Metasurface-enhanced biomedical spectroscopy

Enhancing the sensitivity of biomedical spectroscopy is crucial for advancing medical research and diagnostics. Metasurfaces have emerged as powerful platforms for enhancing the sensitivity of various biomedical spectral detection technologies. This capability arises from their unparalleled ability...

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Main Authors: Li Qiang, Yu Shiwang, Li Zhancheng, Liu Wenwei, Cheng Hua, Chen Shuqi
Format: Article
Language:English
Published: De Gruyter 2025-01-01
Series:Nanophotonics
Subjects:
Online Access:https://doi.org/10.1515/nanoph-2024-0589
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author Li Qiang
Yu Shiwang
Li Zhancheng
Liu Wenwei
Cheng Hua
Chen Shuqi
author_facet Li Qiang
Yu Shiwang
Li Zhancheng
Liu Wenwei
Cheng Hua
Chen Shuqi
author_sort Li Qiang
collection DOAJ
description Enhancing the sensitivity of biomedical spectroscopy is crucial for advancing medical research and diagnostics. Metasurfaces have emerged as powerful platforms for enhancing the sensitivity of various biomedical spectral detection technologies. This capability arises from their unparalleled ability to improve interactions between light and matter through the localization and enhancement of light fields. In this article, we review representative approaches and recent advances in metasurface-enhanced biomedical spectroscopy. We provide a comprehensive discussion of various biomedical spectral detection technologies enhanced by metasurfaces, including infrared spectroscopy, Raman spectroscopy, fluorescence spectroscopy, and other spectral modalities. We demonstrate the advantages of metasurfaces in improving detection sensitivity, reducing detection limits, and achieving rapid biomolecule detection while discussing the challenges associated with the design, preparation, and stability of metasurfaces in biomedical detection procedures. Finally, we explore future development trends of metasurfaces for enhancing biological detection sensitivity and emphasize their wide-ranging applications.
format Article
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institution OA Journals
issn 2192-8614
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publishDate 2025-01-01
publisher De Gruyter
record_format Article
series Nanophotonics
spelling doaj-art-26dc297e9d4b4799a0f33f53b6443d4a2025-08-20T02:28:49ZengDe GruyterNanophotonics2192-86142025-01-011481045106810.1515/nanoph-2024-0589Metasurface-enhanced biomedical spectroscopyLi Qiang0Yu Shiwang1Li Zhancheng2Liu Wenwei3Cheng Hua4Chen Shuqi5The Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, School of Physics and TEDA Institute of Applied Physics, 12538Nankai University, Tianjin300071, ChinaThe Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, School of Physics and TEDA Institute of Applied Physics, 12538Nankai University, Tianjin300071, ChinaThe Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, School of Physics and TEDA Institute of Applied Physics, 12538Nankai University, Tianjin300071, ChinaThe Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, School of Physics and TEDA Institute of Applied Physics, 12538Nankai University, Tianjin300071, ChinaThe Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, School of Physics and TEDA Institute of Applied Physics, 12538Nankai University, Tianjin300071, ChinaThe Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, School of Physics and TEDA Institute of Applied Physics, 12538Nankai University, Tianjin300071, ChinaEnhancing the sensitivity of biomedical spectroscopy is crucial for advancing medical research and diagnostics. Metasurfaces have emerged as powerful platforms for enhancing the sensitivity of various biomedical spectral detection technologies. This capability arises from their unparalleled ability to improve interactions between light and matter through the localization and enhancement of light fields. In this article, we review representative approaches and recent advances in metasurface-enhanced biomedical spectroscopy. We provide a comprehensive discussion of various biomedical spectral detection technologies enhanced by metasurfaces, including infrared spectroscopy, Raman spectroscopy, fluorescence spectroscopy, and other spectral modalities. We demonstrate the advantages of metasurfaces in improving detection sensitivity, reducing detection limits, and achieving rapid biomolecule detection while discussing the challenges associated with the design, preparation, and stability of metasurfaces in biomedical detection procedures. Finally, we explore future development trends of metasurfaces for enhancing biological detection sensitivity and emphasize their wide-ranging applications.https://doi.org/10.1515/nanoph-2024-0589metasurfacebiomedical spectroscopydetection sensitivityinfrared spectroscopyraman spectroscopy
spellingShingle Li Qiang
Yu Shiwang
Li Zhancheng
Liu Wenwei
Cheng Hua
Chen Shuqi
Metasurface-enhanced biomedical spectroscopy
Nanophotonics
metasurface
biomedical spectroscopy
detection sensitivity
infrared spectroscopy
raman spectroscopy
title Metasurface-enhanced biomedical spectroscopy
title_full Metasurface-enhanced biomedical spectroscopy
title_fullStr Metasurface-enhanced biomedical spectroscopy
title_full_unstemmed Metasurface-enhanced biomedical spectroscopy
title_short Metasurface-enhanced biomedical spectroscopy
title_sort metasurface enhanced biomedical spectroscopy
topic metasurface
biomedical spectroscopy
detection sensitivity
infrared spectroscopy
raman spectroscopy
url https://doi.org/10.1515/nanoph-2024-0589
work_keys_str_mv AT liqiang metasurfaceenhancedbiomedicalspectroscopy
AT yushiwang metasurfaceenhancedbiomedicalspectroscopy
AT lizhancheng metasurfaceenhancedbiomedicalspectroscopy
AT liuwenwei metasurfaceenhancedbiomedicalspectroscopy
AT chenghua metasurfaceenhancedbiomedicalspectroscopy
AT chenshuqi metasurfaceenhancedbiomedicalspectroscopy