Biochemical Evolution and Histological Response of Patients with Hepatitis C Undergoing Antiviral Therapy.
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| Language: | Spanish |
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Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2011-07-01
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| Series: | Medisur |
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| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/1484 |
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| author | Omar Julián Hernández Ojeda Marcos Félix Osorio Pagola Orelvis Martínez Martínez Denis Monzón Vega Mabel Vega Galindo |
| author_facet | Omar Julián Hernández Ojeda Marcos Félix Osorio Pagola Orelvis Martínez Martínez Denis Monzón Vega Mabel Vega Galindo |
| author_sort | Omar Julián Hernández Ojeda |
| collection | DOAJ |
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mso-pagination:widow-orphan; font-size:12.0pt; mso-bidi-font-size:10.0pt; font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:ES-TRAD; mso-fareast-language:ES;} span.Textoindependiente2Car {mso-style-name:"Texto independiente 2 Car"; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Texto independiente 2"; mso-ansi-font-size:12.0pt; mso-ansi-language:ES-TRAD; mso-fareast-language:ES;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt;} @page Section1 {size:8.5in 11.0in; margin:1.0in 1.0in 1.0in 1.0in; mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;} div.Section1 {page:Section1;} --> <!--[if gte mso 10]> <mce:style><! /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} --> <!--[endif]--><p><strong>Fundamento</strong>: la hepatitis C es uno de los principales problemas de salud a nivel mundial y la indicación más frecuente de transplante hepático en muchos países. <br /><strong>Objetivo</strong>: determinar la evolución bioquímica y respuesta histológica de pacientes con hepatitis crónica tipo C bajo tratamiento con Interferón alfa 2b recombinante y ribavirina atendidos en consulta provincial de Hepatología. <strong><br />Métodos</strong>: estudio observacional y descriptivo, en 31 pacientes portadores del virus de la hepatitis C, remitidos a la consulta de Hepatología Provincial de Cienfuegos en el Hospital Universitario “Dr. Gustavo Aldereguía Lima”, entre enero de 2007 y junio de 2009; y tratados con interferon alfa 2b recombinante más ribavirina. Se estudiaron las variables: edad, sexo, posible vía de infección, valores séricos de alanito aminotransferasa, evaluación bioquímica (al concluir el tratamiento y al finalizar el seguimiento) y respuesta histológica. Para la evaluación de la actividad histológica de las lesiones hepáticas crónicas se empleó el índice de Knodell. Para comparar los resultados (respuesta bioquímica y la respuesta histológica) antes y después del tratamiento se empleó la Prueba de los Signos. <strong><br />Resultados</strong>: El sexo femenino predominó en la muestra (58,1 %). La edad promedio fue de 45,5±11,6 años. La vía posible de trasmisión no se pudo identificar en 51,6 % de los pacientes. El tratamiento quirúrgico fue identificado como vía de infección en el 22,6 %, seguido del tratamiento parenteral reiterado (16,1 %). <strong><br />Conclusión</strong>: al finalizar el tratamiento se obtuvo un mayor porcentaje de respuesta en cuanto a la evolución bioquímica y a la respuesta histológica.</p> |
| format | Article |
| id | doaj-art-26ad8e1c8d49454ab091535f9fb62e55 |
| institution | Kabale University |
| issn | 1727-897X |
| language | Spanish |
| publishDate | 2011-07-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj-art-26ad8e1c8d49454ab091535f9fb62e552025-01-30T21:28:44ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2011-07-0193250258745Biochemical Evolution and Histological Response of Patients with Hepatitis C Undergoing Antiviral Therapy.Omar Julián Hernández Ojeda0Marcos Félix Osorio Pagola1Orelvis Martínez Martínez2Denis Monzón Vega3Mabel Vega Galindo4Hospital Provincial "Gustavo Aldereguía Lima"Hospital Provincial "Gustavo Aldereguía Lima"Hospital Provincial "Abel Santa Maria Cuadrado" Pinar del RíoUniversidad de Ciencias Médicas de CienfuegosCentro Provincial de Higiene, Epidemiología y Microbiología. 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--> <!--[endif]--> <!