A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a most powerful immunotherapy for hematological malignancies. However, the impact of immunological disturbances as a result of allo-HSCT is not understood well. We experienced an 11-year-old boy who presented with systemic lupus eryth...
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Wiley
2012-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/619126 |
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| author | Masayuki Nagasawa Yuki Aoki |
| author_facet | Masayuki Nagasawa Yuki Aoki |
| author_sort | Masayuki Nagasawa |
| collection | DOAJ |
| description | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a most powerful immunotherapy for hematological malignancies. However, the impact of immunological disturbances as a result of allo-HSCT is not understood well. We experienced an 11-year-old boy who presented with systemic lupus erythemathosus (SLE) 10 years after unrelated cord blood transplantation of male origin for juvenile myelomonocytic leukemia (JMML) with monosomy 7. Bone marrow examination showed complete remission without monosomy 7. Genetic analysis of peripheral blood revealed mixed chimera with recipient cells consisting of <5% of T cells, 50–60% of B cells, 60–75% of NK cells, 70–80% of macrophages, and 50–60% of granulocytes. Significance of persistent mixed chimera as a cause of SLE is discussed. |
| format | Article |
| id | doaj-art-27609b23564f4532b93f174e366653ae |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-27609b23564f4532b93f174e366653ae2025-02-03T06:12:17ZengWileyCase Reports in Transplantation2090-69432090-69512012-01-01201210.1155/2012/619126619126A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic LeukemiaMasayuki Nagasawa0Yuki Aoki1Department of Developmental Biology, Post Graduate School, Tokyo Medical and Dental University, 5–45, Yushima 1-chome, Bunkyo-ku, Tokyo 113-8519, JapanDepartment of Developmental Biology, Post Graduate School, Tokyo Medical and Dental University, 5–45, Yushima 1-chome, Bunkyo-ku, Tokyo 113-8519, JapanAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is a most powerful immunotherapy for hematological malignancies. However, the impact of immunological disturbances as a result of allo-HSCT is not understood well. We experienced an 11-year-old boy who presented with systemic lupus erythemathosus (SLE) 10 years after unrelated cord blood transplantation of male origin for juvenile myelomonocytic leukemia (JMML) with monosomy 7. Bone marrow examination showed complete remission without monosomy 7. Genetic analysis of peripheral blood revealed mixed chimera with recipient cells consisting of <5% of T cells, 50–60% of B cells, 60–75% of NK cells, 70–80% of macrophages, and 50–60% of granulocytes. Significance of persistent mixed chimera as a cause of SLE is discussed.http://dx.doi.org/10.1155/2012/619126 |
| spellingShingle | Masayuki Nagasawa Yuki Aoki A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia Case Reports in Transplantation |
| title | A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia |
| title_full | A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia |
| title_fullStr | A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia |
| title_full_unstemmed | A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia |
| title_short | A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia |
| title_sort | pediatric case of systemic lupus erythematosus developed 10 years after cord blood transplantation for juvenile myelomonocytic leukemia |
| url | http://dx.doi.org/10.1155/2012/619126 |
| work_keys_str_mv | AT masayukinagasawa apediatriccaseofsystemiclupuserythematosusdeveloped10yearsaftercordbloodtransplantationforjuvenilemyelomonocyticleukemia AT yukiaoki apediatriccaseofsystemiclupuserythematosusdeveloped10yearsaftercordbloodtransplantationforjuvenilemyelomonocyticleukemia AT masayukinagasawa pediatriccaseofsystemiclupuserythematosusdeveloped10yearsaftercordbloodtransplantationforjuvenilemyelomonocyticleukemia AT yukiaoki pediatriccaseofsystemiclupuserythematosusdeveloped10yearsaftercordbloodtransplantationforjuvenilemyelomonocyticleukemia |