Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD
Abstract Objectives The current study aimed to investigate the structural and functional connectivity of the subregions of the amygdala in children with Attention Deficit/Hyperactivity Disorder (ADHD) only or comorbid with Oppositional Defiant Disorder (ODD). Methods A total of 354 children with ADH...
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2025-01-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-025-06500-4 |
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| author | Zhao-Min Wu Peng Wang Xue-Chun Liu Qing-Chao Zhou Xiao-Lan Cao Li Sun Lu Liu Qing-Jiu Cao Li Yang Yu-Feng Wang Ying Qian Bin-Rang Yang |
| author_facet | Zhao-Min Wu Peng Wang Xue-Chun Liu Qing-Chao Zhou Xiao-Lan Cao Li Sun Lu Liu Qing-Jiu Cao Li Yang Yu-Feng Wang Ying Qian Bin-Rang Yang |
| author_sort | Zhao-Min Wu |
| collection | DOAJ |
| description | Abstract Objectives The current study aimed to investigate the structural and functional connectivity of the subregions of the amygdala in children with Attention Deficit/Hyperactivity Disorder (ADHD) only or comorbid with Oppositional Defiant Disorder (ODD). Methods A total of 354 children with ADHD-only, 161 children with ADHD and ODD (ADHD + ODD), and 100 healthy controls were enrolled. The Child Behavior Checklist (CBCL) and the Behavior Rating Inventory of Executive Function (BRIEF) were filled out by caregivers. Analysis of covariance (ANCOVA) was performed to test group-wise differences in these behavioral measures. A subsample comprising 209 participants underwent a resting-state functional MRI scan and a diffusion-weighted imaging (DWI) scan. Functional connectivity and structural connectivity were calculated using bilateral subregions of the Amygdala as seeds. Between-group voxel-wise comparisons were conducted. Results The ADHD + ODD group had more anxious/depressed moods, more delinquent and aggressive behaviors, more emotional control problems, and more inhibition deficits than the ADHD-only group (all P Bonferroni−corrected < 0.05). Compared with the control and ADHD + ODD groups, the ADHD-only group displayed increased FC strength between the amygdala subregions and the left caudate, left putamen, and frontal cortex. Regarding structural connectivity (SC), the ADHD-only group demonstrated higher streamline density in the left internal capsule, corpus callosum, and the right superior corona radiata. The altered SC was associated with emotional problems in children with ADHD, while the altered FC was associated with other ADHD-related clinical features. Conclusions Altered structural and functional connectivity of the subregions of the amygdala in children with ADHD compared with their healthy counterparts were respectively associated with ADHD-related behavioral and emotional problems. Clinical trial number : not applicable. |
| format | Article |
| id | doaj-art-2660fe75c3464d8d98c4f193c939f9ad |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-2660fe75c3464d8d98c4f193c939f9ad2025-01-26T12:46:38ZengBMCBMC Psychiatry1471-244X2025-01-0125111010.1186/s12888-025-06500-4Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODDZhao-Min Wu0Peng Wang1Xue-Chun Liu2Qing-Chao Zhou3Xiao-Lan Cao4Li Sun5Lu Liu6Qing-Jiu Cao7Li Yang8Yu-Feng Wang9Ying Qian10Bin-Rang Yang11Shenzhen Children’s HospitalCardiac Rehabilitation Center, Fuwai Hospital, CAMS & PUMCShenzhen Children’s HospitalShenzhen Children’s HospitalShenzhen Children’s HospitalInstitute of Mental Health, Peking University Sixth Hospital, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Institute of Mental Health, Peking University Sixth Hospital, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Institute of Mental Health, Peking University Sixth Hospital, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Institute of Mental Health, Peking University Sixth Hospital, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Institute of Mental Health, Peking University Sixth Hospital, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Institute of Mental Health, Peking University Sixth Hospital, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Shenzhen Children’s HospitalAbstract Objectives The current study aimed to investigate the structural and functional connectivity of the subregions of the amygdala in children with Attention Deficit/Hyperactivity Disorder (ADHD) only or comorbid with Oppositional Defiant Disorder (ODD). Methods A total of 354 children with ADHD-only, 161 children with ADHD and ODD (ADHD + ODD), and 100 healthy controls were enrolled. The Child Behavior Checklist (CBCL) and the Behavior Rating Inventory of Executive Function (BRIEF) were filled out by caregivers. Analysis of covariance (ANCOVA) was performed to test group-wise differences in these behavioral measures. A subsample comprising 209 participants underwent a resting-state functional MRI scan and a diffusion-weighted imaging (DWI) scan. Functional connectivity and structural connectivity were calculated using bilateral subregions of the Amygdala as seeds. Between-group voxel-wise comparisons were conducted. Results The ADHD + ODD group had more anxious/depressed moods, more delinquent and aggressive behaviors, more emotional control problems, and more inhibition deficits than the ADHD-only group (all P Bonferroni−corrected < 0.05). Compared with the control and ADHD + ODD groups, the ADHD-only group displayed increased FC strength between the amygdala subregions and the left caudate, left putamen, and frontal cortex. Regarding structural connectivity (SC), the ADHD-only group demonstrated higher streamline density in the left internal capsule, corpus callosum, and the right superior corona radiata. The altered SC was associated with emotional problems in children with ADHD, while the altered FC was associated with other ADHD-related clinical features. Conclusions Altered structural and functional connectivity of the subregions of the amygdala in children with ADHD compared with their healthy counterparts were respectively associated with ADHD-related behavioral and emotional problems. Clinical trial number : not applicable.https://doi.org/10.1186/s12888-025-06500-4ADHDODDAmygdalaFunctional connectivityStructural connectivity |
| spellingShingle | Zhao-Min Wu Peng Wang Xue-Chun Liu Qing-Chao Zhou Xiao-Lan Cao Li Sun Lu Liu Qing-Jiu Cao Li Yang Yu-Feng Wang Ying Qian Bin-Rang Yang Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD BMC Psychiatry ADHD ODD Amygdala Functional connectivity Structural connectivity |
| title | Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD |
| title_full | Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD |
| title_fullStr | Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD |
| title_full_unstemmed | Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD |
| title_short | Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD |
| title_sort | functional and structural connectivity of the subregions of the amygdala in adhd children with or without odd |
| topic | ADHD ODD Amygdala Functional connectivity Structural connectivity |
| url | https://doi.org/10.1186/s12888-025-06500-4 |
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