Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione
This study shows that human lymphocytes markedly decrease chloramines (long-lived oxidants) generated by polymorphonuclear neutrophils (PMN) after stimulation by phorbol-myristate-acetate or opsonized zymosan. In a cell-free model, reduced glutathione (GSH) scavenged chloramines, giving rise to oxid...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000328 |
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| _version_ | 1832556729384042496 |
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| author | Véronique Witko-Sarsat Anh Thu Nguyen Béatrice Descamps-Latscha |
| author_facet | Véronique Witko-Sarsat Anh Thu Nguyen Béatrice Descamps-Latscha |
| author_sort | Véronique Witko-Sarsat |
| collection | DOAJ |
| description | This study shows that human lymphocytes markedly decrease chloramines (long-lived oxidants) generated by polymorphonuclear neutrophils (PMN) after stimulation by phorbol-myristate-acetate or opsonized zymosan. In a cell-free model, reduced glutathione (GSH) scavenged chloramines, giving rise to oxidized glutathione (GSSG). In the cell system, treatment of lymphocytes with autologous PMN-derived chloramines induced a profound decrease in their total and reduced glutathione (GSH) content and markedly inhibited their proliferate responses to concanavalin-A and, to a lesser extent, phytohaemagglutinin. It is concluded that (i) lymphocytes may play a defensive role against phagocyte-derived oxidative stress by scavenging chloramines, and (ii) as this effect which is mediated by GSH affects lymphocyte proliferative responses, it may help to elucidate the still obscure mechanisms of oxidative stress associated immunodeficiency. |
| format | Article |
| id | doaj-art-26ddd77c16b94ffe84a786f543125d61 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-26ddd77c16b94ffe84a786f543125d612025-02-03T05:44:27ZengWileyMediators of Inflammation0962-93511466-18611993-01-012323524110.1155/S0962935193000328Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathioneVéronique Witko-Sarsat0Anh Thu Nguyen1Béatrice Descamps-Latscha2INSERM U25, Hôpital Necker, 161 rue de Sèvres, Paris 75743, FranceINSERM U25, Hôpital Necker, 161 rue de Sèvres, Paris 75743, FranceINSERM U25, Hôpital Necker, 161 rue de Sèvres, Paris 75743, FranceThis study shows that human lymphocytes markedly decrease chloramines (long-lived oxidants) generated by polymorphonuclear neutrophils (PMN) after stimulation by phorbol-myristate-acetate or opsonized zymosan. In a cell-free model, reduced glutathione (GSH) scavenged chloramines, giving rise to oxidized glutathione (GSSG). In the cell system, treatment of lymphocytes with autologous PMN-derived chloramines induced a profound decrease in their total and reduced glutathione (GSH) content and markedly inhibited their proliferate responses to concanavalin-A and, to a lesser extent, phytohaemagglutinin. It is concluded that (i) lymphocytes may play a defensive role against phagocyte-derived oxidative stress by scavenging chloramines, and (ii) as this effect which is mediated by GSH affects lymphocyte proliferative responses, it may help to elucidate the still obscure mechanisms of oxidative stress associated immunodeficiency.http://dx.doi.org/10.1155/S0962935193000328 |
| spellingShingle | Véronique Witko-Sarsat Anh Thu Nguyen Béatrice Descamps-Latscha Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione Mediators of Inflammation |
| title | Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione |
| title_full | Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione |
| title_fullStr | Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione |
| title_full_unstemmed | Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione |
| title_short | Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione |
| title_sort | immunomodulatory role of phagocyte derived chloramines involving lymphocyte glutathione |
| url | http://dx.doi.org/10.1155/S0962935193000328 |
| work_keys_str_mv | AT veroniquewitkosarsat immunomodulatoryroleofphagocytederivedchloraminesinvolvinglymphocyteglutathione AT anhthunguyen immunomodulatoryroleofphagocytederivedchloraminesinvolvinglymphocyteglutathione AT beatricedescampslatscha immunomodulatoryroleofphagocytederivedchloraminesinvolvinglymphocyteglutathione |