Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets
One titrimetric and two spectrophotometric methods which are simple, sensitive, and economic are described for the determination of sumatriptan succinate (STS) in bulk drug and in tablet dosage form using N-bromosuccinimide (NBS) as a brominating agent. In titrimetry, aqueous solution of STS is trea...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/934357 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563970254307328 |
|---|---|
| author | Kudige N. Prashanth Kanakapura Basavaiah Madihalli S. Raghu |
| author_facet | Kudige N. Prashanth Kanakapura Basavaiah Madihalli S. Raghu |
| author_sort | Kudige N. Prashanth |
| collection | DOAJ |
| description | One titrimetric and two spectrophotometric methods which are simple, sensitive, and economic are described for the determination of sumatriptan succinate (STS) in bulk drug and in tablet dosage form using N-bromosuccinimide (NBS) as a brominating agent. In titrimetry, aqueous solution of STS is treated with a measured excess of NBS in acetic acid medium, and after the bromination of STS is judged to be complete, the unreacted NBS is determined iodometrically (method A). Spectrophotometric methods entail addition of a known excess of NBS in acid medium followed by the determination of residual NBS by its reaction with excess iodide, and the liberated iodine () is either measured at 370 nm (method B) or liberated iodine is reacted with starch followed by the measurement of the blue colored starch-iodine complex at 570 nm (method C). Titrimetric method is applicable over range 1.0–10.0 mg STS (method A), and the reaction stoichiometry is found to be 1 : 3 (STS : NBS). The spectrophotometric methods obey Beer’s law for concentration range 0.6–15.0 μg mL−1 (method B) and 0.2–4.0 μg mL−1 (method C). The calculated apparent molar absorptivity values were found to be 2.10 × 104 and 7.44 × 104 L mol−1 cm−1, for method B and method C, respectively. |
| format | Article |
| id | doaj-art-276279d49cc34192827067aa324a6674 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-276279d49cc34192827067aa324a66742025-02-03T01:12:10ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792013-01-01201310.1155/2013/934357934357Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and TabletsKudige N. Prashanth0Kanakapura Basavaiah1Madihalli S. Raghu2Department of Chemistry, University of Mysore, Manasagangotri, Mysore, Karnataka 570006, IndiaDepartment of Chemistry, University of Mysore, Manasagangotri, Mysore, Karnataka 570006, IndiaDepartment of Chemistry, University of Mysore, Manasagangotri, Mysore, Karnataka 570006, IndiaOne titrimetric and two spectrophotometric methods which are simple, sensitive, and economic are described for the determination of sumatriptan succinate (STS) in bulk drug and in tablet dosage form using N-bromosuccinimide (NBS) as a brominating agent. In titrimetry, aqueous solution of STS is treated with a measured excess of NBS in acetic acid medium, and after the bromination of STS is judged to be complete, the unreacted NBS is determined iodometrically (method A). Spectrophotometric methods entail addition of a known excess of NBS in acid medium followed by the determination of residual NBS by its reaction with excess iodide, and the liberated iodine () is either measured at 370 nm (method B) or liberated iodine is reacted with starch followed by the measurement of the blue colored starch-iodine complex at 570 nm (method C). Titrimetric method is applicable over range 1.0–10.0 mg STS (method A), and the reaction stoichiometry is found to be 1 : 3 (STS : NBS). The spectrophotometric methods obey Beer’s law for concentration range 0.6–15.0 μg mL−1 (method B) and 0.2–4.0 μg mL−1 (method C). The calculated apparent molar absorptivity values were found to be 2.10 × 104 and 7.44 × 104 L mol−1 cm−1, for method B and method C, respectively.http://dx.doi.org/10.1155/2013/934357 |
| spellingShingle | Kudige N. Prashanth Kanakapura Basavaiah Madihalli S. Raghu Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets International Journal of Analytical Chemistry |
| title | Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets |
| title_full | Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets |
| title_fullStr | Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets |
| title_full_unstemmed | Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets |
| title_short | Utilization of N-Bromosuccinimide as a Brominating Agent for the Determination of Sumatriptan Succinate in Bulk Drug and Tablets |
| title_sort | utilization of n bromosuccinimide as a brominating agent for the determination of sumatriptan succinate in bulk drug and tablets |
| url | http://dx.doi.org/10.1155/2013/934357 |
| work_keys_str_mv | AT kudigenprashanth utilizationofnbromosuccinimideasabrominatingagentforthedeterminationofsumatriptansuccinateinbulkdrugandtablets AT kanakapurabasavaiah utilizationofnbromosuccinimideasabrominatingagentforthedeterminationofsumatriptansuccinateinbulkdrugandtablets AT madihallisraghu utilizationofnbromosuccinimideasabrominatingagentforthedeterminationofsumatriptansuccinateinbulkdrugandtablets |