Mitochondrial Dynamics: Functional Link with Apoptosis
Mitochondria participate in a variety of physiologic processes, such as ATP production, lipid metabolism, iron-sulfur cluster biogenesis, and calcium buffering. The morphology of mitochondria changes dynamically due to their frequent fusion and division in response to cellular conditions, and these...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/821676 |
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| _version_ | 1832553594905165824 |
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| author | Hidenori Otera Katsuyoshi Mihara |
| author_facet | Hidenori Otera Katsuyoshi Mihara |
| author_sort | Hidenori Otera |
| collection | DOAJ |
| description | Mitochondria participate in a variety of physiologic processes, such as ATP production, lipid metabolism, iron-sulfur cluster biogenesis, and calcium buffering. The morphology of mitochondria changes dynamically due to their frequent fusion and division in response to cellular conditions, and these dynamics are an important constituent of apoptosis. The discovery of large GTPase family proteins that regulate mitochondrial dynamics, together with novel insights into the role of mitochondrial fusion and fission in apoptosis, has provided important clues to understanding the molecular mechanisms of cellular apoptosis. In this paper, we briefly summarize current knowledge of the role of mitochondrial dynamics in apoptosis and cell pathophysiology in mammalian cells. |
| format | Article |
| id | doaj-art-275f765031a9454ba7ceddf68b0f929a |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-275f765031a9454ba7ceddf68b0f929a2025-02-03T05:53:36ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/821676821676Mitochondrial Dynamics: Functional Link with ApoptosisHidenori Otera0Katsuyoshi Mihara1Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, JapanDepartment of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, JapanMitochondria participate in a variety of physiologic processes, such as ATP production, lipid metabolism, iron-sulfur cluster biogenesis, and calcium buffering. The morphology of mitochondria changes dynamically due to their frequent fusion and division in response to cellular conditions, and these dynamics are an important constituent of apoptosis. The discovery of large GTPase family proteins that regulate mitochondrial dynamics, together with novel insights into the role of mitochondrial fusion and fission in apoptosis, has provided important clues to understanding the molecular mechanisms of cellular apoptosis. In this paper, we briefly summarize current knowledge of the role of mitochondrial dynamics in apoptosis and cell pathophysiology in mammalian cells.http://dx.doi.org/10.1155/2012/821676 |
| spellingShingle | Hidenori Otera Katsuyoshi Mihara Mitochondrial Dynamics: Functional Link with Apoptosis International Journal of Cell Biology |
| title | Mitochondrial Dynamics: Functional Link with Apoptosis |
| title_full | Mitochondrial Dynamics: Functional Link with Apoptosis |
| title_fullStr | Mitochondrial Dynamics: Functional Link with Apoptosis |
| title_full_unstemmed | Mitochondrial Dynamics: Functional Link with Apoptosis |
| title_short | Mitochondrial Dynamics: Functional Link with Apoptosis |
| title_sort | mitochondrial dynamics functional link with apoptosis |
| url | http://dx.doi.org/10.1155/2012/821676 |
| work_keys_str_mv | AT hidenoriotera mitochondrialdynamicsfunctionallinkwithapoptosis AT katsuyoshimihara mitochondrialdynamicsfunctionallinkwithapoptosis |