The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns
Objective: Although the role of thyroid hormones in functional and anatomical closure of patent ductus arteriosus (PDA) is well known, their effects on the medical or surgical closure of PDA in newborns remain unclear. This study aimed to assess the correlation between thyroid function tests and PDA...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2023-09-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-25853 |
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| author | Basak KAYA Hasan AKDUMAN Dilek DILLI Semra CETINKAYA Ahmet OKTEM Utku Arman ORUN Mehmet TASAR Aysegul ZENCIROGLU |
| author_facet | Basak KAYA Hasan AKDUMAN Dilek DILLI Semra CETINKAYA Ahmet OKTEM Utku Arman ORUN Mehmet TASAR Aysegul ZENCIROGLU |
| author_sort | Basak KAYA |
| collection | DOAJ |
| description | Objective: Although the role of thyroid hormones in functional and anatomical closure of patent ductus arteriosus (PDA) is well known, their effects on the medical or surgical closure of PDA in newborns remain unclear. This study aimed to assess the correlation between thyroid function tests and PDA closure through medical or surgical interventions in newborns.
Methods: This retrospective study was conducted on 65 newborns diagnosed with hemodynamically significant PDA (hs-PDA), with a premature rate of 81.5% (n=53). The subjects were divided into two groups according to the nature of the ductal closure as medically responsive 'MR-PDA' or surgically treated 'ST-PDA'. The groups were compared in terms of thyroid hormone levels and other clinical parameters.
Results: Thirty-three (51%) of all 65 patients had PDA and responded to medical treatment. Gestational week, birth weight, and mode of delivery were similar between the medical and surgical treatment groups (p>0.05). Free thyroxine levels were significantly lower in the MR-PDA group than in the ST-PDA group (p=0.01).
Conclusions: Because hs-PDA is associated with increased morbidity and mortality in the neonatal period, especially in premature infants, we hypothesize that thyroid hormone levels may play a role in the closure of hs-PDA. |
| format | Article |
| id | doaj-art-26b54c4bb70944bf8d7948bd1e6dc2db |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-26b54c4bb70944bf8d7948bd1e6dc2db2025-01-30T07:02:58ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062023-09-0138318719210.4274/MMJ.galenos.2023.25853MEDJ-25853The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in NewbornsBasak KAYA0Hasan AKDUMAN1Dilek DILLI2Semra CETINKAYA3Ahmet OKTEM4Utku Arman ORUN5Mehmet TASAR6Aysegul ZENCIROGLU7University of Health Sciences of Turkey, Ankara Dr. Sami Ulus Gynecology and Pediatrics Training and Research Hospital, Clinic of Neonatology, Ankara, TurkeyUniversity of Health Sciences of Turkey, Ankara Dr. Sami Ulus Gynecology and Pediatrics Training and Research Hospital, Clinic of Neonatology, Ankara, TurkeyUniversity of Health Sciences of Turkey, Ankara Dr. Sami Ulus Gynecology and Pediatrics Training and Research Hospital, Clinic of Neonatology, Ankara, TurkeyUniversity of Health Sciences of Turkey, Ankara Dr. Sami Ulus Gynecology and Pediatrics Training and Research Hospital, Clinic of Pediatric Endocrinology, Ankara, TurkeyUniversity of Health Sciences of Turkey, Ankara Dr. Sami Ulus Gynecology and Pediatrics Training and Research Hospital, Clinic of Neonatology, Ankara, TurkeyUniversity of Health Sciences of Turkey, Ankara Dr. Sami Ulus Gynecology and Pediatrics Training and Research Hospital, Clinic of Pediatric Cardiology, Ankara, TurkeyUniversity of Health Sciences of Turkey, Ankara Dr. Sami Ulus Gynecology and Pediatrics Training and Research Hospital, Clinic of Pediatric Cardiovascular Surgery, Ankara, TurkeyUniversity of Health Sciences of Turkey, Ankara Dr. Sami Ulus Gynecology and Pediatrics Training and Research Hospital, Clinic of Neonatology, Ankara, TurkeyObjective: Although the role of thyroid hormones in functional and anatomical closure of patent ductus arteriosus (PDA) is well known, their effects on the medical or surgical closure of PDA in newborns remain unclear. This study aimed to assess the correlation between thyroid function tests and PDA closure through medical or surgical interventions in newborns. Methods: This retrospective study was conducted on 65 newborns diagnosed with hemodynamically significant PDA (hs-PDA), with a premature rate of 81.5% (n=53). The subjects were divided into two groups according to the nature of the ductal closure as medically responsive 'MR-PDA' or surgically treated 'ST-PDA'. The groups were compared in terms of thyroid hormone levels and other clinical parameters. Results: Thirty-three (51%) of all 65 patients had PDA and responded to medical treatment. Gestational week, birth weight, and mode of delivery were similar between the medical and surgical treatment groups (p>0.05). Free thyroxine levels were significantly lower in the MR-PDA group than in the ST-PDA group (p=0.01). Conclusions: Because hs-PDA is associated with increased morbidity and mortality in the neonatal period, especially in premature infants, we hypothesize that thyroid hormone levels may play a role in the closure of hs-PDA.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-25853newbornprematurepatent ductus arteriosusthyroid function tests |
| spellingShingle | Basak KAYA Hasan AKDUMAN Dilek DILLI Semra CETINKAYA Ahmet OKTEM Utku Arman ORUN Mehmet TASAR Aysegul ZENCIROGLU The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns Medeniyet Medical Journal newborn premature patent ductus arteriosus thyroid function tests |
| title | The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns |
| title_full | The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns |
| title_fullStr | The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns |
| title_full_unstemmed | The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns |
| title_short | The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns |
| title_sort | effects of thyroid hormone levels on patent ductus arteriosus closure in newborns |
| topic | newborn premature patent ductus arteriosus thyroid function tests |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-25853 |
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