Comparative Genomics Reveals Pathogenicity-Related Loci in Shewanella algae
Shewanella algae is an emerging marine zoonotic pathogen and accounts for considerable mortality and morbidity in compromised hosts. However, there is scarce literature related to the understanding of the genetic background of virulence determinants in S. algae. In this study, we aim to determine th...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2020/9205197 |
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| author | Jui-Hsing Wang Guo-Cheng He Yao-Ting Huang Po-Yu Liu |
| author_facet | Jui-Hsing Wang Guo-Cheng He Yao-Ting Huang Po-Yu Liu |
| author_sort | Jui-Hsing Wang |
| collection | DOAJ |
| description | Shewanella algae is an emerging marine zoonotic pathogen and accounts for considerable mortality and morbidity in compromised hosts. However, there is scarce literature related to the understanding of the genetic background of virulence determinants in S. algae. In this study, we aim to determine the occurrence of common virulence genes in S. algae using whole-genome sequence and comparative genomic analysis. Comparative genomics reveals putative-virulence genes related to bile resistance, chemotaxis, hemolysis, and motility. We detected the existence of hlyA, hlyD, and hlyIII involved in hemolysis. We also found chemotaxis gene cluster cheYZA operon and cheW gene. The results provide insights into the genetic basis underlying pathogenicity in S. algae. |
| format | Article |
| id | doaj-art-26687fe521414d73b90ca9d1cb449d5b |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-26687fe521414d73b90ca9d1cb449d5b2025-02-03T01:21:34ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932020-01-01202010.1155/2020/92051979205197Comparative Genomics Reveals Pathogenicity-Related Loci in Shewanella algaeJui-Hsing Wang0Guo-Cheng He1Yao-Ting Huang2Po-Yu Liu3Division of Infectious Disease, Department of Internal Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427, TaiwanDepartment of Computer Science and Information Engineering, National Chung Cheng University, Chia-Yi 62102, TaiwanDepartment of Internal Medicine, School of Medicine, Tzu Chi University, Hualien 970, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, TaiwanShewanella algae is an emerging marine zoonotic pathogen and accounts for considerable mortality and morbidity in compromised hosts. However, there is scarce literature related to the understanding of the genetic background of virulence determinants in S. algae. In this study, we aim to determine the occurrence of common virulence genes in S. algae using whole-genome sequence and comparative genomic analysis. Comparative genomics reveals putative-virulence genes related to bile resistance, chemotaxis, hemolysis, and motility. We detected the existence of hlyA, hlyD, and hlyIII involved in hemolysis. We also found chemotaxis gene cluster cheYZA operon and cheW gene. The results provide insights into the genetic basis underlying pathogenicity in S. algae.http://dx.doi.org/10.1155/2020/9205197 |
| spellingShingle | Jui-Hsing Wang Guo-Cheng He Yao-Ting Huang Po-Yu Liu Comparative Genomics Reveals Pathogenicity-Related Loci in Shewanella algae Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Comparative Genomics Reveals Pathogenicity-Related Loci in Shewanella algae |
| title_full | Comparative Genomics Reveals Pathogenicity-Related Loci in Shewanella algae |
| title_fullStr | Comparative Genomics Reveals Pathogenicity-Related Loci in Shewanella algae |
| title_full_unstemmed | Comparative Genomics Reveals Pathogenicity-Related Loci in Shewanella algae |
| title_short | Comparative Genomics Reveals Pathogenicity-Related Loci in Shewanella algae |
| title_sort | comparative genomics reveals pathogenicity related loci in shewanella algae |
| url | http://dx.doi.org/10.1155/2020/9205197 |
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