Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
New series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antifungal activity (MIC activity) was evaluated and compared wi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/940586 |
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| author | Shiv K. Gupta P. K. Sharma M. Bansal B. Kumar |
| author_facet | Shiv K. Gupta P. K. Sharma M. Bansal B. Kumar |
| author_sort | Shiv K. Gupta |
| collection | DOAJ |
| description | New series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antifungal activity (MIC activity) was evaluated and compared with standard drugs of ketoconazole. Compounds 3c in the series has shown interesting antifungal activity against both C. albicans and A. niger fungus. In the gratifying result, most of the compounds were found to have moderate antifungal activity. |
| format | Article |
| id | doaj-art-267eb8b461e0429e973929506426dea6 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-267eb8b461e0429e973929506426dea62025-02-03T01:12:08ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018259459710.1155/2011/940586Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazoleShiv K. Gupta0P. K. Sharma1M. Bansal2B. Kumar3Department of Pharmaceutical Science, Shree Ganpati Institute of Technology, NH-24, opp. Jindal Pipes Ltd, Ghaziabad, IndiaMeerut Institute of Engineering and Technology, Partapur Road, Bagpat Croosing, Meerut, IndiaMeerut Institute of Engineering and Technology, Partapur Road, Bagpat Croosing, Meerut, IndiaDepartment of Pharmaceutical Science, Shree Ganpati Institute of Technology, NH-24, opp. Jindal Pipes Ltd, Ghaziabad, IndiaNew series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antifungal activity (MIC activity) was evaluated and compared with standard drugs of ketoconazole. Compounds 3c in the series has shown interesting antifungal activity against both C. albicans and A. niger fungus. In the gratifying result, most of the compounds were found to have moderate antifungal activity.http://dx.doi.org/10.1155/2011/940586 |
| spellingShingle | Shiv K. Gupta P. K. Sharma M. Bansal B. Kumar Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole E-Journal of Chemistry |
| title | Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole |
| title_full | Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole |
| title_fullStr | Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole |
| title_full_unstemmed | Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole |
| title_short | Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole |
| title_sort | synthesis and antifungal activities of 5 o hydroxy phenyl 2 4 aryl 3 chloro 2 azetidinon 1 yl 1 3 4 thiadiazole |
| url | http://dx.doi.org/10.1155/2011/940586 |
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