Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment
More people die annually from cardiovascular diseases than from any other cause. In particular, patients who suffer from myocardial infarction may be affected by ongoing adverse remodeling processes of the heart that may ultimately lead to heart failure. The introduction of stem and progenitor cell-...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/9098523 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548727192027136 |
|---|---|
| author | Julia Günter Petra Wolint Annina Bopp Julia Steiger Elena Cambria Simon P. Hoerstrup Maximilian Y. Emmert |
| author_facet | Julia Günter Petra Wolint Annina Bopp Julia Steiger Elena Cambria Simon P. Hoerstrup Maximilian Y. Emmert |
| author_sort | Julia Günter |
| collection | DOAJ |
| description | More people die annually from cardiovascular diseases than from any other cause. In particular, patients who suffer from myocardial infarction may be affected by ongoing adverse remodeling processes of the heart that may ultimately lead to heart failure. The introduction of stem and progenitor cell-based applications has raised substantial hope for reversing these processes and inducing cardiac regeneration. However, current stem cell therapies using single-cell suspensions have failed to demonstrate long-lasting efficacy due to the overall low retention rate after cell delivery to the myocardium. To overcome this obstacle, the concept of 3D cell culture techniques has been proposed to enhance therapeutic efficacy and cell engraftment based on the simulation of an in vivo-like microenvironment. Of great interest is the use of so-called microtissues or spheroids, which have evolved from their traditional role as in vitro models to their novel role as therapeutic agents. This review will provide an overview of the therapeutic potential of microtissues by addressing primarily cardiovascular regeneration. It will accentuate their advantages compared to other regenerative approaches and summarize the methods for generating clinically applicable microtissues. In addition, this review will illustrate the unique properties of the microenvironment within microtissues that makes them a promising next-generation therapeutic approach. |
| format | Article |
| id | doaj-art-267268849cb84eccb17ad5dd4acf1369 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-267268849cb84eccb17ad5dd4acf13692025-02-03T06:13:14ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/90985239098523Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D MicroenvironmentJulia Günter0Petra Wolint1Annina Bopp2Julia Steiger3Elena Cambria4Simon P. Hoerstrup5Maximilian Y. Emmert6Institute for Regenerative Medicine, University of Zurich, 8044 Zurich, SwitzerlandInstitute for Regenerative Medicine, University of Zurich, 8044 Zurich, SwitzerlandInstitute for Regenerative Medicine, University of Zurich, 8044 Zurich, SwitzerlandInstitute for Regenerative Medicine, University of Zurich, 8044 Zurich, SwitzerlandInstitute for Regenerative Medicine, University of Zurich, 8044 Zurich, SwitzerlandInstitute for Regenerative Medicine, University of Zurich, 8044 Zurich, SwitzerlandInstitute for Regenerative Medicine, University of Zurich, 8044 Zurich, SwitzerlandMore people die annually from cardiovascular diseases than from any other cause. In particular, patients who suffer from myocardial infarction may be affected by ongoing adverse remodeling processes of the heart that may ultimately lead to heart failure. The introduction of stem and progenitor cell-based applications has raised substantial hope for reversing these processes and inducing cardiac regeneration. However, current stem cell therapies using single-cell suspensions have failed to demonstrate long-lasting efficacy due to the overall low retention rate after cell delivery to the myocardium. To overcome this obstacle, the concept of 3D cell culture techniques has been proposed to enhance therapeutic efficacy and cell engraftment based on the simulation of an in vivo-like microenvironment. Of great interest is the use of so-called microtissues or spheroids, which have evolved from their traditional role as in vitro models to their novel role as therapeutic agents. This review will provide an overview of the therapeutic potential of microtissues by addressing primarily cardiovascular regeneration. It will accentuate their advantages compared to other regenerative approaches and summarize the methods for generating clinically applicable microtissues. In addition, this review will illustrate the unique properties of the microenvironment within microtissues that makes them a promising next-generation therapeutic approach.http://dx.doi.org/10.1155/2016/9098523 |
| spellingShingle | Julia Günter Petra Wolint Annina Bopp Julia Steiger Elena Cambria Simon P. Hoerstrup Maximilian Y. Emmert Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment Stem Cells International |
| title | Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment |
| title_full | Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment |
| title_fullStr | Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment |
| title_full_unstemmed | Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment |
| title_short | Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment |
| title_sort | microtissues in cardiovascular medicine regenerative potential based on a 3d microenvironment |
| url | http://dx.doi.org/10.1155/2016/9098523 |
| work_keys_str_mv | AT juliagunter microtissuesincardiovascularmedicineregenerativepotentialbasedona3dmicroenvironment AT petrawolint microtissuesincardiovascularmedicineregenerativepotentialbasedona3dmicroenvironment AT anninabopp microtissuesincardiovascularmedicineregenerativepotentialbasedona3dmicroenvironment AT juliasteiger microtissuesincardiovascularmedicineregenerativepotentialbasedona3dmicroenvironment AT elenacambria microtissuesincardiovascularmedicineregenerativepotentialbasedona3dmicroenvironment AT simonphoerstrup microtissuesincardiovascularmedicineregenerativepotentialbasedona3dmicroenvironment AT maximilianyemmert microtissuesincardiovascularmedicineregenerativepotentialbasedona3dmicroenvironment |