Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review
One class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products. Peptides are novel active ingredients that improve collagen synthesis, enhance skin cell p...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/1/88 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588890942210048 |
|---|---|
| author | Andrada Pintea Andrei Manea Cezara Pintea Robert-Alexandru Vlad Magdalena Bîrsan Paula Antonoaea Emöke Margit Rédai Adriana Ciurba |
| author_facet | Andrada Pintea Andrei Manea Cezara Pintea Robert-Alexandru Vlad Magdalena Bîrsan Paula Antonoaea Emöke Margit Rédai Adriana Ciurba |
| author_sort | Andrada Pintea |
| collection | DOAJ |
| description | One class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products. Peptides are novel active ingredients that improve collagen synthesis, enhance skin cell proliferation, or decrease inflammation. Based on their mechanism of action, they can be classified into signal peptides, carrier peptides, neurotransmitter inhibitor peptides, and enzyme inhibitor peptides. This review focuses on the main types of peptides and their application in the cosmetic field, underlining their main limitations. One of the most significant drawbacks of cosmetic peptides is their poor permeability through membranes, which limits their delivery and effectiveness. As a result, this review follows the methods used for improving permeability through the stratum corneum. Increasing peptide bioavailability and stability for enhanced delivery to the desired site of action and visible effects have become central points for the latest research due to their promising features. For this purpose, several methods have been identified and described. Physical techniques include thermal ablation (radiofrequency and laser), electrical methods (electroporation, iontophoresis), mechanical approach (microneedles), and ultrasounds. As an alternative, innovative formulations have been developed in nano-systems such as liposomes, niosomes, ethosomes, nanoemulsions, and other nanomaterials to reduce skin irritation and improve product effectiveness. The purpose of this review is to provide the latest information regarding these noteworthy molecules and the reasoning behind their use in cosmetic formulations. |
| format | Article |
| id | doaj-art-26587de23ee74b4e8393afc808d7ae89 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-26587de23ee74b4e8393afc808d7ae892025-01-24T13:25:08ZengMDPI AGBiomolecules2218-273X2025-01-011518810.3390/biom15010088Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A ReviewAndrada Pintea0Andrei Manea1Cezara Pintea2Robert-Alexandru Vlad3Magdalena Bîrsan4Paula Antonoaea5Emöke Margit Rédai6Adriana Ciurba7Medicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaMedicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaMedicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, RomaniaPharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, RomaniaDepartment of Drug Industry and Pharmaceutical Biotechnology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, RomaniaPharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, RomaniaPharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, RomaniaOne class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products. Peptides are novel active ingredients that improve collagen synthesis, enhance skin cell proliferation, or decrease inflammation. Based on their mechanism of action, they can be classified into signal peptides, carrier peptides, neurotransmitter inhibitor peptides, and enzyme inhibitor peptides. This review focuses on the main types of peptides and their application in the cosmetic field, underlining their main limitations. One of the most significant drawbacks of cosmetic peptides is their poor permeability through membranes, which limits their delivery and effectiveness. As a result, this review follows the methods used for improving permeability through the stratum corneum. Increasing peptide bioavailability and stability for enhanced delivery to the desired site of action and visible effects have become central points for the latest research due to their promising features. For this purpose, several methods have been identified and described. Physical techniques include thermal ablation (radiofrequency and laser), electrical methods (electroporation, iontophoresis), mechanical approach (microneedles), and ultrasounds. As an alternative, innovative formulations have been developed in nano-systems such as liposomes, niosomes, ethosomes, nanoemulsions, and other nanomaterials to reduce skin irritation and improve product effectiveness. The purpose of this review is to provide the latest information regarding these noteworthy molecules and the reasoning behind their use in cosmetic formulations.https://www.mdpi.com/2218-273X/15/1/88cosmetic peptidesanti-aging productspermeabilitynano-systems |
| spellingShingle | Andrada Pintea Andrei Manea Cezara Pintea Robert-Alexandru Vlad Magdalena Bîrsan Paula Antonoaea Emöke Margit Rédai Adriana Ciurba Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review Biomolecules cosmetic peptides anti-aging products permeability nano-systems |
| title | Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review |
| title_full | Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review |
| title_fullStr | Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review |
| title_full_unstemmed | Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review |
| title_short | Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review |
| title_sort | peptides emerging candidates for the prevention and treatment of skin senescence a review |
| topic | cosmetic peptides anti-aging products permeability nano-systems |
| url | https://www.mdpi.com/2218-273X/15/1/88 |
| work_keys_str_mv | AT andradapintea peptidesemergingcandidatesforthepreventionandtreatmentofskinsenescenceareview AT andreimanea peptidesemergingcandidatesforthepreventionandtreatmentofskinsenescenceareview AT cezarapintea peptidesemergingcandidatesforthepreventionandtreatmentofskinsenescenceareview AT robertalexandruvlad peptidesemergingcandidatesforthepreventionandtreatmentofskinsenescenceareview AT magdalenabirsan peptidesemergingcandidatesforthepreventionandtreatmentofskinsenescenceareview AT paulaantonoaea peptidesemergingcandidatesforthepreventionandtreatmentofskinsenescenceareview AT emokemargitredai peptidesemergingcandidatesforthepreventionandtreatmentofskinsenescenceareview AT adrianaciurba peptidesemergingcandidatesforthepreventionandtreatmentofskinsenescenceareview |