The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction
Natriuretic peptides (NPs) are entered in current guidelines for heart failure (HF) diagnosis and management because of their high specificity and sensibility in screening patients with acute dyspnea. Due to their availability and relatively low cost, they became the first step examinations in HF pa...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/784670 |
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| author | Alberto Palazzuoli Matteo Beltrami Gaetano Ruocco Marco Pellegrini Ranuccio Nuti |
| author_facet | Alberto Palazzuoli Matteo Beltrami Gaetano Ruocco Marco Pellegrini Ranuccio Nuti |
| author_sort | Alberto Palazzuoli |
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| description | Natriuretic peptides (NPs) are entered in current guidelines for heart failure (HF) diagnosis and management because of their high specificity and sensibility in screening patients with acute dyspnea. Due to their availability and relatively low cost, they became the first step examinations in HF patients evaluation at hospital admission together with clinical and chest radiography examination. NPs are released following any cardiac haemodynamic stress due to volume or pressure overload and should be considered as a mirror of cardiac condition helping in recognizing patients with poor outcome. Moreover, the exact role of NPs in early HF stages, in isolated diastolic dysfunction, and in general population is questioned. Several promising reports described their potential role; however, the wide cut-off definition, inclusion criteria, and intrinsic measurement biases do not actually consent to their clinical application in these settings. A multimodality strategy including both NPs and imaging studies appears to be the best strategy to define the cardiac dysfunction etiology and its severity as well as to identify patients with higher risk. In this review, we describe the current and potential role of NPs in patients with asymptomatic cardiac insufficiency, evaluating the requirement to obtain a better standardization for imaging as for laboratory criteria. |
| format | Article |
| id | doaj-art-26f907862f0340cab9a02e4bce78b70c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-26f907862f0340cab9a02e4bce78b70c2025-02-03T01:24:32ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/784670784670The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular DysfunctionAlberto Palazzuoli0Matteo Beltrami1Gaetano Ruocco2Marco Pellegrini3Ranuccio Nuti4Department of Internal Medicine and Metabolic Diseases, Cardiology Section, Le Scotte Hospital, 53100 Siena, ItalyDepartment of Internal Medicine and Metabolic Diseases, Cardiology Section, Le Scotte Hospital, 53100 Siena, ItalyDepartment of Internal Medicine and Metabolic Diseases, Cardiology Section, Le Scotte Hospital, 53100 Siena, ItalyDepartment of Internal Medicine and Metabolic Diseases, Cardiology Section, Le Scotte Hospital, 53100 Siena, ItalyDepartment of Internal Medicine and Metabolic Diseases, Cardiology Section, Le Scotte Hospital, 53100 Siena, ItalyNatriuretic peptides (NPs) are entered in current guidelines for heart failure (HF) diagnosis and management because of their high specificity and sensibility in screening patients with acute dyspnea. Due to their availability and relatively low cost, they became the first step examinations in HF patients evaluation at hospital admission together with clinical and chest radiography examination. NPs are released following any cardiac haemodynamic stress due to volume or pressure overload and should be considered as a mirror of cardiac condition helping in recognizing patients with poor outcome. Moreover, the exact role of NPs in early HF stages, in isolated diastolic dysfunction, and in general population is questioned. Several promising reports described their potential role; however, the wide cut-off definition, inclusion criteria, and intrinsic measurement biases do not actually consent to their clinical application in these settings. A multimodality strategy including both NPs and imaging studies appears to be the best strategy to define the cardiac dysfunction etiology and its severity as well as to identify patients with higher risk. In this review, we describe the current and potential role of NPs in patients with asymptomatic cardiac insufficiency, evaluating the requirement to obtain a better standardization for imaging as for laboratory criteria.http://dx.doi.org/10.1155/2013/784670 |
| spellingShingle | Alberto Palazzuoli Matteo Beltrami Gaetano Ruocco Marco Pellegrini Ranuccio Nuti The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction The Scientific World Journal |
| title | The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction |
| title_full | The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction |
| title_fullStr | The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction |
| title_full_unstemmed | The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction |
| title_short | The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction |
| title_sort | role of natriuretic peptides for the diagnosis of left ventricular dysfunction |
| url | http://dx.doi.org/10.1155/2013/784670 |
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