Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography
Purpose. To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves’ disease and orbitopathy (GO). Methods. Thirty-six eyes of 18 patients with GO and 36 eyes...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1454616 |
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| author | Alice Bruscolini Maurizio La Cava Magda Gharbiya Marta Sacchetti Lucia Restivo Chiara Nardella Marco Marenco Alessandro Lambiase |
| author_facet | Alice Bruscolini Maurizio La Cava Magda Gharbiya Marta Sacchetti Lucia Restivo Chiara Nardella Marco Marenco Alessandro Lambiase |
| author_sort | Alice Bruscolini |
| collection | DOAJ |
| description | Purpose. To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves’ disease and orbitopathy (GO). Methods. Thirty-six eyes of 18 patients with GO and 36 eyes of 18 age-matched control subjects were included in this retrospective observational study. All the subjects underwent a complete ophthalmological evaluation, including clinical activity score (CAS) and exophthalmometry. The SDOCT images of the choroid were obtained by EDI modality. Results. Choroidal thickness was significantly increased in GO than in control eyes (p<0.01). A significant correlation was found between choroidal thickness and CAS, proptosis, and the duration of disease (p<0.05). Conclusion. This study shows that choroidal thickness, evaluated with EDI-OCT, is significantly increased in patients with GO and correlates with the activity of the disease, proptosis, and duration of the disease. The choroidal thickening may reflect the ocular hemodynamic changes, and enhanced depth imaging optical coherence tomography may be a useful tool for the evaluation of orbital congestion and management of patients with Graves’ disease and orbital involvement. |
| format | Article |
| id | doaj-art-26a7cfb5fffd4bb4a2986b93c8257717 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-26a7cfb5fffd4bb4a2986b93c82577172025-02-03T00:59:44ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/14546161454616Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence TomographyAlice Bruscolini0Maurizio La Cava1Magda Gharbiya2Marta Sacchetti3Lucia Restivo4Chiara Nardella5Marco Marenco6Alessandro Lambiase7Department of Sense Organs, University Sapienza, Rome, ItalyDepartment of Sense Organs, University Sapienza, Rome, ItalyDepartment of Sense Organs, University Sapienza, Rome, ItalyDepartment of Sense Organs, University Sapienza, Rome, ItalyDepartment of Sense Organs, University Sapienza, Rome, ItalyDepartment of Sense Organs, University Sapienza, Rome, ItalyDepartment of Sense Organs, University Sapienza, Rome, ItalyDepartment of Sense Organs, University Sapienza, Rome, ItalyPurpose. To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves’ disease and orbitopathy (GO). Methods. Thirty-six eyes of 18 patients with GO and 36 eyes of 18 age-matched control subjects were included in this retrospective observational study. All the subjects underwent a complete ophthalmological evaluation, including clinical activity score (CAS) and exophthalmometry. The SDOCT images of the choroid were obtained by EDI modality. Results. Choroidal thickness was significantly increased in GO than in control eyes (p<0.01). A significant correlation was found between choroidal thickness and CAS, proptosis, and the duration of disease (p<0.05). Conclusion. This study shows that choroidal thickness, evaluated with EDI-OCT, is significantly increased in patients with GO and correlates with the activity of the disease, proptosis, and duration of the disease. The choroidal thickening may reflect the ocular hemodynamic changes, and enhanced depth imaging optical coherence tomography may be a useful tool for the evaluation of orbital congestion and management of patients with Graves’ disease and orbital involvement.http://dx.doi.org/10.1155/2018/1454616 |
| spellingShingle | Alice Bruscolini Maurizio La Cava Magda Gharbiya Marta Sacchetti Lucia Restivo Chiara Nardella Marco Marenco Alessandro Lambiase Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography Journal of Immunology Research |
| title | Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography |
| title_full | Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography |
| title_fullStr | Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography |
| title_full_unstemmed | Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography |
| title_short | Management of Patients with Graves’ Disease and Orbital Involvement: Role of Spectral Domain Optical Coherence Tomography |
| title_sort | management of patients with graves disease and orbital involvement role of spectral domain optical coherence tomography |
| url | http://dx.doi.org/10.1155/2018/1454616 |
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