Hepatoprotective Potential of Sargassum muticum against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway
Liver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus (DM). The methanolic extract of Sargassum muticum (MESM) plays a hepatoprotective role in streptozotocin- (STZ-) induced hepatic injury. In this study, STZ exposure induced diabetes that augmented hepatic da...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/7958701 |
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| author | Mohammed M. Safhi Mohammad Firoz Alam Sivagurunathan Moni Sivakumar Tarique Anwer |
| author_facet | Mohammed M. Safhi Mohammad Firoz Alam Sivagurunathan Moni Sivakumar Tarique Anwer |
| author_sort | Mohammed M. Safhi |
| collection | DOAJ |
| description | Liver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus (DM). The methanolic extract of Sargassum muticum (MESM) plays a hepatoprotective role in streptozotocin- (STZ-) induced hepatic injury. In this study, STZ exposure induced diabetes that augmented hepatic damage, which was reflected in serum enzyme markers, the cytokine network, and caspase-3 and caspase-9 levels in Group 2. Exposure to the MESM tremendously modulated the levels of hepatic enzyme markers ALP, ACP, ALT, and AST in Groups 3 and 4. The cytokine network was well regulated by suppressing the release of cytokines, and the levels of caspase-3 and caspase-9 were also reduced in Groups 3 and 4. The present study suggests that MESM treatment at 200 and 500 mg protected the liver and also minimizes the glucose level. Thus, the MESM plays a key role in rejuvenating the liver and can modulate diabetes’s pathogenic effect by reducing the glucose level. |
| format | Article |
| id | doaj-art-2707f6d2122c4c85be362d0dab83a603 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-2707f6d2122c4c85be362d0dab83a6032025-02-03T01:21:29ZengWileyAnalytical Cellular Pathology2210-71772210-71852019-01-01201910.1155/2019/79587017958701Hepatoprotective Potential of Sargassum muticum against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis PathwayMohammed M. Safhi0Mohammad Firoz Alam1Sivagurunathan Moni Sivakumar2Tarique Anwer3Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Saudi ArabiaLiver inflammation and necrosis are the foremost problems interlinked with diabetes mellitus (DM). The methanolic extract of Sargassum muticum (MESM) plays a hepatoprotective role in streptozotocin- (STZ-) induced hepatic injury. In this study, STZ exposure induced diabetes that augmented hepatic damage, which was reflected in serum enzyme markers, the cytokine network, and caspase-3 and caspase-9 levels in Group 2. Exposure to the MESM tremendously modulated the levels of hepatic enzyme markers ALP, ACP, ALT, and AST in Groups 3 and 4. The cytokine network was well regulated by suppressing the release of cytokines, and the levels of caspase-3 and caspase-9 were also reduced in Groups 3 and 4. The present study suggests that MESM treatment at 200 and 500 mg protected the liver and also minimizes the glucose level. Thus, the MESM plays a key role in rejuvenating the liver and can modulate diabetes’s pathogenic effect by reducing the glucose level.http://dx.doi.org/10.1155/2019/7958701 |
| spellingShingle | Mohammed M. Safhi Mohammad Firoz Alam Sivagurunathan Moni Sivakumar Tarique Anwer Hepatoprotective Potential of Sargassum muticum against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway Analytical Cellular Pathology |
| title | Hepatoprotective Potential of Sargassum muticum against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway |
| title_full | Hepatoprotective Potential of Sargassum muticum against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway |
| title_fullStr | Hepatoprotective Potential of Sargassum muticum against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway |
| title_full_unstemmed | Hepatoprotective Potential of Sargassum muticum against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway |
| title_short | Hepatoprotective Potential of Sargassum muticum against STZ-Induced Diabetic Liver Damage in Wistar Rats by Inhibiting Cytokines and the Apoptosis Pathway |
| title_sort | hepatoprotective potential of sargassum muticum against stz induced diabetic liver damage in wistar rats by inhibiting cytokines and the apoptosis pathway |
| url | http://dx.doi.org/10.1155/2019/7958701 |
| work_keys_str_mv | AT mohammedmsafhi hepatoprotectivepotentialofsargassummuticumagainststzinduceddiabeticliverdamageinwistarratsbyinhibitingcytokinesandtheapoptosispathway AT mohammadfirozalam hepatoprotectivepotentialofsargassummuticumagainststzinduceddiabeticliverdamageinwistarratsbyinhibitingcytokinesandtheapoptosispathway AT sivagurunathanmonisivakumar hepatoprotectivepotentialofsargassummuticumagainststzinduceddiabeticliverdamageinwistarratsbyinhibitingcytokinesandtheapoptosispathway AT tariqueanwer hepatoprotectivepotentialofsargassummuticumagainststzinduceddiabeticliverdamageinwistarratsbyinhibitingcytokinesandtheapoptosispathway |