Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light
This work utilizes tailored – Cu2O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of Klebsiella pneumoniae, and 98.92 % of SARS-CoV Delta...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | Case Studies in Chemical and Environmental Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666016425001550 |
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| author | Azzah Dyah Pramata Farhan Aryo Hutomo Febriyansyah Saputra Paundra Rizky Pratama Taras Geonovive De Yenarosa Sutarsis Sigit Tri Wicaksono Agung Purniawan Revianny Nidom Shao-Yang Hu |
| author_facet | Azzah Dyah Pramata Farhan Aryo Hutomo Febriyansyah Saputra Paundra Rizky Pratama Taras Geonovive De Yenarosa Sutarsis Sigit Tri Wicaksono Agung Purniawan Revianny Nidom Shao-Yang Hu |
| author_sort | Azzah Dyah Pramata |
| collection | DOAJ |
| description | This work utilizes tailored – Cu2O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of Klebsiella pneumoniae, and 98.92 % of SARS-CoV Delta within 1 min under visible light. Cu2O QDs efficiently reduced 99.25 % viability of 4T1 cancer cells in 15 min while maintaining more than 85 % viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu2O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications. |
| format | Article |
| id | doaj-art-273e2d0271cf435f89dc8ddb9bf8e6d7 |
| institution | DOAJ |
| issn | 2666-0164 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Studies in Chemical and Environmental Engineering |
| spelling | doaj-art-273e2d0271cf435f89dc8ddb9bf8e6d72025-08-20T03:11:14ZengElsevierCase Studies in Chemical and Environmental Engineering2666-01642025-12-011210124810.1016/j.cscee.2025.101248Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible lightAzzah Dyah Pramata0Farhan Aryo Hutomo1Febriyansyah Saputra2Paundra Rizky Pratama3Taras Geonovive De Yenarosa4 Sutarsis5Sigit Tri Wicaksono6Agung Purniawan7Revianny Nidom8Shao-Yang Hu9Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60116, Indonesia; Corresponding author. Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology and System Engineering, Institut Teknologi Sepuluh Nopember, 60111, Indonesia.Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60116, Indonesia; Graduate School of Science and Technology, Kumamoto University, Kurokami, Kumamoto, 860-8555, JapanDepartment of Biology, Faculty Sciences and Technology, Universitas Airlangga, Campus C, Surabaya, 60115, IndonesiaGraduate School of Science and Technology, Kumamoto University, Kurokami, Kumamoto, 860-8555, JapanSchool of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60116, IndonesiaDepartment of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60116, IndonesiaDepartment of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60116, IndonesiaVaccine Formulation Research Group, Professor Nidom Foundation, Surabaya, 60293, IndonesiaDepartment of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, Taiwan, 912301This work utilizes tailored – Cu2O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of Klebsiella pneumoniae, and 98.92 % of SARS-CoV Delta within 1 min under visible light. Cu2O QDs efficiently reduced 99.25 % viability of 4T1 cancer cells in 15 min while maintaining more than 85 % viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu2O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.http://www.sciencedirect.com/science/article/pii/S2666016425001550Cu2O QDsPathogenPhotodynamic-therapyUltrafastSelective-cytotoxicity |
| spellingShingle | Azzah Dyah Pramata Farhan Aryo Hutomo Febriyansyah Saputra Paundra Rizky Pratama Taras Geonovive De Yenarosa Sutarsis Sigit Tri Wicaksono Agung Purniawan Revianny Nidom Shao-Yang Hu Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light Case Studies in Chemical and Environmental Engineering Cu2O QDs Pathogen Photodynamic-therapy Ultrafast Selective-cytotoxicity |
| title | Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light |
| title_full | Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light |
| title_fullStr | Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light |
| title_full_unstemmed | Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light |
| title_short | Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light |
| title_sort | cu2o quantum dots redefining photodynamic therapy with one minute pathogen inactivation under visible light |
| topic | Cu2O QDs Pathogen Photodynamic-therapy Ultrafast Selective-cytotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2666016425001550 |
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