa Saracino Ettore Cicinelli |
| author_sort | Francesco Di Gennaro |
| collection | DOAJ |
| description | Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration of plasma cells into the endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women’s health, contributing to conditions such as abnormal uterine bleeding and endometriosis. Treatment typically involves antibiotic therapy; however, the efficacy of these treatments is increasingly compromised by the rise of antimicrobial resistance (AMR). This paper examines the critical links between AMR and CE, proposing strategies to enhance clinical management and optimize treatment outcomes. |
| format | Article |
| id | doaj-art-2776f3ab6daa44b596802220919f156e |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-2776f3ab6daa44b596802220919f156e2025-01-24T13:43:01ZengMDPI AGMicroorganisms2076-26072025-01-0113119710.3390/microorganisms13010197Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert OpinionFrancesco Di Gennaro0Giacomo Guido1Luisa Frallonardo2Laura Pennazzi3Miriana Bevilacqua4Pietro Locantore5Amerigo Vitagliano6Annalisa Saracino7Ettore Cicinelli8Clinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, Piazza Giulio Cesare n. 11, Cap 70124 Bari, ItalyClinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, Piazza Giulio Cesare n. 11, Cap 70124 Bari, ItalyClinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, Piazza Giulio Cesare n. 11, Cap 70124 Bari, ItalyStudio Ostetrico/Nutrizionale DeaLuce, Cap 00168 Rome, ItalyClinic of Obstetrics & Gynaecology, University of “Aldo Moro”, Cap 70124 Bari, ItalyUnit of Endocrinology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Fondazione Policlinico “A. Gemelli” IRCCS, Cap 00168 Rome, ItalyClinic of Obstetrics & Gynaecology, University of “Aldo Moro”, Cap 70124 Bari, ItalyClinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”, Piazza Giulio Cesare n. 11, Cap 70124 Bari, ItalyClinic of Obstetrics & Gynaecology, University of “Aldo Moro”, Cap 70124 Bari, ItalyChronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration of plasma cells into the endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women’s health, contributing to conditions such as abnormal uterine bleeding and endometriosis. Treatment typically involves antibiotic therapy; however, the efficacy of these treatments is increasingly compromised by the rise of antimicrobial resistance (AMR). This paper examines the critical links between AMR and CE, proposing strategies to enhance clinical management and optimize treatment outcomes.https://www.mdpi.com/2076-2607/13/1/197antibiotic treatmentchronic endometritisfertilitymultidrug resistancepersistent chronic endometritis |
| spellingShingle | Francesco Di Gennaro Giacomo Guido Luisa Frallonardo Laura Pennazzi Miriana Bevilacqua Pietro Locantore Amerigo Vitagliano Annalisa Saracino Ettore Cicinelli Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion Microorganisms antibiotic treatment chronic endometritis fertility multidrug resistance persistent chronic endometritis |
| title | Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion |
| title_full | Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion |
| title_fullStr | Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion |
| title_full_unstemmed | Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion |
| title_short | Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion |
| title_sort | chronic endometritis and antimicrobial resistance towards a multidrug resistant endometritis an expert opinion |
| topic | antibiotic treatment chronic endometritis fertility multidrug resistance persistent chronic endometritis |
| url | https://www.mdpi.com/2076-2607/13/1/197 |
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