-- /* Font Definitions */ @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-1610611985 1107304683 0 0 159 0;} @font-face {font-family:Tahoma; panose-1:2 11 6 4 3 5 4 4 2 4; mso-font-charset:0; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-520082689 -1073717157 41 0 66047 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0in; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:ES; mso-fareast-language:ES;} p.MsoBodyText2, li.MsoBodyText2, div.MsoBodyText2 {mso-style-unhide:no; mso-style-link:"Texto independiente 2 Car"; margin:0in; margin-bottom:.0001pt; text-align:justify; line-height:150%; mso-pagination:widow-orphan; font-size:12.0pt; mso-bidi-font-size:10.0pt; font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:ES-TRAD; mso-fareast-language:ES;} span.Textoindependiente2Car {mso-style-name:"Texto independiente 2 Car"; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Texto independiente 2"; mso-ansi-font-size:12.0pt; mso-ansi-language:ES-TRAD; mso-fareast-language:ES;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt;} @page Section1 {size:8.5in 11.0in; margin:1.0in 1.0in 1.0in 1.0in; mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;} div.Section1 {page:Section1;} --> <!--[if gte mso 10]> <mce:style><! /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} --> <!--[endif]--><p><strong>Fundamento</strong>: la hepatitis C es uno de los principales problemas de salud a nivel mundial y la indicación más frecuente de transplante hepático en muchos países. <br /><strong>Objetivo</strong>: determinar la evolución bioquímica y respuesta histológica de pacientes con hepatitis crónica tipo C bajo tratamiento con Interferón alfa 2b recombinante y ribavirina atendidos en consulta provincial de Hepatología. <strong><br />Métodos</strong>: estudio observacional y descriptivo, en 31 pacientes portadores del virus de la hepatitis C, remitidos a la consulta de Hepatología Provincial de Cienfuegos en el Hospital Universitario “Dr. Gustavo Aldereguía Lima”, entre enero de 2007 y junio de 2009; y tratados con interferon alfa 2b recombinante más ribavirina. Se estudiaron las variables: edad, sexo, posible vía de infección, valores séricos de alanito aminotransferasa, evaluación bioquímica (al concluir el tratamiento y al finalizar el seguimiento) y respuesta histológica. Para la evaluación de la actividad histológica de las lesiones hepáticas crónicas se empleó el índice de Knodell. Para comparar los resultados (respuesta bioquímica y la respuesta histológica) antes y después del tratamiento se empleó la Prueba de los Signos. <strong><br />Resultados</strong>: El sexo femenino predominó en la muestra (58,1 %). La edad promedio fue de 45,5±11,6 años. La vía posible de trasmisión no se pudo identificar en 51,6 % de los pacientes. El tratamiento quirúrgico fue identificado como vía de infección en el 22,6 %, seguido del tratamiento parenteral reiterado (16,1 %). <strong><br />Conclusión</strong>: al finalizar el tratamiento se obtuvo un mayor porcentaje de respuesta en cuanto a la evolución bioquímica y a la respuesta histológica.</p>http://medisur.sld.cu/index.php/medisur/article/view/1484hepatitis viral humanahepatitis c, virus hepatitis cinterferón alfa-2b. ribavirina |
| spellingShingle | Omar Julián Hernández Ojeda Marcos Félix Osorio Pagola Orelvis Martínez Martínez Denis Monzón Vega Mabel Vega Galindo Biochemical Evolution and Histological Response of Patients with Hepatitis C Undergoing Antiviral Therapy. Medisur hepatitis viral humana hepatitis c, virus hepatitis c interferón alfa-2b. ribavirina |
| title | Biochemical Evolution and Histological Response of Patients with Hepatitis C Undergoing Antiviral Therapy. |
| title_full | Biochemical Evolution and Histological Response of Patients with Hepatitis C Undergoing Antiviral Therapy. |
| title_fullStr | Biochemical Evolution and Histological Response of Patients with Hepatitis C Undergoing Antiviral Therapy. |
| title_full_unstemmed | Biochemical Evolution and Histological Response of Patients with Hepatitis C Undergoing Antiviral Therapy. |
| title_short | Biochemical Evolution and Histological Response of Patients with Hepatitis C Undergoing Antiviral Therapy. |
| title_sort | biochemical evolution and histological response of patients with hepatitis c undergoing antiviral therapy |
| topic | hepatitis viral humana hepatitis c, virus hepatitis c interferón alfa-2b. ribavirina |
| url | http://medisur.sld.cu/index.php/medisur/article/view/1484 |
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