The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up
Depression is one of the most common and persistent nonmotor syndromes occurring in 35% of patients diagnosed with PD. However, little information is known about the longitudinal study of its natural history of depression in PD. In this study, we identified 110 patients who are diagnosed with idiopa...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/362892 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554619657519104 |
|---|---|
| author | Yuan-Yuan Xu Sheng-Han Kuo Zheng Liang Hui Xu Wu-Ruo Feng Cui-Yu Yu Wei-Guo Liu |
| author_facet | Yuan-Yuan Xu Sheng-Han Kuo Zheng Liang Hui Xu Wu-Ruo Feng Cui-Yu Yu Wei-Guo Liu |
| author_sort | Yuan-Yuan Xu |
| collection | DOAJ |
| description | Depression is one of the most common and persistent nonmotor syndromes occurring in 35% of patients diagnosed with PD. However, little information is known about the longitudinal study of its natural history of depression in PD. In this study, we identified 110 patients who are diagnosed with idiopathic PD and recruited them for assessing information about their PD related motor and nonmotor symptoms and rating scales. A follow-up evaluation was performed in 103 patients 30 months later. About 66.7% depressed patients at baseline were still depressed at follow-up, and 24.4% had incident depression among subjects without depression at baseline. Greater decline on MMSE (P=0.029), higher baseline UPDRS-II (P<0.001) score, change of UPDRS-II (P=0.026), and female (P<0.001) were associated with the worsening of HDRS scores. Higher baseline HDRS score (P<0.001) and greater decline on MMSE (P=0.001) were related to the occurrence of depression. In conclusion, cognitive decline is a disease related factor of worsening and the occurrence of depression. Activities of Daily Living (ADL) symptoms in PD and female gender may be crucial factors of increasing depressive symptoms. |
| format | Article |
| id | doaj-art-268703cd9fcb46c1b6b3caf8011b0e58 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-268703cd9fcb46c1b6b3caf8011b0e582025-02-03T05:50:59ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/362892362892The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-UpYuan-Yuan Xu0Sheng-Han Kuo1Zheng Liang2Hui Xu3Wu-Ruo Feng4Cui-Yu Yu5Wei-Guo Liu6Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Neurology, The Neurological Institute of New York, Columbia University Medical Center, New York, NY 10032, USADepartment of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepression is one of the most common and persistent nonmotor syndromes occurring in 35% of patients diagnosed with PD. However, little information is known about the longitudinal study of its natural history of depression in PD. In this study, we identified 110 patients who are diagnosed with idiopathic PD and recruited them for assessing information about their PD related motor and nonmotor symptoms and rating scales. A follow-up evaluation was performed in 103 patients 30 months later. About 66.7% depressed patients at baseline were still depressed at follow-up, and 24.4% had incident depression among subjects without depression at baseline. Greater decline on MMSE (P=0.029), higher baseline UPDRS-II (P<0.001) score, change of UPDRS-II (P=0.026), and female (P<0.001) were associated with the worsening of HDRS scores. Higher baseline HDRS score (P<0.001) and greater decline on MMSE (P=0.001) were related to the occurrence of depression. In conclusion, cognitive decline is a disease related factor of worsening and the occurrence of depression. Activities of Daily Living (ADL) symptoms in PD and female gender may be crucial factors of increasing depressive symptoms.http://dx.doi.org/10.1155/2015/362892 |
| spellingShingle | Yuan-Yuan Xu Sheng-Han Kuo Zheng Liang Hui Xu Wu-Ruo Feng Cui-Yu Yu Wei-Guo Liu The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up Parkinson's Disease |
| title | The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up |
| title_full | The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up |
| title_fullStr | The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up |
| title_full_unstemmed | The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up |
| title_short | The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up |
| title_sort | natural history of depression in parkinson s disease within 30 month follow up |
| url | http://dx.doi.org/10.1155/2015/362892 |
| work_keys_str_mv | AT yuanyuanxu thenaturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT shenghankuo thenaturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT zhengliang thenaturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT huixu thenaturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT wuruofeng thenaturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT cuiyuyu thenaturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT weiguoliu thenaturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT yuanyuanxu naturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT shenghankuo naturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT zhengliang naturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT huixu naturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT wuruofeng naturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT cuiyuyu naturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup AT weiguoliu naturalhistoryofdepressioninparkinsonsdiseasewithin30monthfollowup |