Validation of Parkinson’s Disease-Related Questionnaires in South Africa
Background. There are very few epidemiological studies investigating Parkinson’s disease (PD) in Africa. The hundreds of local languages and dialects make traditional screening and clinical evaluation tools difficult to use. Objective. The objective of the study was to validate two commonly used PD...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2020/7542138 |
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| author | Gill Nelson Ntombizodwa Ndlovu Nicola Christofides Tintswalo M. Hlungwani Irene Faust Brad A. Racette |
| author_facet | Gill Nelson Ntombizodwa Ndlovu Nicola Christofides Tintswalo M. Hlungwani Irene Faust Brad A. Racette |
| author_sort | Gill Nelson |
| collection | DOAJ |
| description | Background. There are very few epidemiological studies investigating Parkinson’s disease (PD) in Africa. The hundreds of local languages and dialects make traditional screening and clinical evaluation tools difficult to use. Objective. The objective of the study was to validate two commonly used PD questionnaires in an African population. Methods. The PD Screening Questionnaire (PDSQ) and Parkinson’s Disease Questionnaire (PDQ-39) were modified and translated into Afrikaans, Setswana, and isiZulu and administered to a sample of healthy local residents. We assessed the internal consistencies and cluster characteristics of the questionnaires, using a Cronbach’s alpha test and exploratory factor analysis. The questionnaires were then administered to a population-based sample of 416 research participants. We evaluated the correlations between the questionnaires and both a timed motor task and the Unified Parkinson’s Disease Rating Scale motor subsection 3 (UPDRS3), using locally weighted scatterplot smoothing (LOWESS) regression analysis and Spearman’s rank correlation. Results. Both questionnaires had high overall internal consistency (Cronbach’s alpha = 0.86 and 0.95, respectively). The modified PDQ-39 had evidence of five subscales, with Factor 1 explaining 57% and Factor 2 explaining 14%, of the variance in responses. The PDSQ and PDQ-39 scores were correlated with the UPDRS3 score (ρ = 0.35, P<0.001; and ρ = 0.28, P<0.001, respectively). Conclusion. The translated PDSQ and PDQ-39 questionnaires demonstrated high internal consistency and correlations with clinical severity of parkinsonism and a timed motor task, suggesting that they are valid tools for field-based epidemiological studies. |
| format | Article |
| id | doaj-art-26fd35bbe4c042e184c3989826f114a2 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-26fd35bbe4c042e184c3989826f114a22025-02-03T01:05:05ZengWileyParkinson's Disease2090-80832042-00802020-01-01202010.1155/2020/75421387542138Validation of Parkinson’s Disease-Related Questionnaires in South AfricaGill Nelson0Ntombizodwa Ndlovu1Nicola Christofides2Tintswalo M. Hlungwani3Irene Faust4Brad A. Racette5School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St Andrews Rd, Parktown, 2193, South AfricaSchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St Andrews Rd, Parktown, 2193, South AfricaSchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St Andrews Rd, Parktown, 2193, South AfricaSchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St Andrews Rd, Parktown, 2193, South AfricaDepartment of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, Missouri 63110, USASchool of Public Health, Faculty of Health Sciences, University of the Witwatersrand, 27 St Andrews Rd, Parktown, 2193, South AfricaBackground. There are very few epidemiological studies investigating Parkinson’s disease (PD) in Africa. The hundreds of local languages and dialects make traditional screening and clinical evaluation tools difficult to use. Objective. The objective of the study was to validate two commonly used PD questionnaires in an African population. Methods. The PD Screening Questionnaire (PDSQ) and Parkinson’s Disease Questionnaire (PDQ-39) were modified and translated into Afrikaans, Setswana, and isiZulu and administered to a sample of healthy local residents. We assessed the internal consistencies and cluster characteristics of the questionnaires, using a Cronbach’s alpha test and exploratory factor analysis. The questionnaires were then administered to a population-based sample of 416 research participants. We evaluated the correlations between the questionnaires and both a timed motor task and the Unified Parkinson’s Disease Rating Scale motor subsection 3 (UPDRS3), using locally weighted scatterplot smoothing (LOWESS) regression analysis and Spearman’s rank correlation. Results. Both questionnaires had high overall internal consistency (Cronbach’s alpha = 0.86 and 0.95, respectively). The modified PDQ-39 had evidence of five subscales, with Factor 1 explaining 57% and Factor 2 explaining 14%, of the variance in responses. The PDSQ and PDQ-39 scores were correlated with the UPDRS3 score (ρ = 0.35, P<0.001; and ρ = 0.28, P<0.001, respectively). Conclusion. The translated PDSQ and PDQ-39 questionnaires demonstrated high internal consistency and correlations with clinical severity of parkinsonism and a timed motor task, suggesting that they are valid tools for field-based epidemiological studies.http://dx.doi.org/10.1155/2020/7542138 |
| spellingShingle | Gill Nelson Ntombizodwa Ndlovu Nicola Christofides Tintswalo M. Hlungwani Irene Faust Brad A. Racette Validation of Parkinson’s Disease-Related Questionnaires in South Africa Parkinson's Disease |
| title | Validation of Parkinson’s Disease-Related Questionnaires in South Africa |
| title_full | Validation of Parkinson’s Disease-Related Questionnaires in South Africa |
| title_fullStr | Validation of Parkinson’s Disease-Related Questionnaires in South Africa |
| title_full_unstemmed | Validation of Parkinson’s Disease-Related Questionnaires in South Africa |
| title_short | Validation of Parkinson’s Disease-Related Questionnaires in South Africa |
| title_sort | validation of parkinson s disease related questionnaires in south africa |
| url | http://dx.doi.org/10.1155/2020/7542138 |
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