Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus
Fungi are an important and common cause of cutaneous infections affecting solid organ transplant recipients. These infections can represent a primary site of infection with the potential for dissemination, or a manifestation of metastatic infection. The high morbidity and mortality associated with t...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2012/272197 |
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| author | Randah Dahlan Ameen Patel Shariq Haider |
| author_facet | Randah Dahlan Ameen Patel Shariq Haider |
| author_sort | Randah Dahlan |
| collection | DOAJ |
| description | Fungi are an important and common cause of cutaneous infections affecting solid organ transplant recipients. These infections can represent a primary site of infection with the potential for dissemination, or a manifestation of metastatic infection. The high morbidity and mortality associated with these infections necessitates urgent therapy with antifungal drugs; however, the interaction between these drugs and immunosuppressive therapies can be a major limitation because of drug toxicity. A case of soft tissue infection of the toe caused by Fusarium chlamydosporum and Candida guilliermondii in a liver transplant patient on sirolimus, who was successfully treated with the new antifungal agent posaconazole, is described. The pharmacokinetic interactions of sirolimus and the new triazoles, and their impact on treatment choices are briefly discussed. |
| format | Article |
| id | doaj-art-26a305d40a364529a5f41c160dae37ea |
| institution | Kabale University |
| issn | 1712-9532 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-26a305d40a364529a5f41c160dae37ea2025-02-03T01:28:11ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322012-01-01232e44e4710.1155/2012/272197Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on SirolimusRandah Dahlan0Ameen Patel1Shariq Haider2Department of Internal Medicine, McMaster University, CanadaDivision of General Internal Medicine, Hamilton Health Sciences, Hamilton, Ontario, CanadaDivision of Infectious Diseases, Hamilton Health Sciences, Hamilton, Ontario, CanadaFungi are an important and common cause of cutaneous infections affecting solid organ transplant recipients. These infections can represent a primary site of infection with the potential for dissemination, or a manifestation of metastatic infection. The high morbidity and mortality associated with these infections necessitates urgent therapy with antifungal drugs; however, the interaction between these drugs and immunosuppressive therapies can be a major limitation because of drug toxicity. A case of soft tissue infection of the toe caused by Fusarium chlamydosporum and Candida guilliermondii in a liver transplant patient on sirolimus, who was successfully treated with the new antifungal agent posaconazole, is described. The pharmacokinetic interactions of sirolimus and the new triazoles, and their impact on treatment choices are briefly discussed.http://dx.doi.org/10.1155/2012/272197 |
| spellingShingle | Randah Dahlan Ameen Patel Shariq Haider Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus |
| title_full | Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus |
| title_fullStr | Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus |
| title_full_unstemmed | Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus |
| title_short | Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus |
| title_sort | successful use of posaconazole to treat invasive cutaneous fungal infection in a liver transplant patient on sirolimus |
| url | http://dx.doi.org/10.1155/2012/272197 |
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